30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

Qian Zhang, Michael J. Lenardo, David Baltimore

Research output: Contribution to journalReview article

362 Citations (Scopus)

Abstract

NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.

Original languageEnglish
Pages (from-to)37-57
Number of pages21
JournalCell
Volume168
Issue number1-2
DOIs
Publication statusPublished - 12 Jan 2017

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Keywords

  • gene regulation
  • genetic disease
  • genomics
  • human gene
  • I-κB
  • immunity
  • lymphocyte
  • NF-κB
  • Rel
  • transactivator

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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