A review of the molecular pathways mediating the improvement in diabetes mellitus following caloric restriction

Habib Yaribeygi, Stephen Atkin, Majid Ramezani, Amirhossein Sahebkar

Research output: Contribution to journalArticle

3 Citations (Scopus)


Lifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is difficult for patients to follow in practice, and remains critical to achieve optimal glucose homeostasis. In this review, we look at what is known about the molecular pathways involved in CR-induced insulin sensitivity and improved insulin resistance.

Original languageEnglish
JournalJournal of Cellular Physiology
Publication statusAccepted/In press - 1 Jan 2018



  • caloric restriction
  • diabetes mellitus
  • inflammation
  • insulin receptor substrate
  • insulin resistance
  • insulin sensitivity

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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