A genome-wide affected sibpair linkage analysis of hypertension: The HyperGEN Network

Dabeeru C. Rao, Michael A. Province, Mark F. Leppert, Al Oberman, Gerardo Heiss, R. Curt Ellison, Donna K. Arnett, John H. Eckfeldt, Karen Schwander, Steve C. Mockrin, Steven Hunt

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Results are reported here from a genome-wide linkage analysis of hypertension in a large sample of hypertensive (affected) sibpairs (650 African American and 915 white sibpairs) recruited by the HyperGEN Network of the National Heart, Lung and Blood Institute (NHLBI) Family Blood Pressure Program (FBPP). Analysis using MAPMAKER/SIBS suggests one interesting region with a LOD score of 2.08 at 63 cM from the p telomere on chromosome 2 in the African American sibpairs, which may harbor hypertension susceptibility genes.

Original languageEnglish
Pages (from-to)148-150
Number of pages3
JournalAmerican Journal of Hypertension
Volume16
Issue number2
DOIs
Publication statusPublished - 1 Feb 2003
Externally publishedYes

Fingerprint

African Americans
Genome
Hypertension
National Heart, Lung, and Blood Institute (U.S.)
Chromosomes, Human, Pair 2
Telomere
Blood Pressure
Genes

Keywords

  • Genetics
  • Hypertension
  • Linkage

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A genome-wide affected sibpair linkage analysis of hypertension : The HyperGEN Network. / Rao, Dabeeru C.; Province, Michael A.; Leppert, Mark F.; Oberman, Al; Heiss, Gerardo; Ellison, R. Curt; Arnett, Donna K.; Eckfeldt, John H.; Schwander, Karen; Mockrin, Steve C.; Hunt, Steven.

In: American Journal of Hypertension, Vol. 16, No. 2, 01.02.2003, p. 148-150.

Research output: Contribution to journalArticle

Rao, DC, Province, MA, Leppert, MF, Oberman, A, Heiss, G, Ellison, RC, Arnett, DK, Eckfeldt, JH, Schwander, K, Mockrin, SC & Hunt, S 2003, 'A genome-wide affected sibpair linkage analysis of hypertension: The HyperGEN Network', American Journal of Hypertension, vol. 16, no. 2, pp. 148-150. https://doi.org/10.1016/S0895-7061(02)03247-8
Rao, Dabeeru C. ; Province, Michael A. ; Leppert, Mark F. ; Oberman, Al ; Heiss, Gerardo ; Ellison, R. Curt ; Arnett, Donna K. ; Eckfeldt, John H. ; Schwander, Karen ; Mockrin, Steve C. ; Hunt, Steven. / A genome-wide affected sibpair linkage analysis of hypertension : The HyperGEN Network. In: American Journal of Hypertension. 2003 ; Vol. 16, No. 2. pp. 148-150.
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