A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders

Mònica Gratacòs, Marga Nadal, Rocío Martín-Santos, Miguel Angel Pujana, Jordi Gago, Belén Peral, Lluís Armengol, Immaculada Ponsa, Rosa Miró, Antoni Bulbena, Xavier Estivill

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

Anxiety disorders are complex and common psychiatric illnesses associated with considerable morbidity and social cost. We have studied the molecular basis of the cooccurrence of panic and phobic disorders with joint laxity. We have identified an interstitial duplication of human chromosome 15q24-26 (named DUP25), which is significantly associated with panic/agoraphobia/social phobia/joint laxity in families, and with panic disorder in nonfamilial cases. Mosaicism, different forms of DUP25 within the same family, and absence of segregation of 15q24-26 markers with DUP25 and the psychiatric phenotypes suggest a non-Mendelian mechanism of disease-causing mutation. We propose that DUP25, which is present in 7% control subjects, is a susceptibility factor for a clinical phenotype that includes panic and phobic disorders and joint laxity.

Original languageEnglish
Pages (from-to)367-379
Number of pages13
JournalCell
Volume106
Issue number3
DOIs
Publication statusPublished - 10 Aug 2001

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gratacòs, M., Nadal, M., Martín-Santos, R., Pujana, M. A., Gago, J., Peral, B., Armengol, L., Ponsa, I., Miró, R., Bulbena, A., & Estivill, X. (2001). A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders. Cell, 106(3), 367-379. https://doi.org/10.1016/S0092-8674(01)00447-0