A randomized controlled trial of low-dose prednisone and ciclosporin versus high-dose prednisone in nephrotic syndrome of children

A. Tejani, Manikkam Suthanthiran, A. Pomrantz

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Abstract

Twenty-eight patients with an onset of nephrotic syndrome within 1 year were randomized to receive either ciclosporin and low-dose prednisone or high-dose prednisone alone. Both groups were treated for 8 weeks. Thirteen of 14 children receiving combined therapy underwent remission versus only 8 of 14 children receiving prednisone alone (p<0.05). However, there was no difference between the two groups as regards the duration of remission after discontinuation of therapy. In patients receiving combined therapy, immunological studies showed that high interleukin producers had a more sustained remission. There was no evidence of ciclosporin-induced nephrotoxicity in this short-term therapeutic trial.

Original languageEnglish
Pages (from-to)96-99
Number of pages4
JournalNephron
Volume59
Issue number1
Publication statusPublished - 1 Jan 1991
Externally publishedYes

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Keywords

  • Ciclosporin
  • Nephrotic syndrome
  • Prednisone
  • Randomized trial

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Urology
  • Physiology (medical)

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