Addressing missing nodes as missing data in dynamic causal modeling

Christopher L. Wyatt, Shaza Zaghlool

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dynamic Causal Modeling (DCM) uses dynamical systems to represent the high-level neural processing strategy for a given cognitive task. The logical network topology of the model is specified by a combination of prior knowledge and statistical analysis of the neuro-imaging signals. Parameters of this a-priori model are then estimated and competing models are compared to determine the most likely model given experimental data. Inter-subject analysis using DCM requires considerable judgement on the part of the experimenter to decide on the validity of assumptions used in the modeling and statistical analysis; in particular, the dropping of subjects with insufficient activity in a region of the model and ignoring activations not included in the model. This manual data filtering is required so that the model's network size is consistent across subjects. A solution to this problem would ease using DCM in population studies and reduce potential sources of experimental bias. The paper describes and compares three different approaches to allow inter-subject comparisons by treating variation in the network size as a missing data problem. These approaches are compared with respect to accuracy in classifying and predicting subject DCMs using simulated data.

Original languageEnglish
Title of host publicationProceedings - 2012 2nd International Workshop on Pattern Recognition in NeuroImaging, PRNI 2012
Pages81-84
Number of pages4
DOIs
Publication statusPublished - 29 Oct 2012
Externally publishedYes
Event2012 2nd International Workshop on Pattern Recognition in NeuroImaging, PRNI 2012 - London, United Kingdom
Duration: 2 Jul 20124 Jul 2012

Other

Other2012 2nd International Workshop on Pattern Recognition in NeuroImaging, PRNI 2012
CountryUnited Kingdom
CityLondon
Period2/7/124/7/12

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Keywords

  • Dymanic Causal Modeling
  • Graph Topology
  • Missing Data

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Electrical and Electronic Engineering

Cite this

Wyatt, C. L., & Zaghlool, S. (2012). Addressing missing nodes as missing data in dynamic causal modeling. In Proceedings - 2012 2nd International Workshop on Pattern Recognition in NeuroImaging, PRNI 2012 (pp. 81-84). [6295933] https://doi.org/10.1109/PRNI.2012.29