A Model for Transfer of P-Glycoproteins in MCF-7 Breast Cancer Cell Line with Multiple Transfer Rules

P. Magal, A. Noussair, Jennifer Pasquier, P. Zongo, F. Le Foll

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In this paper, we consider a direct protein transfer process between cells in co-culture. Assuming that cells continually encounter each other, and from some hypotheses on cell-to-cell rules of transfer, we derive discrete and continuous Boltzmann-like integro-differential equations. The novelty of this model is to take into account multiple transfer rules. This new transfer model is used to fit the experimental data of cell-to-cell protein transfer in breast cancer.

Original languageEnglish
Pages (from-to)2049-2067
Number of pages19
JournalBulletin of Mathematical Biology
Volume79
Issue number9
DOIs
Publication statusPublished - 1 Sep 2017

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Keywords

  • Breast cancer cells
  • Discrete and continuous models
  • Protein transfers

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Mathematics(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Pharmacology
  • Agricultural and Biological Sciences(all)
  • Computational Theory and Mathematics

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