A new class of immunosuppressants

Agents that induce erythroid differentiation in Friend leukemia cells inhibit cellular and humoral immune responses

Manikkam Suthanthiran, A. L. Rubin, A. Novogrodsky, K. H. Stenzel

Research output: Contribution to journalArticle

Abstract

Because of the obvious implications in terms of their potential as immunosuppressants, the present study was undertaken to investigate the basis for the immunosuppressive properties of two of the polar organic compounds that exhibited significant suppression of cellular and humoral immune responses. Butyric acid and dimethylsulfoxide are potent immunosuppressants capable of inhibiting a variety of immune responses relevant to organ transplantation. The cellular basis for suppression is secondary, at least in part, to inhibition of production of soluble factors pertinent to ultimate realization of such immune responses.

Original languageEnglish
Pages (from-to)576-577
Number of pages2
JournalTransplantation Proceedings
Volume15
Issue number1
Publication statusPublished - 1 Jan 1983
Externally publishedYes

Fingerprint

Immunosuppressive Agents
Humoral Immunity
Cellular Immunity
Leukemia
Butyric Acid
Organ Transplantation
Dimethyl Sulfoxide

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

A new class of immunosuppressants : Agents that induce erythroid differentiation in Friend leukemia cells inhibit cellular and humoral immune responses. / Suthanthiran, Manikkam; Rubin, A. L.; Novogrodsky, A.; Stenzel, K. H.

In: Transplantation Proceedings, Vol. 15, No. 1, 01.01.1983, p. 576-577.

Research output: Contribution to journalArticle

@article{6959dec58e1b4b398b0bcb4d467b20ba,
title = "A new class of immunosuppressants: Agents that induce erythroid differentiation in Friend leukemia cells inhibit cellular and humoral immune responses",
abstract = "Because of the obvious implications in terms of their potential as immunosuppressants, the present study was undertaken to investigate the basis for the immunosuppressive properties of two of the polar organic compounds that exhibited significant suppression of cellular and humoral immune responses. Butyric acid and dimethylsulfoxide are potent immunosuppressants capable of inhibiting a variety of immune responses relevant to organ transplantation. The cellular basis for suppression is secondary, at least in part, to inhibition of production of soluble factors pertinent to ultimate realization of such immune responses.",
author = "Manikkam Suthanthiran and Rubin, {A. L.} and A. Novogrodsky and Stenzel, {K. H.}",
year = "1983",
month = "1",
day = "1",
language = "English",
volume = "15",
pages = "576--577",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - A new class of immunosuppressants

T2 - Agents that induce erythroid differentiation in Friend leukemia cells inhibit cellular and humoral immune responses

AU - Suthanthiran, Manikkam

AU - Rubin, A. L.

AU - Novogrodsky, A.

AU - Stenzel, K. H.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Because of the obvious implications in terms of their potential as immunosuppressants, the present study was undertaken to investigate the basis for the immunosuppressive properties of two of the polar organic compounds that exhibited significant suppression of cellular and humoral immune responses. Butyric acid and dimethylsulfoxide are potent immunosuppressants capable of inhibiting a variety of immune responses relevant to organ transplantation. The cellular basis for suppression is secondary, at least in part, to inhibition of production of soluble factors pertinent to ultimate realization of such immune responses.

AB - Because of the obvious implications in terms of their potential as immunosuppressants, the present study was undertaken to investigate the basis for the immunosuppressive properties of two of the polar organic compounds that exhibited significant suppression of cellular and humoral immune responses. Butyric acid and dimethylsulfoxide are potent immunosuppressants capable of inhibiting a variety of immune responses relevant to organ transplantation. The cellular basis for suppression is secondary, at least in part, to inhibition of production of soluble factors pertinent to ultimate realization of such immune responses.

UR - http://www.scopus.com/inward/record.url?scp=0020581510&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020581510&partnerID=8YFLogxK

M3 - Article

VL - 15

SP - 576

EP - 577

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 1

ER -