Abnormal cervical cytology after allogeneic bone marrow transplantation

Giovanni Negri, Martina Herz, Sara Deola, Andrea Piccin, Marco Casini, Bianca Babich, Martina Tauber, Sergio Messini, Maria Raffaella Marucci, Fabio Vittadello

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Allogeneic bone marrow transplantation (BMT) is a procedure mostly used for high-risk hematologic malignances. In women, follow-up protocols after BMT include gynecologic checkups with Papanicolaou (Pap) smears.

Methods: We evaluated 117 Pap smears in 54 women who underwent allogeneic BMT and correlated the smear morphology with the BMT-related medical treatment.

Results: Abnormal Pap smears after BMT were found in 13 (24.1%) women. Four (7.4%) women had at least one smear with atypical squamous cells of unknown significance, six (11.1%) had a low-grade squamous intraepithelial lesion, and three (5.6%) had atypical squamous cells/high-grade lesion cannot be excluded (ASC-H). The three patients with ASC-H showed high-grade atypia mimicking cancer but had a negative follow-up. Nine women, including the three with ASC-H, had undergone a conditioning therapy for BMT that included busulfan. No association between other drugs and therapy-related atypia was found.

Conclusions: Pap smears after BMT show a high incidence of dysplastic lesions. Moreover, conditioning including busulfan is often associated with therapy-related cytologic atypia, which may lead to unnecessary colposcopies and biopsies. Knowledge of the patient's history and a careful evaluation of the smears are mandatory in these cases.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume142
Issue number2
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Fingerprint

Homologous Transplantation
Bone Marrow Transplantation
Cell Biology
Papanicolaou Test
Busulfan
Colposcopy
Behavior Therapy
Biopsy
Drug Therapy
Incidence
Therapeutics
Neoplasms

Keywords

  • Atypia
  • Bone marrow transplantation
  • Busulfan
  • Cervical cytology
  • Pap smear

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Abnormal cervical cytology after allogeneic bone marrow transplantation. / Negri, Giovanni; Herz, Martina; Deola, Sara; Piccin, Andrea; Casini, Marco; Babich, Bianca; Tauber, Martina; Messini, Sergio; Marucci, Maria Raffaella; Vittadello, Fabio.

In: American Journal of Clinical Pathology, Vol. 142, No. 2, 01.01.2014, p. 222-226.

Research output: Contribution to journalArticle

Negri, G, Herz, M, Deola, S, Piccin, A, Casini, M, Babich, B, Tauber, M, Messini, S, Marucci, MR & Vittadello, F 2014, 'Abnormal cervical cytology after allogeneic bone marrow transplantation', American Journal of Clinical Pathology, vol. 142, no. 2, pp. 222-226. https://doi.org/10.1309/AJCP4SKAUS9TOTJX
Negri, Giovanni ; Herz, Martina ; Deola, Sara ; Piccin, Andrea ; Casini, Marco ; Babich, Bianca ; Tauber, Martina ; Messini, Sergio ; Marucci, Maria Raffaella ; Vittadello, Fabio. / Abnormal cervical cytology after allogeneic bone marrow transplantation. In: American Journal of Clinical Pathology. 2014 ; Vol. 142, No. 2. pp. 222-226.
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