A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy

N. Papanas, A. J M Boulton, Rayaz Malik, C. Manes, O. Schnell, V. Spallone, N. Tentolouris, S. Tesfaye, P. Valensi, D. Ziegler, P. Kempler

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

A simple non-invasive indicator test (Neuropad®) has been developed for the assessment of sweating and, hence, cholinergic innervation in the diabetic foot. The present review summarizes current knowledge on this diagnostic test. The diagnostic ability of this test is based on a colour change from blue to pink at 10min, with excellent reproducibility, which lends itself to patient self-examination. It has a high sensitivity (65.1-100%) and negative predictive value (63-100%), with moderate specificity (32-78.5%) and positive predictive value (23.3-93.2%) for the diagnosis of diabetic peripheral neuropathy. It also has moderate to high sensitivity (59.1-89%) and negative predictive value (64.7-91%), but low to moderate specificity (27-78%) and positive predictive value (24-48.6%) for the diagnosis of diabetic cardiac autonomic neuropathy. There are some data to suggest that Neuropad can detect early diabetic neuropathy, but this needs further evaluation. It remains to be established whether this test can predict foot ulceration and amputation, thereby contributing to the identification of high-risk patients.

Original languageEnglish
Pages (from-to)525-534
Number of pages10
JournalDiabetic Medicine
Volume30
Issue number5
DOIs
Publication statusPublished - May 2013
Externally publishedYes

Fingerprint

Diabetic Neuropathies
Sweat
Routine Diagnostic Tests
Self-Examination
Diabetic Foot
Aptitude
Sweating
Peripheral Nervous System Diseases
Amputation
Cholinergic Agents
Foot
Color

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Papanas, N., Boulton, A. J. M., Malik, R., Manes, C., Schnell, O., Spallone, V., ... Kempler, P. (2013). A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy. Diabetic Medicine, 30(5), 525-534. https://doi.org/10.1111/dme.12000

A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy. / Papanas, N.; Boulton, A. J M; Malik, Rayaz; Manes, C.; Schnell, O.; Spallone, V.; Tentolouris, N.; Tesfaye, S.; Valensi, P.; Ziegler, D.; Kempler, P.

In: Diabetic Medicine, Vol. 30, No. 5, 05.2013, p. 525-534.

Research output: Contribution to journalReview article

Papanas, N, Boulton, AJM, Malik, R, Manes, C, Schnell, O, Spallone, V, Tentolouris, N, Tesfaye, S, Valensi, P, Ziegler, D & Kempler, P 2013, 'A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy', Diabetic Medicine, vol. 30, no. 5, pp. 525-534. https://doi.org/10.1111/dme.12000
Papanas, N. ; Boulton, A. J M ; Malik, Rayaz ; Manes, C. ; Schnell, O. ; Spallone, V. ; Tentolouris, N. ; Tesfaye, S. ; Valensi, P. ; Ziegler, D. ; Kempler, P. / A simple new non-invasive sweat indicator test for the diagnosis of diabetic neuropathy. In: Diabetic Medicine. 2013 ; Vol. 30, No. 5. pp. 525-534.
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