Abstract
Context: In most ethnicities at least a quarter of all cases with diabetes is assumed to be undiagnosed. Screening for diabetes using saliva has been suggested as an effective approach to identify affected individuals. Objective: The objective of the study was to identify a noninvasive metabolic marker of type 2 diabetes in saliva. Design and Setting: In a case-control study of type 2 diabetes, we used a clinical metabolomics discovery study to screen for diabetes-relevant metabolic readouts in saliva, using blood and urine as a reference. With a combination of three metabolomics platforms based on nontargeted mass spectrometry, we examined 2178 metabolites in saliva, blood plasma, and urine samples from 188 subjects with type 2 diabetes and 181 controls of Arab and Asian ethnicities. Results: We found a strong association of type 2 diabetes with 1,5-anhydroglucitol (1,5-AG) in saliva (P = 3.6 × 10-13). Levels of 1,5-AG in saliva highly correlated with 1,5-AG levels in blood and inversely correlated with blood glucose and glycosylated hemoglobin levels. These findings were robust across three different non-Caucasian ethnicities (Arabs, South Asians, and Filipinos), irrespective of body mass index, age, and gender. Conclusions: Clinical studieshavealready established 1,5-AG inbloodasareliablemarkerof short-term glycemic control. Our study suggests that 1,5-AG in saliva can be used in national screening programs for undiagnosed diabetes, which are of particular interest for Middle Eastern countries with young populations and exceptionally high diabetes rates.
| Original language | English |
|---|---|
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 99 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 |
Fingerprint
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical
Cite this
1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control. / Mook-Kanamori, Dennis O.; El-Din Selim, Mohammed M.; Takiddin, Ahmed H.; Al-Homsi, Hala; Al-Mahmoud, Khoulood A S; Al-Obaidli, Amina; Zirie, Mahmoud A.; Rowe, Jillian; Yousri, Noha; Karoly, Edward D.; Kocher, Thomas; Gherbi, Wafaa Sekkal; Chidiac, Omar; Mook-Kanamori, Marjonneke J.; Abdulkader, Sara; Al Muftah, Wadha A.; McKeon, Cindy; Suhre, Karsten.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 3, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control
AU - Mook-Kanamori, Dennis O.
AU - El-Din Selim, Mohammed M.
AU - Takiddin, Ahmed H.
AU - Al-Homsi, Hala
AU - Al-Mahmoud, Khoulood A S
AU - Al-Obaidli, Amina
AU - Zirie, Mahmoud A.
AU - Rowe, Jillian
AU - Yousri, Noha
AU - Karoly, Edward D.
AU - Kocher, Thomas
AU - Gherbi, Wafaa Sekkal
AU - Chidiac, Omar
AU - Mook-Kanamori, Marjonneke J.
AU - Abdulkader, Sara
AU - Al Muftah, Wadha A.
AU - McKeon, Cindy
AU - Suhre, Karsten
PY - 2014
Y1 - 2014
N2 - Context: In most ethnicities at least a quarter of all cases with diabetes is assumed to be undiagnosed. Screening for diabetes using saliva has been suggested as an effective approach to identify affected individuals. Objective: The objective of the study was to identify a noninvasive metabolic marker of type 2 diabetes in saliva. Design and Setting: In a case-control study of type 2 diabetes, we used a clinical metabolomics discovery study to screen for diabetes-relevant metabolic readouts in saliva, using blood and urine as a reference. With a combination of three metabolomics platforms based on nontargeted mass spectrometry, we examined 2178 metabolites in saliva, blood plasma, and urine samples from 188 subjects with type 2 diabetes and 181 controls of Arab and Asian ethnicities. Results: We found a strong association of type 2 diabetes with 1,5-anhydroglucitol (1,5-AG) in saliva (P = 3.6 × 10-13). Levels of 1,5-AG in saliva highly correlated with 1,5-AG levels in blood and inversely correlated with blood glucose and glycosylated hemoglobin levels. These findings were robust across three different non-Caucasian ethnicities (Arabs, South Asians, and Filipinos), irrespective of body mass index, age, and gender. Conclusions: Clinical studieshavealready established 1,5-AG inbloodasareliablemarkerof short-term glycemic control. Our study suggests that 1,5-AG in saliva can be used in national screening programs for undiagnosed diabetes, which are of particular interest for Middle Eastern countries with young populations and exceptionally high diabetes rates.
AB - Context: In most ethnicities at least a quarter of all cases with diabetes is assumed to be undiagnosed. Screening for diabetes using saliva has been suggested as an effective approach to identify affected individuals. Objective: The objective of the study was to identify a noninvasive metabolic marker of type 2 diabetes in saliva. Design and Setting: In a case-control study of type 2 diabetes, we used a clinical metabolomics discovery study to screen for diabetes-relevant metabolic readouts in saliva, using blood and urine as a reference. With a combination of three metabolomics platforms based on nontargeted mass spectrometry, we examined 2178 metabolites in saliva, blood plasma, and urine samples from 188 subjects with type 2 diabetes and 181 controls of Arab and Asian ethnicities. Results: We found a strong association of type 2 diabetes with 1,5-anhydroglucitol (1,5-AG) in saliva (P = 3.6 × 10-13). Levels of 1,5-AG in saliva highly correlated with 1,5-AG levels in blood and inversely correlated with blood glucose and glycosylated hemoglobin levels. These findings were robust across three different non-Caucasian ethnicities (Arabs, South Asians, and Filipinos), irrespective of body mass index, age, and gender. Conclusions: Clinical studieshavealready established 1,5-AG inbloodasareliablemarkerof short-term glycemic control. Our study suggests that 1,5-AG in saliva can be used in national screening programs for undiagnosed diabetes, which are of particular interest for Middle Eastern countries with young populations and exceptionally high diabetes rates.
UR - http://www.scopus.com/inward/record.url?scp=84895809667&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84895809667&partnerID=8YFLogxK
U2 - 10.1210/jc.2013-3596
DO - 10.1210/jc.2013-3596
M3 - Article
C2 - 24423354
AN - SCOPUS:84895809667
VL - 99
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 3
ER -