1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control

Dennis O. Mook-Kanamori, Mohammed M. El-Din Selim, Ahmed H. Takiddin, Hala Al-Homsi, Khoulood A S Al-Mahmoud, Amina Al-Obaidli, Mahmoud A. Zirie, Jillian Rowe, Noha Yousri, Edward D. Karoly, Thomas Kocher, Wafaa Sekkal Gherbi, Omar Chidiac, Marjonneke J. Mook-Kanamori, Sara Abdulkader, Wadha A. Al Muftah, Cindy McKeon, Karsten Suhre

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Context: In most ethnicities at least a quarter of all cases with diabetes is assumed to be undiagnosed. Screening for diabetes using saliva has been suggested as an effective approach to identify affected individuals. Objective: The objective of the study was to identify a noninvasive metabolic marker of type 2 diabetes in saliva. Design and Setting: In a case-control study of type 2 diabetes, we used a clinical metabolomics discovery study to screen for diabetes-relevant metabolic readouts in saliva, using blood and urine as a reference. With a combination of three metabolomics platforms based on nontargeted mass spectrometry, we examined 2178 metabolites in saliva, blood plasma, and urine samples from 188 subjects with type 2 diabetes and 181 controls of Arab and Asian ethnicities. Results: We found a strong association of type 2 diabetes with 1,5-anhydroglucitol (1,5-AG) in saliva (P = 3.6 × 10-13). Levels of 1,5-AG in saliva highly correlated with 1,5-AG levels in blood and inversely correlated with blood glucose and glycosylated hemoglobin levels. These findings were robust across three different non-Caucasian ethnicities (Arabs, South Asians, and Filipinos), irrespective of body mass index, age, and gender. Conclusions: Clinical studieshavealready established 1,5-AG inbloodasareliablemarkerof short-term glycemic control. Our study suggests that 1,5-AG in saliva can be used in national screening programs for undiagnosed diabetes, which are of particular interest for Middle Eastern countries with young populations and exceptionally high diabetes rates.

Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Medical problems
Saliva
Type 2 Diabetes Mellitus
Metabolomics
Blood
Urine
Screening
Glycosylated Hemoglobin A
1,5-anhydroglucitol
Blood Glucose
Case-Control Studies
Mass Spectrometry
Body Mass Index
Metabolites
Mass spectrometry
Plasmas
Population

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Mook-Kanamori, D. O., El-Din Selim, M. M., Takiddin, A. H., Al-Homsi, H., Al-Mahmoud, K. A. S., Al-Obaidli, A., ... Suhre, K. (2014). 1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control. Journal of Clinical Endocrinology and Metabolism, 99(3). https://doi.org/10.1210/jc.2013-3596

1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control. / Mook-Kanamori, Dennis O.; El-Din Selim, Mohammed M.; Takiddin, Ahmed H.; Al-Homsi, Hala; Al-Mahmoud, Khoulood A S; Al-Obaidli, Amina; Zirie, Mahmoud A.; Rowe, Jillian; Yousri, Noha; Karoly, Edward D.; Kocher, Thomas; Gherbi, Wafaa Sekkal; Chidiac, Omar; Mook-Kanamori, Marjonneke J.; Abdulkader, Sara; Al Muftah, Wadha A.; McKeon, Cindy; Suhre, Karsten.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 3, 2014.

Research output: Contribution to journalArticle

Mook-Kanamori, DO, El-Din Selim, MM, Takiddin, AH, Al-Homsi, H, Al-Mahmoud, KAS, Al-Obaidli, A, Zirie, MA, Rowe, J, Yousri, N, Karoly, ED, Kocher, T, Gherbi, WS, Chidiac, O, Mook-Kanamori, MJ, Abdulkader, S, Al Muftah, WA, McKeon, C & Suhre, K 2014, '1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control', Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 3. https://doi.org/10.1210/jc.2013-3596
Mook-Kanamori DO, El-Din Selim MM, Takiddin AH, Al-Homsi H, Al-Mahmoud KAS, Al-Obaidli A et al. 1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control. Journal of Clinical Endocrinology and Metabolism. 2014;99(3). https://doi.org/10.1210/jc.2013-3596
Mook-Kanamori, Dennis O. ; El-Din Selim, Mohammed M. ; Takiddin, Ahmed H. ; Al-Homsi, Hala ; Al-Mahmoud, Khoulood A S ; Al-Obaidli, Amina ; Zirie, Mahmoud A. ; Rowe, Jillian ; Yousri, Noha ; Karoly, Edward D. ; Kocher, Thomas ; Gherbi, Wafaa Sekkal ; Chidiac, Omar ; Mook-Kanamori, Marjonneke J. ; Abdulkader, Sara ; Al Muftah, Wadha A. ; McKeon, Cindy ; Suhre, Karsten. / 1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control. In: Journal of Clinical Endocrinology and Metabolism. 2014 ; Vol. 99, No. 3.
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AU - Mook-Kanamori, Dennis O.

AU - El-Din Selim, Mohammed M.

AU - Takiddin, Ahmed H.

AU - Al-Homsi, Hala

AU - Al-Mahmoud, Khoulood A S

AU - Al-Obaidli, Amina

AU - Zirie, Mahmoud A.

AU - Rowe, Jillian

AU - Yousri, Noha

AU - Karoly, Edward D.

AU - Kocher, Thomas

AU - Gherbi, Wafaa Sekkal

AU - Chidiac, Omar

AU - Mook-Kanamori, Marjonneke J.

AU - Abdulkader, Sara

AU - Al Muftah, Wadha A.

AU - McKeon, Cindy

AU - Suhre, Karsten

PY - 2014

Y1 - 2014

N2 - Context: In most ethnicities at least a quarter of all cases with diabetes is assumed to be undiagnosed. Screening for diabetes using saliva has been suggested as an effective approach to identify affected individuals. Objective: The objective of the study was to identify a noninvasive metabolic marker of type 2 diabetes in saliva. Design and Setting: In a case-control study of type 2 diabetes, we used a clinical metabolomics discovery study to screen for diabetes-relevant metabolic readouts in saliva, using blood and urine as a reference. With a combination of three metabolomics platforms based on nontargeted mass spectrometry, we examined 2178 metabolites in saliva, blood plasma, and urine samples from 188 subjects with type 2 diabetes and 181 controls of Arab and Asian ethnicities. Results: We found a strong association of type 2 diabetes with 1,5-anhydroglucitol (1,5-AG) in saliva (P = 3.6 × 10-13). Levels of 1,5-AG in saliva highly correlated with 1,5-AG levels in blood and inversely correlated with blood glucose and glycosylated hemoglobin levels. These findings were robust across three different non-Caucasian ethnicities (Arabs, South Asians, and Filipinos), irrespective of body mass index, age, and gender. Conclusions: Clinical studieshavealready established 1,5-AG inbloodasareliablemarkerof short-term glycemic control. Our study suggests that 1,5-AG in saliva can be used in national screening programs for undiagnosed diabetes, which are of particular interest for Middle Eastern countries with young populations and exceptionally high diabetes rates.

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