Adult lung function and long-term air pollution exposure. ESCAPE: A multicentre cohort study and meta-analysis

Martin Adam; Tamara Schikowski; Anne Elie Carsin; Yutong Cai; Benedicte Jacquemin; Margaux Sanchez; Andrea Vierkötter; Alessandro Marcon; Dirk Keidel; Dorothee Sugiri; Zeinab Al Kanaani; Rachel Nadif; Valérie Siroux; Rebecca Hardy; Diana Kuh; Thierry Rochat; Pierre Olivier Bridevaux; Marloes Eeftens; Ming Yi Tsai; Simona Villani; Harish Chandra Phuleria; Matthias Birk; Josef Cyrys; Marta Cirach; Audrey De Nazelle; Mark J. Nieuwenhuijsen; Bertil Forsberg; Kees De Hoogh; Christophe Declerq; Roberto Bono; Pavilio Piccioni; Ulrich Quass; Joachim Heinrich; Deborah Jarvis; Isabelle Pin; Rob Beelen; Gerard Hoek; Bert Brunekreef; Christian Schindler; Jordi Sunyer; Ursula Krämer; Francine Kauffmann; Anna L. Hansell; Nino Künzli; Nicole Probst-Hensch

doi:10.1183/09031936.00130014

Adult lung function and long-term air pollution exposure. ESCAPE: A multicentre cohort study and meta-analysis

Martin Adam, Tamara Schikowski, Anne Elie Carsin, Yutong Cai, Benedicte Jacquemin, Margaux Sanchez, Andrea Vierkötter, Alessandro Marcon, Dirk Keidel, Dorothee Sugiri, Zeinab Al Kanaani, Rachel Nadif, Valérie Siroux, Rebecca Hardy, Diana Kuh, Thierry Rochat, Pierre Olivier Bridevaux, Marloes Eeftens, Ming Yi Tsai, Simona VillaniHarish Chandra Phuleria, Matthias Birk, Josef Cyrys, Marta Cirach, Audrey De Nazelle, Mark J. Nieuwenhuijsen, Bertil Forsberg, Kees De Hoogh, Christophe Declerq, Roberto Bono, Pavilio Piccioni, Ulrich Quass, Joachim Heinrich, Deborah Jarvis, Isabelle Pin, Rob Beelen, Gerard Hoek, Bert Brunekreef, Christian Schindler, Jordi Sunyer, Ursula Krämer, Francine Kauffmann, Anna L. Hansell, Nino Künzli, Nicole Probst-Hensch

Research output: Contribution to journal › Article

132 Citations (Scopus)

Abstract

The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO₂, NO_x) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10μg·m^-3 increase in NO₂ exposure was associated with lower levels of FEV₁ (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m^-3 in PM₁₀, but not other PM metrics (PM_2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV₁ (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI-112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.

Original language	English
Pages (from-to)	38-50
Number of pages	13
Journal	European Respiratory Journal
Volume	45
Issue number	1
DOIs	https://doi.org/10.1183/09031936.00130014
Publication status	Published - 1 Jan 2015
Externally published	Yes

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ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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Adam, M., Schikowski, T., Carsin, A. E., Cai, Y., Jacquemin, B., Sanchez, M., Vierkötter, A., Marcon, A., Keidel, D., Sugiri, D., Al Kanaani, Z., Nadif, R., Siroux, V., Hardy, R., Kuh, D., Rochat, T., Bridevaux, P. O., Eeftens, M., Tsai, M. Y., ... Probst-Hensch, N. (2015). Adult lung function and long-term air pollution exposure. ESCAPE: A multicentre cohort study and meta-analysis. European Respiratory Journal, 45(1), 38-50. https://doi.org/10.1183/09031936.00130014

