A Model for Transfer of P-Glycoproteins in MCF-7 Breast Cancer Cell Line with Multiple Transfer Rules

P. Magal, A. Noussair, Jennifer Pasquier, P. Zongo, F. Le Foll

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this paper, we consider a direct protein transfer process between cells in co-culture. Assuming that cells continually encounter each other, and from some hypotheses on cell-to-cell rules of transfer, we derive discrete and continuous Boltzmann-like integro-differential equations. The novelty of this model is to take into account multiple transfer rules. This new transfer model is used to fit the experimental data of cell-to-cell protein transfer in breast cancer.

Original languageEnglish
Pages (from-to)2049-2067
Number of pages19
JournalBulletin of Mathematical Biology
Volume79
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017

Fingerprint

P-Glycoproteins
Glycoproteins
Glycoprotein
Breast Cancer
breast neoplasms
cancer
Cells
cell lines
Breast Neoplasms
Proteins
Cell Line
protein
Integrodifferential equations
Line
Cell
cells
Co-culture
Model
Protein
coculture

Keywords

  • Breast cancer cells
  • Discrete and continuous models
  • Protein transfers

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics

Cite this

A Model for Transfer of P-Glycoproteins in MCF-7 Breast Cancer Cell Line with Multiple Transfer Rules. / Magal, P.; Noussair, A.; Pasquier, Jennifer; Zongo, P.; Le Foll, F.

In: Bulletin of Mathematical Biology, Vol. 79, No. 9, 01.09.2017, p. 2049-2067.

Research output: Contribution to journalArticle

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