A search of superparamagnetic iron oxide-myoglobin as potential nanoparticle based magnetic resonance imaging marker in mouse heart imaging

Rakesh Sharma, Y. Haik, C. J. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Superparamagnetic iron oxide (Fe 2O 3) has emerged as potential MRI contrast agent in whole animal imaging to localize the site of clinically important physiological damage such as ischemia, angiogenesis, oxygen insufficiency, immunodeficiency. We achieved initial success in binding superparamagnetic iron oxide with myoglobin antibody (SPIOM) in order to develop it as possible MRI contrast agent. In this present paper, we highlight the possibility of using iron-oxide bound myoglobin antibody-gadolinium contrast agent to visualize mouse heart using 11.7 Tesla MRI magnet imager. To validate the MRI visualization, we captured the MRI image of a phantom in capillary filled with SPIOM. It can serve as guideline to measure the density distribution of different SPIOM amounts in the mouse body specially heart. We report the technical detail of SPIOM and its possible use in MRI as tool of visualizing mice heart and myocardium.

Original languageEnglish
Title of host publication2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Pages509-511
Number of pages3
Publication statusPublished - 8 Dec 2006
Event2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings - Boston, MA, United States
Duration: 7 May 200611 May 2006

Publication series

Name2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
Volume1

Other

Other2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
CountryUnited States
CityBoston, MA
Period7/5/0611/5/06

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Keywords

  • Heart
  • Iron-oxide
  • MRI
  • Mice
  • Myoglobin

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Sharma, R., Haik, Y., & Chen, C. J. (2006). A search of superparamagnetic iron oxide-myoglobin as potential nanoparticle based magnetic resonance imaging marker in mouse heart imaging. In 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings (pp. 509-511). (2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings; Vol. 1).