A triple helix model for the structure of chromatin fiber

V. Makarov, S. Dimitrov, V. Smirnov, I. Pashev

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A model of chromatin fiber structure is presented in which a repeating unit of a trinucleosome forms a 3-dimensional zigzag. Twisting and compression of the zigzag result in a triple helix structure. The model is built mainly on the flow linear dichroism data showing that (a) nucleosomal disc faces are tilted relative to the fiber axis, (b) the orientation of nucleosomes does not change upon folding and unfolding of chromatin, and (c) the orientation of nucleosomes is maintained by the globular domain of histone HI.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalFEBS Letters
Volume181
Issue number2
DOIs
Publication statusPublished - 25 Feb 1985
Externally publishedYes

Fingerprint

Nucleosomes
Chromatin
Fibers
Histones

Keywords

  • Chromatin structure Flow linear dichroism Nucleosome orientation Histone HI

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

A triple helix model for the structure of chromatin fiber. / Makarov, V.; Dimitrov, S.; Smirnov, V.; Pashev, I.

In: FEBS Letters, Vol. 181, No. 2, 25.02.1985, p. 357-361.

Research output: Contribution to journalArticle

Makarov, V. ; Dimitrov, S. ; Smirnov, V. ; Pashev, I. / A triple helix model for the structure of chromatin fiber. In: FEBS Letters. 1985 ; Vol. 181, No. 2. pp. 357-361.
@article{3e790f69071d4fe28f4c0966f77bad16,
title = "A triple helix model for the structure of chromatin fiber",
abstract = "A model of chromatin fiber structure is presented in which a repeating unit of a trinucleosome forms a 3-dimensional zigzag. Twisting and compression of the zigzag result in a triple helix structure. The model is built mainly on the flow linear dichroism data showing that (a) nucleosomal disc faces are tilted relative to the fiber axis, (b) the orientation of nucleosomes does not change upon folding and unfolding of chromatin, and (c) the orientation of nucleosomes is maintained by the globular domain of histone HI.",
keywords = "Chromatin structure Flow linear dichroism Nucleosome orientation Histone HI",
author = "V. Makarov and S. Dimitrov and V. Smirnov and I. Pashev",
year = "1985",
month = "2",
day = "25",
doi = "10.1016/0014-5793(85)80292-1",
language = "English",
volume = "181",
pages = "357--361",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - A triple helix model for the structure of chromatin fiber

AU - Makarov, V.

AU - Dimitrov, S.

AU - Smirnov, V.

AU - Pashev, I.

PY - 1985/2/25

Y1 - 1985/2/25

N2 - A model of chromatin fiber structure is presented in which a repeating unit of a trinucleosome forms a 3-dimensional zigzag. Twisting and compression of the zigzag result in a triple helix structure. The model is built mainly on the flow linear dichroism data showing that (a) nucleosomal disc faces are tilted relative to the fiber axis, (b) the orientation of nucleosomes does not change upon folding and unfolding of chromatin, and (c) the orientation of nucleosomes is maintained by the globular domain of histone HI.

AB - A model of chromatin fiber structure is presented in which a repeating unit of a trinucleosome forms a 3-dimensional zigzag. Twisting and compression of the zigzag result in a triple helix structure. The model is built mainly on the flow linear dichroism data showing that (a) nucleosomal disc faces are tilted relative to the fiber axis, (b) the orientation of nucleosomes does not change upon folding and unfolding of chromatin, and (c) the orientation of nucleosomes is maintained by the globular domain of histone HI.

KW - Chromatin structure Flow linear dichroism Nucleosome orientation Histone HI

UR - http://www.scopus.com/inward/record.url?scp=0021985925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021985925&partnerID=8YFLogxK

U2 - 10.1016/0014-5793(85)80292-1

DO - 10.1016/0014-5793(85)80292-1

M3 - Article

VL - 181

SP - 357

EP - 361

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 2

ER -