A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects

David M. Mutch, Tune H. Pers, Ramzi Temanni, Veronique Pelloux, Adriana Marquez-Quinõnes, Claus Holst, J. Alfredo Martinez, Dimitris Babalis, Marleen A. Van Baak, Teodora Handjieva-Darlenska, Celia G. Walker, Arne Astrup, Wim H M Saris, Dominique Langin, Nathalie Viguerie, Jean Daniel Zucker, Karine Cleḿent

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Weight loss has been shown to reduce risk factors associated with cardiovascular disease and diabetes; however, successful maintenance of weight loss continues to pose a challenge. Objective: The present study was designed to assess whether changes in subcutaneous adipose tissue (scAT) gene expression during a low-calorie diet (LCD) could be used to differentiate and predict subjects who experience successful short-term weight maintenance from subjects who experience weight regain. Design: Forty white women followed a dietary protocol consisting of an 8-wk LCD phase followed by a 6-mo weight-maintenance phase. Participants were classified as weight maintainers (WMs; 0-10% weight regain) and weight regainers (WRs; 50-100% weight regain) by considering changes in body weight during the 2 phases. Anthropometric measurements, bioclinical variables, and scAT gene expression were studied in all individuals before and after the LCD. Energy intake was estimated by using 3-d dietary records. Results: No differences in body weight and fasting insulin were observed between WMs and WRs at baseline or after the LCD period. The LCD resulted in significant decreases in body weight and in several plasma variables in both groups. WMs experienced a significant reduction in insulin secretion in response to an oralglucose-tolerance test after the LCD; in contrast, no changes in insulin secretion were observed in WRs after the LCD. An ANOVA of scAT gene expression showed that genes regulating fatty acid metabolism, citric acid cycle, oxidative phosphorylation, and apoptosis were regulated differently by the LCD in WM and WR subjects. Conclusion: This study suggests that LCD-induced changes in insulin secretion and scAT gene expression may have the potential to predict successful short-term weight maintenance. This trial was registered at clinicaltrials.gov as NCT00390637.

Original languageEnglish
Pages (from-to)1399-1409
Number of pages11
JournalAmerican Journal of Clinical Nutrition
Volume94
Issue number6
DOIs
Publication statusPublished - 1 Dec 2011
Externally publishedYes

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Caloric Restriction
Adipose Tissue
Maintenance
Gene Expression
Weights and Measures
Subcutaneous Fat
Insulin
Weight Loss
Body Weight
Diet Records
Body Weight Changes
Citric Acid Cycle
Oxidative Phosphorylation
Energy Intake
Fasting
Analysis of Variance
Cardiovascular Diseases
Fatty Acids
Apoptosis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects. / Mutch, David M.; Pers, Tune H.; Temanni, Ramzi; Pelloux, Veronique; Marquez-Quinõnes, Adriana; Holst, Claus; Martinez, J. Alfredo; Babalis, Dimitris; Van Baak, Marleen A.; Handjieva-Darlenska, Teodora; Walker, Celia G.; Astrup, Arne; Saris, Wim H M; Langin, Dominique; Viguerie, Nathalie; Zucker, Jean Daniel; Cleḿent, Karine.

In: American Journal of Clinical Nutrition, Vol. 94, No. 6, 01.12.2011, p. 1399-1409.

Research output: Contribution to journalArticle

Mutch, DM, Pers, TH, Temanni, R, Pelloux, V, Marquez-Quinõnes, A, Holst, C, Martinez, JA, Babalis, D, Van Baak, MA, Handjieva-Darlenska, T, Walker, CG, Astrup, A, Saris, WHM, Langin, D, Viguerie, N, Zucker, JD & Cleḿent, K 2011, 'A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects', American Journal of Clinical Nutrition, vol. 94, no. 6, pp. 1399-1409. https://doi.org/10.3945/ajcn.110.006858
Mutch, David M. ; Pers, Tune H. ; Temanni, Ramzi ; Pelloux, Veronique ; Marquez-Quinõnes, Adriana ; Holst, Claus ; Martinez, J. Alfredo ; Babalis, Dimitris ; Van Baak, Marleen A. ; Handjieva-Darlenska, Teodora ; Walker, Celia G. ; Astrup, Arne ; Saris, Wim H M ; Langin, Dominique ; Viguerie, Nathalie ; Zucker, Jean Daniel ; Cleḿent, Karine. / A distinct adipose tissue gene expression response to caloric restriction predicts 6-mo weight maintenance in obese subjects. In: American Journal of Clinical Nutrition. 2011 ; Vol. 94, No. 6. pp. 1399-1409.
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AU - Martinez, J. Alfredo

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