Higher Education Institutions (HEIs) hold an essential societal position as a micro model for the larger community of cities, countries, and the World in demonstrating a commitment to, contribution for, and transformational example of sustainability. HEIs have a significant prospect for enabling change towards a sustainable future and development. An extensive number of studies present sustainability ideation and implementation in HEIs with a large variety of approaches along with an emphasis on the main factors affecting its implementation. In addition, other studies report on different strategies used for aligning information systems (IS) with sustainability. This present study is a review aiming at investigating the existing gaps and identifying opportunities for future research towards developing an effective and integrated IS framework to enhance and support sustainability implementation in HEIs. Findings reveal that there is a necessity for further investigation on the linkage between all phases of implementing sustainability in HEIs through integrating sustainability and IS frameworks while considering all main factors that influence this shift.