A randomized controlled trial of low-dose prednisone and ciclosporin versus high-dose prednisone in nephrotic syndrome of children

A. Tejani, Manikkam Suthanthiran, A. Pomrantz

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Twenty-eight patients with an onset of nephrotic syndrome within 1 year were randomized to receive either ciclosporin and low-dose prednisone or high-dose prednisone alone. Both groups were treated for 8 weeks. Thirteen of 14 children receiving combined therapy underwent remission versus only 8 of 14 children receiving prednisone alone (p<0.05). However, there was no difference between the two groups as regards the duration of remission after discontinuation of therapy. In patients receiving combined therapy, immunological studies showed that high interleukin producers had a more sustained remission. There was no evidence of ciclosporin-induced nephrotoxicity in this short-term therapeutic trial.

Original languageEnglish
Pages (from-to)96-99
Number of pages4
JournalNephron
Volume59
Issue number1
Publication statusPublished - 1 Jan 1991
Externally publishedYes

Fingerprint

Nephrotic Syndrome
Prednisone
Cyclosporine
Randomized Controlled Trials
Interleukins
Therapeutics

Keywords

  • Ciclosporin
  • Nephrotic syndrome
  • Prednisone
  • Randomized trial

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Urology
  • Physiology (medical)

Cite this

A randomized controlled trial of low-dose prednisone and ciclosporin versus high-dose prednisone in nephrotic syndrome of children. / Tejani, A.; Suthanthiran, Manikkam; Pomrantz, A.

In: Nephron, Vol. 59, No. 1, 01.01.1991, p. 96-99.

Research output: Contribution to journalArticle

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