A possible mechanism of renal cell death after ischemia/reperfusion

Peter M. Price, Rawad Hodeify

Research output: Contribution to journalComment/debate

16 Citations (Scopus)

Abstract

Linkermann et al. provide the first evidence for a possible biochemical mechanism of necrotic kidney cell death associated with renal ischemia/reperfusion-induced acute kidney injury. The mechanisms of several pathways resulting in programmed necrosis were recently elucidated and rely on receptor-interacting protein kinases 1 and 3. Using an inhibitor of one of these kinases, Linkermann et al. were able to ameliorate functional and morphologic kidney damage after ischemia/reperfusion.

Original languageEnglish
Pages (from-to)720-721
Number of pages2
JournalKidney International
Volume81
Issue number8
DOIs
Publication statusPublished - 2 Apr 2012
Externally publishedYes

Fingerprint

Reperfusion
Cell Death
Ischemia
Kidney
Receptor-Interacting Protein Serine-Threonine Kinases
Acute Kidney Injury
Protein Kinases
Necrosis
Phosphotransferases

ASJC Scopus subject areas

  • Nephrology

Cite this

A possible mechanism of renal cell death after ischemia/reperfusion. / Price, Peter M.; Hodeify, Rawad.

In: Kidney International, Vol. 81, No. 8, 02.04.2012, p. 720-721.

Research output: Contribution to journalComment/debate

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