Aerosolized Recombinant Human Deoxyribonuclease I in the Treatment of Cystic Fibrosis

Bruce K. Rubin, Richard C. Hubbard, Steven Shak, Ronald Crystal

Research output: Contribution to journalLetter

7 Citations (Scopus)


To the Editor: The preliminary report by Hubbard et al. (March 19 issue)1 on the use of aerosolized recombinant human deoxyribonuclease I (rhDNase) in the treatment of cystic fibrosis is intriguing, but the authors appear to have concluded that rhDNase reduced sputum viscoelasticity in vivo without support from the data. It has been demonstrated that sputum from patients with cystic fibrosis is equally or less viscoelastic than sputum from patients with chronic bronchitis or dogs that have undergone tracheostomy.2 3 4 5 A reference cited by the authors to support the contention that sputum in cystic fibrosis is hyperviscous because of its DNA…

Original languageEnglish
Number of pages1
JournalNew England Journal of Medicine
Issue number8
Publication statusPublished - 20 Aug 1992
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

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