Abstract
CYSTIC fibrosis is a lethal recessive genetic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator, a gene comprising 27 exons and 250 kilobases that resides on chromosome 7.1 2 3 4 5 The most important clinical manifestation of cystic fibrosis is chronic progressive lung disease, which despite aggressive antibiotic therapy and chest physiotherapy, remains the principal cause of disability and death.1 Airway secretions play a major part in the respiratory dysfunction in cystic fibrosis. The secretions are thick, viscous, and difficult to expectorate, and they obstruct airways and contribute to reduced lung volumes and expiratory flow rates.1,2,6 The presence of high.
| Original language | English |
|---|---|
| Pages (from-to) | 812-815 |
| Number of pages | 4 |
| Journal | New England Journal of Medicine |
| Volume | 326 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 19 Mar 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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A preliminary study of aerosolized recombinant human deoxyribonuclease i in the treatment of cystic fibrosis. / Hubbard, Richard C.; Mcelvaney, Noel G.; Birrer, Peter; Robinson, Woodrow W.; Jolley, Clara; Crystal, Ronald; Shak, Steven; wu, Margaret; Chernick, Milica S.
In: New England Journal of Medicine, Vol. 326, No. 12, 19.03.1992, p. 812-815.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A preliminary study of aerosolized recombinant human deoxyribonuclease i in the treatment of cystic fibrosis
AU - Hubbard, Richard C.
AU - Mcelvaney, Noel G.
AU - Birrer, Peter
AU - Robinson, Woodrow W.
AU - Jolley, Clara
AU - Crystal, Ronald
AU - Shak, Steven
AU - wu, Margaret
AU - Chernick, Milica S.
PY - 1992/3/19
Y1 - 1992/3/19
N2 - CYSTIC fibrosis is a lethal recessive genetic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator, a gene comprising 27 exons and 250 kilobases that resides on chromosome 7.1 2 3 4 5 The most important clinical manifestation of cystic fibrosis is chronic progressive lung disease, which despite aggressive antibiotic therapy and chest physiotherapy, remains the principal cause of disability and death.1 Airway secretions play a major part in the respiratory dysfunction in cystic fibrosis. The secretions are thick, viscous, and difficult to expectorate, and they obstruct airways and contribute to reduced lung volumes and expiratory flow rates.1,2,6 The presence of high.
AB - CYSTIC fibrosis is a lethal recessive genetic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator, a gene comprising 27 exons and 250 kilobases that resides on chromosome 7.1 2 3 4 5 The most important clinical manifestation of cystic fibrosis is chronic progressive lung disease, which despite aggressive antibiotic therapy and chest physiotherapy, remains the principal cause of disability and death.1 Airway secretions play a major part in the respiratory dysfunction in cystic fibrosis. The secretions are thick, viscous, and difficult to expectorate, and they obstruct airways and contribute to reduced lung volumes and expiratory flow rates.1,2,6 The presence of high.
UR - http://www.scopus.com/inward/record.url?scp=0026548151&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026548151&partnerID=8YFLogxK
U2 - 10.1056/NEJM199203193261207
DO - 10.1056/NEJM199203193261207
M3 - Article
C2 - 1538726
AN - SCOPUS:0026548151
VL - 326
SP - 812
EP - 815
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 12
ER -