Abstract
The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10μg·m-3 increase in NO2 exposure was associated with lower levels of FEV1 (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m-3 in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI-112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
| Original language | English |
|---|---|
| Pages (from-to) | 38-50 |
| Number of pages | 13 |
| Journal | European Respiratory Journal |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2015 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Adult lung function and long-term air pollution exposure. ESCAPE : A multicentre cohort study and meta-analysis. / Adam, Martin; Schikowski, Tamara; Carsin, Anne Elie; Cai, Yutong; Jacquemin, Benedicte; Sanchez, Margaux; Vierkötter, Andrea; Marcon, Alessandro; Keidel, Dirk; Sugiri, Dorothee; Al Kanaani, Zeinab; Nadif, Rachel; Siroux, Valérie; Hardy, Rebecca; Kuh, Diana; Rochat, Thierry; Bridevaux, Pierre Olivier; Eeftens, Marloes; Tsai, Ming Yi; Villani, Simona; Phuleria, Harish Chandra; Birk, Matthias; Cyrys, Josef; Cirach, Marta; De Nazelle, Audrey; Nieuwenhuijsen, Mark J.; Forsberg, Bertil; De Hoogh, Kees; Declerq, Christophe; Bono, Roberto; Piccioni, Pavilio; Quass, Ulrich; Heinrich, Joachim; Jarvis, Deborah; Pin, Isabelle; Beelen, Rob; Hoek, Gerard; Brunekreef, Bert; Schindler, Christian; Sunyer, Jordi; Krämer, Ursula; Kauffmann, Francine; Hansell, Anna L.; Künzli, Nino; Probst-Hensch, Nicole.
In: European Respiratory Journal, Vol. 45, No. 1, 01.01.2015, p. 38-50.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adult lung function and long-term air pollution exposure. ESCAPE
T2 - A multicentre cohort study and meta-analysis
AU - Adam, Martin
AU - Schikowski, Tamara
AU - Carsin, Anne Elie
AU - Cai, Yutong
AU - Jacquemin, Benedicte
AU - Sanchez, Margaux
AU - Vierkötter, Andrea
AU - Marcon, Alessandro
AU - Keidel, Dirk
AU - Sugiri, Dorothee
AU - Al Kanaani, Zeinab
AU - Nadif, Rachel
AU - Siroux, Valérie
AU - Hardy, Rebecca
AU - Kuh, Diana
AU - Rochat, Thierry
AU - Bridevaux, Pierre Olivier
AU - Eeftens, Marloes
AU - Tsai, Ming Yi
AU - Villani, Simona
AU - Phuleria, Harish Chandra
AU - Birk, Matthias
AU - Cyrys, Josef
AU - Cirach, Marta
AU - De Nazelle, Audrey
AU - Nieuwenhuijsen, Mark J.
AU - Forsberg, Bertil
AU - De Hoogh, Kees
AU - Declerq, Christophe
AU - Bono, Roberto
AU - Piccioni, Pavilio
AU - Quass, Ulrich
AU - Heinrich, Joachim
AU - Jarvis, Deborah
AU - Pin, Isabelle
AU - Beelen, Rob
AU - Hoek, Gerard
AU - Brunekreef, Bert
AU - Schindler, Christian
AU - Sunyer, Jordi
AU - Krämer, Ursula
AU - Kauffmann, Francine
AU - Hansell, Anna L.
AU - Künzli, Nino
AU - Probst-Hensch, Nicole
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10μg·m-3 increase in NO2 exposure was associated with lower levels of FEV1 (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m-3 in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI-112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
AB - The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10μg·m-3 increase in NO2 exposure was associated with lower levels of FEV1 (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m-3 in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI-112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
UR - http://www.scopus.com/inward/record.url?scp=84920612590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920612590&partnerID=8YFLogxK
U2 - 10.1183/09031936.00130014
DO - 10.1183/09031936.00130014
M3 - Article
VL - 45
SP - 38
EP - 50
JO - Acta tuberculosea Scandinavica
JF - Acta tuberculosea Scandinavica
SN - 0903-1936
IS - 1
ER -