A genome-wide association study of metabolic traits in human urine

Karsten Suhre, Henri Wallaschofski, Johannes Raffler, Nele Friedrich, Robin Haring, Kathrin Michael, Christina Wasner, Alexander Krebs, Florian Kronenberg, David Chang, Christa Meisinger, H. Erich Wichmann, Wolfgang Hoffmann, Henry Völzke, Uwe Völker, Alexander Teumer, Reiner Biffar, Thomas Kocher, Stephan B. Felix, Thomas IlligHeyo K. Kroemer, Christian Gieger, Werner Römisch-Margl, Matthias Nauck

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Abstract

We present a genome-wide association study of metabolic traits in human urine, designed to investigate the detoxification capacity of the human body. Using NMR spectroscopy, we tested for associations between 59 metabolites in urine from 862 male participants in the population-based SHIP study. We replicated the results using 1,039 additional samples of the same study, including a 5-year follow-up, and 992 samples from the independent KORA study. We report five loci with joint P values of association from 3.2 × 10- 19 to 2.1 × 10-182. Variants at three of these loci have previously been linked with important clinical outcomes: SLC7A9 is a risk locus for chronic kidney disease, NAT2 for coronary artery disease and genotype-dependent response to drug toxicity, and SLC6A20 for iminoglycinuria. Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper- 2-aminoisobutyric aciduria.

Original languageEnglish
Pages (from-to)565-569
Number of pages5
JournalNature Genetics
Volume43
Issue number6
DOIs
Publication statusPublished - Jun 2011
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics

Cite this

Suhre, K., Wallaschofski, H., Raffler, J., Friedrich, N., Haring, R., Michael, K., Wasner, C., Krebs, A., Kronenberg, F., Chang, D., Meisinger, C., Wichmann, H. E., Hoffmann, W., Völzke, H., Völker, U., Teumer, A., Biffar, R., Kocher, T., Felix, S. B., ... Nauck, M. (2011). A genome-wide association study of metabolic traits in human urine. Nature Genetics, 43(6), 565-569. https://doi.org/10.1038/ng.837