Adipokines in neurovascular diseases

Radka Opatrilova, Martin Caprnda, Peter Kubatka, Vanda Valentova, Sona Uramova, Vladimir Nosal, Ludovit Gaspar, Lukas Zachar, Ioana Mozos, Daniel Petrovic, Jozef Dragasek, Slavomira Filipova, Dietrich Busselberg, Anthony Zulli, Luis Rodrigo, Peter Kruzliak, Vladimir Krasnik

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.

Original languageEnglish
Pages (from-to)424-432
Number of pages9
JournalBiomedicine and Pharmacotherapy
Volume98
DOIs
Publication statusPublished - 1 Feb 2018

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Keywords

  • Adipokines
  • Adiponectin
  • Apelin
  • Atherosclerosis
  • Inflammation
  • Ischemic stroke
  • Leptin
  • Metabolic changes
  • Resistin
  • Visfatin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Opatrilova, R., Caprnda, M., Kubatka, P., Valentova, V., Uramova, S., Nosal, V., Gaspar, L., Zachar, L., Mozos, I., Petrovic, D., Dragasek, J., Filipova, S., Busselberg, D., Zulli, A., Rodrigo, L., Kruzliak, P., & Krasnik, V. (2018). Adipokines in neurovascular diseases. Biomedicine and Pharmacotherapy, 98, 424-432. https://doi.org/10.1016/j.biopha.2017.12.074