A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein β-secretase

A. Solans, Xavier P. Estivill, Susana De La Luna

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Down syndrome individuals develop abnormalities of most organs, including all the pathological and neurochemical features of Alzheimer's disease, by the early age of 30 yr. Here, we report the isolation and characterization of BACE2, a gene mapping on human chromosome 21q22.3, which is highly similar to a transmembrane aspartyl protease, BACE (for beta-site APP-cleaving enzyme), which is able to catalyze the β-secretase cleavage of Alzheimer's amyloid precursor protein (APP). BACE2 is expressed in a wide variety of organs and tissues, with several transcripts due to alternative splicing and the use of two polyadenylation signals. The BACE2 gene product is a 518 amino acid protein with the signature of an aspartic protease, a 20- residue signal peptide, and two putative N-glycosylation sites. In addition, and similarly to BACE, BACE2 differs from the other members of the human aspartic protease family in the number and distribution of putative disulfide bonds and in the presence of an extended C-terminal region which contains a predicted transmembrane segment. BACE2 could be involved in the Alzheimer- like neuropathology of Down syndrome, as well as in Alzheimer's disease linked to chromosome 21 but not showing mutations in APP. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalCytogenetics and Cell Genetics
Volume89
Issue number3-4
Publication statusPublished - 2000
Externally publishedYes

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Aspartic Acid Proteases
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Down Syndrome
Alzheimer Disease
Peptide Hydrolases
Chromosomes, Human, Pair 21
Polyadenylation
Chromosome Mapping
Alternative Splicing
Human Chromosomes
Enzymes
Protein Sorting Signals
Glycosylation
Disulfides
Amino Acids
Mutation
Genes
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein β-secretase. / Solans, A.; Estivill, Xavier P.; De La Luna, Susana.

In: Cytogenetics and Cell Genetics, Vol. 89, No. 3-4, 2000, p. 177-184.

Research output: Contribution to journalArticle

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