The objective of the study is to analyze three-dimensional fluid flow through annular pipeline with multiphase fluids using Computational Fluid Dynamics (CFD) simulation. ANSYS Fluent version 16 platform is used to perform the simulation. Eulerian model with Reynolds Stress Model (RSM) turbulence closure is adopted to analyze multiphase fluid flow in annular flow line. The results are validated with existing experimental data and empirical correlations. A robust simulation model is developed that can be used further for different applied cases. Geometry and boundary conditions of flow are adopted from experimental works to validate the simulation. The sensitivity analysis is also conducted to observe the flow characteristics. Fluid inlet velocity of distinct phases, inner pipe rotation and eccentricity are used as input or independent parameter and pressure gradient (pressure loss per unit length) and local concentration profile at different sections of geometry are the primary output parameter to analyze. The key results show that changing inner pipe rotation and eccentricity have a significant impact on output pressure and local particle distribution which eventually help to find way out from particle blockage. The outcome of this study will help oil and gas industry in designing the pipeline.