A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung

Ronald Crystal, A. Jaffe, S. Brody, A. Mastrangeli, N. G. McElvaney, M. Rosenfeld, C. S. Chu, C. Danel, J. Hay, T. Eissa

Research output: Contribution to journalReview article

54 Citations (Scopus)
Original languageEnglish
Pages (from-to)643-666
Number of pages24
JournalHuman Gene Therapy
Volume6
Issue number5
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Fingerprint

Gene Transfer Techniques
Cystic Fibrosis Transmembrane Conductance Regulator
Genetic Vectors
Clinical Trials, Phase I
Nasal Mucosa
Bronchi
Regulator Genes
Patient Safety
Clinical Protocols
Virus Replication
Recombinant Proteins
Adenoviridae
Cystic Fibrosis
Genetic Therapy
Patient Selection
Epithelium
Complementary DNA
Lung

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung. / Crystal, Ronald; Jaffe, A.; Brody, S.; Mastrangeli, A.; McElvaney, N. G.; Rosenfeld, M.; Chu, C. S.; Danel, C.; Hay, J.; Eissa, T.

In: Human Gene Therapy, Vol. 6, No. 5, 01.01.1995, p. 643-666.

Research output: Contribution to journalReview article

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