Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension

Xavier Jeunemaitre, Richard P. Lifton, Steven Hunt, Roger R. Williams, Jean Marc Lalouel

Research output: Contribution to journalArticle

375 Citations (Scopus)

Abstract

The angiotensin converting enzyme (ACE) is a key component of the renin angiotensin system that contributes to the regulation of blood pressure (BP). Recent demonstration of linkage between the ACE locus and elevated BP in a rat model of hypertension has further emphasized ACE as a candidate gene in human hypertension1,2,3. We report the localization of the ACE gene on the genetic map of chromosome 17, and identify an extremely polymorphic marker at the human growth hormone (hGH) locus which shows no recombination with ACE. We have found no evidence to support linkage between the ACE locus and hypertension, which suggests that mutations at the ACE locus do not commonly contribute to the pathogenesis of hypertension in our test population.

Original languageEnglish
Pages (from-to)72-75
Number of pages4
JournalNature Genetics
Volume1
Issue number1
DOIs
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Peptidyl-Dipeptidase A
Hypertension
Blood Pressure
Chromosomes, Human, Pair 17
Human Growth Hormone
Renin-Angiotensin System
Essential Hypertension
Genetic Recombination
Genes
Mutation
Population

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. / Jeunemaitre, Xavier; Lifton, Richard P.; Hunt, Steven; Williams, Roger R.; Lalouel, Jean Marc.

In: Nature Genetics, Vol. 1, No. 1, 1992, p. 72-75.

Research output: Contribution to journalArticle

Jeunemaitre, Xavier ; Lifton, Richard P. ; Hunt, Steven ; Williams, Roger R. ; Lalouel, Jean Marc. / Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. In: Nature Genetics. 1992 ; Vol. 1, No. 1. pp. 72-75.
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