Adult lung function and long-term air pollution exposure. ESCAPE : A multicentre cohort study and meta-analysis. / Adam, Martin; Schikowski, Tamara; Carsin, Anne Elie; Cai, Yutong; Jacquemin, Benedicte; Sanchez, Margaux; Vierkötter, Andrea; Marcon, Alessandro; Keidel, Dirk; Sugiri, Dorothee; Al Kanaani, Zeinab; Nadif, Rachel; Siroux, Valérie; Hardy, Rebecca; Kuh, Diana; Rochat, Thierry; Bridevaux, Pierre Olivier; Eeftens, Marloes; Tsai, Ming Yi; Villani, Simona; Phuleria, Harish Chandra; Birk, Matthias; Cyrys, Josef; Cirach, Marta; De Nazelle, Audrey; Nieuwenhuijsen, Mark J.; Forsberg, Bertil; De Hoogh, Kees; Declerq, Christophe; Bono, Roberto; Piccioni, Pavilio; Quass, Ulrich; Heinrich, Joachim; Jarvis, Deborah; Pin, Isabelle; Beelen, Rob; Hoek, Gerard; Brunekreef, Bert; Schindler, Christian; Sunyer, Jordi; Krämer, Ursula; Kauffmann, Francine; Hansell, Anna L.; Künzli, Nino; Probst-Hensch, Nicole.

In: European Respiratory Journal, Vol. 45, No. 1, 01.01.2015, p. 38-50.

Research output: Contribution to journal › Article

Adam, M, Schikowski, T, Carsin, AE, Cai, Y, Jacquemin, B, Sanchez, M, Vierkötter, A, Marcon, A, Keidel, D, Sugiri, D, Al Kanaani, Z, Nadif, R, Siroux, V, Hardy, R, Kuh, D, Rochat, T, Bridevaux, PO, Eeftens, M, Tsai, MY, Villani, S, Phuleria, HC, Birk, M, Cyrys, J, Cirach, M, De Nazelle, A, Nieuwenhuijsen, MJ, Forsberg, B, De Hoogh, K, Declerq, C, Bono, R, Piccioni, P, Quass, U, Heinrich, J, Jarvis, D, Pin, I, Beelen, R, Hoek, G, Brunekreef, B, Schindler, C, Sunyer, J, Krämer, U, Kauffmann, F, Hansell, AL, Künzli, N & Probst-Hensch, N 2015, 'Adult lung function and long-term air pollution exposure. ESCAPE: A multicentre cohort study and meta-analysis', European Respiratory Journal, vol. 45, no. 1, pp. 38-50. https://doi.org/10.1183/09031936.00130014

Adam, Martin ; Schikowski, Tamara ; Carsin, Anne Elie ; Cai, Yutong ; Jacquemin, Benedicte ; Sanchez, Margaux ; Vierkötter, Andrea ; Marcon, Alessandro ; Keidel, Dirk ; Sugiri, Dorothee ; Al Kanaani, Zeinab ; Nadif, Rachel ; Siroux, Valérie ; Hardy, Rebecca ; Kuh, Diana ; Rochat, Thierry ; Bridevaux, Pierre Olivier ; Eeftens, Marloes ; Tsai, Ming Yi ; Villani, Simona ; Phuleria, Harish Chandra ; Birk, Matthias ; Cyrys, Josef ; Cirach, Marta ; De Nazelle, Audrey ; Nieuwenhuijsen, Mark J. ; Forsberg, Bertil ; De Hoogh, Kees ; Declerq, Christophe ; Bono, Roberto ; Piccioni, Pavilio ; Quass, Ulrich ; Heinrich, Joachim ; Jarvis, Deborah ; Pin, Isabelle ; Beelen, Rob ; Hoek, Gerard ; Brunekreef, Bert ; Schindler, Christian ; Sunyer, Jordi ; Krämer, Ursula ; Kauffmann, Francine ; Hansell, Anna L. ; Künzli, Nino ; Probst-Hensch, Nicole. / Adult lung function and long-term air pollution exposure. ESCAPE : A multicentre cohort study and meta-analysis. In: European Respiratory Journal. 2015 ; Vol. 45, No. 1. pp. 38-50.

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10.1183/09031936.00130014