A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

Martine I. Darville, Mohamed Chikri, Etienne Lebeau, Louis Hue, Guy G. Rousseau

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

There are at least 3 isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, a bifunctional enzyme which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate. A 22-kb rat gene that encodes the heart isozyme has been identified and compared with the 55-kb rat gene encoding the liver and muscle isozymes which had been described earlier. Although these 2 genes include 12 successive similar exons, they contain dissimilar exons at both ends, consistent with the occurrence of different regulatory domains at the N- and C-termini in the 3 isozymes.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalFEBS Letters
Volume288
Issue number1-2
Publication statusPublished - 19 Aug 1991
Externally publishedYes

Fingerprint

Phosphofructokinase-2
Gene encoding
Isoenzymes
Rats
Genes
Exons
Liver
Muscle
Degradation
Muscles
Enzymes

Keywords

  • 6-Phosphofructo-2-kinase
  • Fructose-2,6-bisphosphatase
  • Fructose-2,6-bisphosphate
  • Gene fusion
  • Glycolysis
  • Rat heart

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

Cite this

Darville, M. I., Chikri, M., Lebeau, E., Hue, L., & Rousseau, G. G. (1991). A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. FEBS Letters, 288(1-2), 91-94.

A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. / Darville, Martine I.; Chikri, Mohamed; Lebeau, Etienne; Hue, Louis; Rousseau, Guy G.

In: FEBS Letters, Vol. 288, No. 1-2, 19.08.1991, p. 91-94.

Research output: Contribution to journalArticle

Darville, MI, Chikri, M, Lebeau, E, Hue, L & Rousseau, GG 1991, 'A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase', FEBS Letters, vol. 288, no. 1-2, pp. 91-94.
Darville MI, Chikri M, Lebeau E, Hue L, Rousseau GG. A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. FEBS Letters. 1991 Aug 19;288(1-2):91-94.
Darville, Martine I. ; Chikri, Mohamed ; Lebeau, Etienne ; Hue, Louis ; Rousseau, Guy G. / A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. In: FEBS Letters. 1991 ; Vol. 288, No. 1-2. pp. 91-94.
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