A registry of patients with severe deficiency of alpha1-antitrypsin: Design and methods

M. D. Schluchter, A. F. Barker, Ronald Crystal, R. A. Robbins, J. M. Stocks, J. K. Stoller, M. C. Wu, Z. Bengali, C. E. Vreim, A. Rothgeb, G. L. Snider, K. Detre, H. Y. Reynolds, M. S. Tockman, J. Wittes, A. S. Buist, B. Burrows, A. Cohen, R. J. Fallat

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Abstract

The Registry of Patients with Severe Deficiency of Alpha1-Antitrypsin (AIAT) is a multicenter natural history study, with 37 participating clinical centers in the United States (36 centers) and Canada (1 center). The study has enrolled 1,129 individuals aged ≥18 years with severe deficiency of AIAT (serum level ≤11 μM), and will follow them longitudinally for up to 7 years, characterizing the clinical course of the disease, regardless of whether they are receiving augmentation therapy. Primary outcomes of interest are the yearly decline in FEV1 and mortality. This article describes the design and structure of the Registry.

Original languageEnglish
Pages (from-to)1223-1232
Number of pages10
JournalChest
Volume106
Issue number4
Publication statusPublished - 1 Jan 1994
Externally publishedYes

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Keywords

  • alpha-antitrypsin
  • augmentation therapy
  • decline in lung function
  • design of studies
  • emphysema
  • longitudinal studies
  • registries
  • replacement therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Schluchter, M. D., Barker, A. F., Crystal, R., Robbins, R. A., Stocks, J. M., Stoller, J. K., Wu, M. C., Bengali, Z., Vreim, C. E., Rothgeb, A., Snider, G. L., Detre, K., Reynolds, H. Y., Tockman, M. S., Wittes, J., Buist, A. S., Burrows, B., Cohen, A., & Fallat, R. J. (1994). A registry of patients with severe deficiency of alpha1-antitrypsin: Design and methods. Chest, 106(4), 1223-1232.