A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction

Jacquelyn Y. Taylor, Karen Schwander, Sharon L R Kardia, Donna Arnett, Jingjing Liang, Steven Hunt, D. C. Rao, Yan V. Sun

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cigarette smoking has been shown to be a health hazard. In addition to being considered a negative lifestyle behavior, studies have shown that cigarette smoking has been linked to genetic underpinnings of hypertension. Because African Americans have the highest incidence and prevalence of hypertension, we examined the joint effect of genetics and cigarette smoking on health among this understudied population. The sample included African Americans from the genome wide association studies of HyperGEN (N = 1083, discovery sample) and GENOA (N = 1427, replication sample), both part of the FBPP. Results suggested that 2 SNPs located on chromosomes 14 (NEDD8; rs11158609; raw p = 9.80 × 10 -9, genomic control-adjusted p = 2.09 × 10 -7) and 17 (TTYH2; rs8078051; raw p = 6.28 × 10 -8, genomic control-adjusted p = 9.65 × 10 -7) were associated with SBP including the genetic interaction with cigarette smoking. These two SNPs were not associated with SBP in a main genetic effect only model. This study advances knowledge in the area of main and joint effects of genetics and cigarette smoking on hypertension among African Americans and offers a model to the reader for assessing these risks. More research is required to determine how these genes play a role in expression of hypertension.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 11 Jan 2016
Externally publishedYes

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African Americans
Smoking
Genome
Blood Pressure
Hypertension
Genes
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 14
Genome-Wide Association Study
Health
Life Style
Incidence
Research
Population

ASJC Scopus subject areas

  • General

Cite this

Taylor, J. Y., Schwander, K., Kardia, S. L. R., Arnett, D., Liang, J., Hunt, S., ... Sun, Y. V. (2016). A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction. Scientific Reports, 6, 1-10. https://doi.org/10.1038/srep18812

A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction. / Taylor, Jacquelyn Y.; Schwander, Karen; Kardia, Sharon L R; Arnett, Donna; Liang, Jingjing; Hunt, Steven; Rao, D. C.; Sun, Yan V.

In: Scientific Reports, Vol. 6, 11.01.2016, p. 1-10.

Research output: Contribution to journalArticle

Taylor, JY, Schwander, K, Kardia, SLR, Arnett, D, Liang, J, Hunt, S, Rao, DC & Sun, YV 2016, 'A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction', Scientific Reports, vol. 6, pp. 1-10. https://doi.org/10.1038/srep18812
Taylor, Jacquelyn Y. ; Schwander, Karen ; Kardia, Sharon L R ; Arnett, Donna ; Liang, Jingjing ; Hunt, Steven ; Rao, D. C. ; Sun, Yan V. / A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction. In: Scientific Reports. 2016 ; Vol. 6. pp. 1-10.
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