Abdominal multivisceral transplantation

Satoru Todo, Andreas Tzakis, Kareem Abu-Elmagd, Jorge Reyes, Hiroyuki Furukawa, Bakr Nour, John Fung, Anthony Demetris, Thomas E. Starzl

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Abstract

Under FK506-based immunosuppression, 13 abdominal multivisceral transplantations were performed in 6 children and 7 adults. Of the 13 recipients, 7 (53.8%) are alive and well with functioning grafts after 9 to 31 months. Six recipients died: Three from PTLD, one from rejection, one from sepsis, and one from respiratory failure. In addition to rejection, postoperative complications occurring in more than isolated cases included PTLD (n=6), abdominal abscess formation (n=5), pancreatitis (n=3), and ampullary dysfunction (n=2). In addition, infection by enteric microorganisms was common during the early postoperative period. Currently, all 7 survivors are on an oral diet and have normal liver function. Two recipients (one insulin-dependent) require antidiabetes treatment, in one case following distal pancreatectomy and in the other after two episodes of pancreatic rejection. Thus, abdominal multivisceral transplantation is a difficult but feasible operation that demands complex and prolonged posttransplantation management. It is not yet ready for application and awaits a better strategy of immune modulation.

Original languageEnglish
Pages (from-to)234-240
Number of pages7
JournalTransplantation
Volume59
Issue number2
Publication statusPublished - 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Todo, S., Tzakis, A., Abu-Elmagd, K., Reyes, J., Furukawa, H., Nour, B., Fung, J., Demetris, A., & Starzl, T. E. (1995). Abdominal multivisceral transplantation. Transplantation, 59(2), 234-240.