Abundant protein domains occur in proportion to proteome size.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND: Conserved domains in proteins have crucial roles in protein interactions, DNA binding, enzyme activity and other important cellular processes. It will be of interest to determine the proportions of genes containing such domains in the proteomes of different eukaryotes. RESULTS: The average proportion of conserved domains in each of five eukaryote genomes was calculated. In pairwise genome comparisons, the ratio of genes containing a given conserved domain in the two genomes on average reflected the ratio of the predicted total gene numbers of the two genomes. These ratios have been verified using a repository of databases and one of its subdivisions of conserved domains. CONCLUSIONS: Many conserved domains occur as a constant proportion of proteome size across the five sequenced eukaryotic genomes. This raises the possibility that this proportion is maintained because of functional constraints on interacting domains. The universality of the ratio in the five eukaryotic genomes attests to its potential importance.

Original languageEnglish
JournalGenome Biology
Volume2
Issue number9
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Proteome
proteome
genome
Genome
protein
proteins
eukaryote
Eukaryota
eukaryotic cells
gene
Genes
genes
DNA-Binding Proteins
repository
enzyme activity
Protein Domains
Databases
DNA
Enzymes

ASJC Scopus subject areas

  • Genetics

Cite this

Abundant protein domains occur in proportion to proteome size. / Malek, Joel.

In: Genome Biology, Vol. 2, No. 9, 2001.

Research output: Contribution to journalArticle

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