Active, specific immunotherapy for lung cancer: Hurdles and strategies using genetic modification

Robert J. Korst, Ronald Crystal

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Active immunotherapy for lung cancer has been a challenge because of the poor antigenic characterization of these tumors and their ability to escape the immune response. However, knowledge of the mechanisms of anti-tumor immunity has expanded significantly over the past decade, leading to the development of more novel, specific strategies for augmenting the immune response. Genetic manipulation of tumor cells, immune cells, or both, may help overcome some of the previously encountered difficulties of immunotherapy. Laboratory and clinical investigations are currently ongoing to evaluate the feasibility and potential benefit of these novel approaches.

Original languageEnglish
Pages (from-to)1319-1326
Number of pages8
JournalAnnals of Thoracic Surgery
Volume76
Issue number4
DOIs
Publication statusPublished - 1 Oct 2003
Externally publishedYes

Fingerprint

Active Immunotherapy
Lung Neoplasms
Neoplasms
Immunotherapy
Immunity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Active, specific immunotherapy for lung cancer : Hurdles and strategies using genetic modification. / Korst, Robert J.; Crystal, Ronald.

In: Annals of Thoracic Surgery, Vol. 76, No. 4, 01.10.2003, p. 1319-1326.

Research output: Contribution to journalReview article

@article{9b769e407d8e4663aac0a05c1161785b,
title = "Active, specific immunotherapy for lung cancer: Hurdles and strategies using genetic modification",
abstract = "Active immunotherapy for lung cancer has been a challenge because of the poor antigenic characterization of these tumors and their ability to escape the immune response. However, knowledge of the mechanisms of anti-tumor immunity has expanded significantly over the past decade, leading to the development of more novel, specific strategies for augmenting the immune response. Genetic manipulation of tumor cells, immune cells, or both, may help overcome some of the previously encountered difficulties of immunotherapy. Laboratory and clinical investigations are currently ongoing to evaluate the feasibility and potential benefit of these novel approaches.",
author = "Korst, {Robert J.} and Ronald Crystal",
year = "2003",
month = "10",
day = "1",
doi = "10.1016/S0003-4975(03)00651-9",
language = "English",
volume = "76",
pages = "1319--1326",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Active, specific immunotherapy for lung cancer

T2 - Hurdles and strategies using genetic modification

AU - Korst, Robert J.

AU - Crystal, Ronald

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Active immunotherapy for lung cancer has been a challenge because of the poor antigenic characterization of these tumors and their ability to escape the immune response. However, knowledge of the mechanisms of anti-tumor immunity has expanded significantly over the past decade, leading to the development of more novel, specific strategies for augmenting the immune response. Genetic manipulation of tumor cells, immune cells, or both, may help overcome some of the previously encountered difficulties of immunotherapy. Laboratory and clinical investigations are currently ongoing to evaluate the feasibility and potential benefit of these novel approaches.

AB - Active immunotherapy for lung cancer has been a challenge because of the poor antigenic characterization of these tumors and their ability to escape the immune response. However, knowledge of the mechanisms of anti-tumor immunity has expanded significantly over the past decade, leading to the development of more novel, specific strategies for augmenting the immune response. Genetic manipulation of tumor cells, immune cells, or both, may help overcome some of the previously encountered difficulties of immunotherapy. Laboratory and clinical investigations are currently ongoing to evaluate the feasibility and potential benefit of these novel approaches.

UR - http://www.scopus.com/inward/record.url?scp=0141673669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141673669&partnerID=8YFLogxK

U2 - 10.1016/S0003-4975(03)00651-9

DO - 10.1016/S0003-4975(03)00651-9

M3 - Review article

C2 - 14530047

AN - SCOPUS:0141673669

VL - 76

SP - 1319

EP - 1326

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 4

ER -