3DCoffeeιgs: A web server for combining sequences and structures into a multiple sequence alignment

Oliver Poirot, Karsten Suhre, Chantal Abergel, Eamonn O'Toole, Cedric Notredame

Research output: Contribution to journalArticle

130 Citations (Scopus)


This paper presents 3DCoffeeιgs, a web-based tool dedicated to the computation of high-quality multiple sequence alignments (MSAs). 3D-Coffee makes it possible to mix protein sequences and structures in order to increase the accuracy of the alignments. Structures can be either provided as PDB identifiers or directly uploaded into the server. Given a set of sequences and structures, pairs of structures are aligned with SAP while sequence-structure pairs are aligned with Fugue. The resulting collection of pairwise alignments is then combined into an MSA with the T-Coffee algorithm. The server and its documentation are available from http://igs-server.cnrs-mrs.fr/Tcoffee/.

Original languageEnglish
Pages (from-to)W37-W40
JournalNucleic acids research
Issue numberWEB SERVER ISS.
Publication statusPublished - 1 Jul 2004


ASJC Scopus subject areas

  • Genetics

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