A functional polymorphism of the tumor necrosis factor receptor-II gene associated with the survival and relapse prediction of breast carcinoma

Souhir Mestiri, Noureddine Bouaouina, Slim Ben Ahmed, Lotfi Chouchane

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16 Citations (Scopus)

Abstract

Objective: Recently, we showed the implication of the polymorphism in tumor necrosis factor-alpha (TNF-α) gene in the susceptibility and prognosis of breast carcinoma. TNF-α acts through its receptors: types I and II. The TNFRII, expressed on the haematopoietic cells, is the high affinity receptor involved in mediating the biological effects of TNF-α. We investigated the susceptibility and prognostic implications of the genetic variation in the TNFRII in breast carcinoma. Methods: We used the polymerase chain reaction and restriction enzyme digestion to characterize the variation of the TNFRII gene in 300 unrelated Tunisian patients with breast carcinoma and 200 healthy control subjects. Associations of the genetic marker with the rates of the breast carcinoma-specific overall survival and the disease-free survival were assessed. Results: A significant association was found between TNFRII-196M/R heterozygous genotype and breast carcinoma (OR = 1.61; P = 0.02). This association was more significant in post-menopausal patients (OR = 2.41, P = 0.0001). The 196R-TNFRII allele showed a significant association with increased overall survival and disease-free survival in breast carcinoma patients. Conclusion: Genetic variation in TNFRII may predict the late onset of breast carcinoma, relapse and death for patients with breast carcinoma.

Original languageEnglish
Pages (from-to)182-187
Number of pages6
JournalCytokine
Volume30
Issue number4
DOIs
Publication statusPublished - 21 May 2005
Externally publishedYes

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Keywords

  • Breast carcinoma
  • Polymorphism
  • Prognosis
  • Susceptibility
  • TNF receptor
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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