Active, specific immunotherapy for lung cancer: Hurdles and strategies using genetic modification

Robert J. Korst, Ronald Crystal

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Active immunotherapy for lung cancer has been a challenge because of the poor antigenic characterization of these tumors and their ability to escape the immune response. However, knowledge of the mechanisms of anti-tumor immunity has expanded significantly over the past decade, leading to the development of more novel, specific strategies for augmenting the immune response. Genetic manipulation of tumor cells, immune cells, or both, may help overcome some of the previously encountered difficulties of immunotherapy. Laboratory and clinical investigations are currently ongoing to evaluate the feasibility and potential benefit of these novel approaches.

Original languageEnglish
Pages (from-to)1319-1326
Number of pages8
JournalAnnals of Thoracic Surgery
Volume76
Issue number4
DOIs
Publication statusPublished - 1 Oct 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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