Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood

Daisuke Chujo, Thien Son Nguyen, Emile Foucat, Derek Blankenship, Jacques Banchereau, Gerald T. Nepom, Damien J. Chaussabel, Hideki Ueno

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The breakdown of immune tolerance against islet antigens causes type 1 diabetes (T1D). The antigens associated with adult-onset T1D (AT1D) remain largely undefined. It is possible that AT1D patients display a unique type of CD4+ T cells specific for a certain islet antigen. Here we analyzed the cytokine production profiles of CD4+ helper T (Th) cells that are specific for three islet antigens; GAD65, preproinsulin, and IGRP in patients with AT1D, juvenile-onset T1D (JT1D), and age-, gender- and human leukocyte antigen (HLA)-matched control adults. While IGRP-specific Th cells in AT1D patients were dominantly Th1 cells, IGRP-specific Th cells in control adults and JT1D patients were dominantly Th2 and T regulatory type 1 (Tr1) cells. Notably, the frequency of IGRP-specific Tr1 cells was significantly lower in AT1D patients than in control adults and JT1D patients. In conclusion, our study suggests that IGRP-specific Th cells play a unique pathogenic role in AT1D.

Original languageEnglish
Pages (from-to)270-277
Number of pages8
JournalClinical Immunology
Volume161
Issue number2
DOIs
Publication statusPublished - 1 Dec 2015
Externally publishedYes

Fingerprint

Regulatory T-Lymphocytes
Type 1 Diabetes Mellitus
Antigens
Immune Tolerance
Th1 Cells
HLA Antigens
Helper-Inducer T-Lymphocytes
Cytokines
T-Lymphocytes

Keywords

  • CD4 T cells
  • Islet antigens
  • Islet-specific glucose 6 phosphatase catalytic subunit-related protein
  • T regulatory type 1 (Tr1) cells
  • Type 1 diabetes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Chujo, D., Nguyen, T. S., Foucat, E., Blankenship, D., Banchereau, J., Nepom, G. T., ... Ueno, H. (2015). Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood. Clinical Immunology, 161(2), 270-277. https://doi.org/10.1016/j.clim.2015.08.014

Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood. / Chujo, Daisuke; Nguyen, Thien Son; Foucat, Emile; Blankenship, Derek; Banchereau, Jacques; Nepom, Gerald T.; Chaussabel, Damien J.; Ueno, Hideki.

In: Clinical Immunology, Vol. 161, No. 2, 01.12.2015, p. 270-277.

Research output: Contribution to journalArticle

Chujo, D, Nguyen, TS, Foucat, E, Blankenship, D, Banchereau, J, Nepom, GT, Chaussabel, DJ & Ueno, H 2015, 'Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood', Clinical Immunology, vol. 161, no. 2, pp. 270-277. https://doi.org/10.1016/j.clim.2015.08.014
Chujo D, Nguyen TS, Foucat E, Blankenship D, Banchereau J, Nepom GT et al. Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood. Clinical Immunology. 2015 Dec 1;161(2):270-277. https://doi.org/10.1016/j.clim.2015.08.014
Chujo, Daisuke ; Nguyen, Thien Son ; Foucat, Emile ; Blankenship, Derek ; Banchereau, Jacques ; Nepom, Gerald T. ; Chaussabel, Damien J. ; Ueno, Hideki. / Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood. In: Clinical Immunology. 2015 ; Vol. 161, No. 2. pp. 270-277.
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