Accelerated graft loss

Association with presensitization to donor B-cell (Ia) antigens

Manikkam Suthanthiran, P. Gailiunas, A. Person, G. Fagan, T. B. Strom, C. B. Carpenter, M. R. Garovoy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Humoral presensitization to B-cell (Ia) antigens is associated with a high rate of early allograft failure, while lack of such presensitization is associated with favorable graft outcome. Our findings of adverse influence of presensitization to donor B-cell (Ia) antigens is at variance with the findings of Ettenger et al., who have recently reported stable graft function (serum creatinine <2 mg/100 ml at 1 month) in 9 of 15 recipients with a positive pretransplant B-cell cytotoxicity assay. The recent recognition that monocytes contaminating E-rosette-depleted B-cell-enriched populations and cold reactive cytotoxic antibodies absorbable with platelets and red cells may be responsible for extra reactions in the B-cell cytotoxicity assay introduces the possibility that some of the sera from patients studied by Ettenger et al. may not be recognizing B-cell alloantigens. The possibility that the inhibition of EA rosettes by cytotoxic negative sera may in some cases be due to some other yet unrecognized antigenic system in man cannot be excluded in our study.

Original languageEnglish
Pages (from-to)471-473
Number of pages3
JournalTransplantation Proceedings
Volume10
Issue number2
Publication statusPublished - 1 Dec 1978
Externally publishedYes

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Histocompatibility Antigens Class II
B-Lymphocytes
Tissue Donors
Transplants
Serum
Isoantigens
Allografts
Monocytes
Creatinine
Blood Platelets
Antibodies
Population

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Suthanthiran, M., Gailiunas, P., Person, A., Fagan, G., Strom, T. B., Carpenter, C. B., & Garovoy, M. R. (1978). Accelerated graft loss: Association with presensitization to donor B-cell (Ia) antigens. Transplantation Proceedings, 10(2), 471-473.

Accelerated graft loss : Association with presensitization to donor B-cell (Ia) antigens. / Suthanthiran, Manikkam; Gailiunas, P.; Person, A.; Fagan, G.; Strom, T. B.; Carpenter, C. B.; Garovoy, M. R.

In: Transplantation Proceedings, Vol. 10, No. 2, 01.12.1978, p. 471-473.

Research output: Contribution to journalArticle

Suthanthiran, M, Gailiunas, P, Person, A, Fagan, G, Strom, TB, Carpenter, CB & Garovoy, MR 1978, 'Accelerated graft loss: Association with presensitization to donor B-cell (Ia) antigens', Transplantation Proceedings, vol. 10, no. 2, pp. 471-473.
Suthanthiran M, Gailiunas P, Person A, Fagan G, Strom TB, Carpenter CB et al. Accelerated graft loss: Association with presensitization to donor B-cell (Ia) antigens. Transplantation Proceedings. 1978 Dec 1;10(2):471-473.
Suthanthiran, Manikkam ; Gailiunas, P. ; Person, A. ; Fagan, G. ; Strom, T. B. ; Carpenter, C. B. ; Garovoy, M. R. / Accelerated graft loss : Association with presensitization to donor B-cell (Ia) antigens. In: Transplantation Proceedings. 1978 ; Vol. 10, No. 2. pp. 471-473.
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