γ-Synuclein and the progression of cancer

Mushfika Ahmad, Samir Attoub, Maneesh N. Singh, Francis L. Martin, Omar Ali El-Agnaf

Research output: Contribution to journalReview article

59 Citations (Scopus)

Abstract

The synucleins are a small, soluble, highly conserved group of neuronal proteins that have been implicated in both neurodegenerative diseases and cancer. The synuclein family consists of α-, β-, and γ-synucleins (γ-syn). They are a natively unfolded group of proteins that share sequence homologies and structural properties (1, 2). So far, the biological functions of the synucleins are still unclear, but their involvement in neurodegenerative diseases and cancer may provide insights into the pathological processes that result from these two groups of debilitating diseases, and present the possibility to use them as potential targets for early diagnosis and treatment. Recently, elevated levels of γ-syn proteins have been detected in various types of cancer, especially in advanced stages of the disease. Furthermore, studies to date indicate that overexpression of γ-syn compromises normal mitotic checkpoint controls, resulting in multinucleation as well as faster cell growth. γ-Syn has also been shown to promote invasion and metastasis in in vitro assays as well as in animal models. Overexpression of γ-syn also interferes with drug-induced apoptotic responses. These observations raise questions about the involvement of γ-syn in the process of tumorigenesis and metastasis, and efforts have already been made to use γ-syn as a marker for assessing breast cancer progression (3). This review will discuss the involvement of γ-syn in cancer progression, metastasis and its potential as a marker.

Original languageEnglish
Pages (from-to)3419-3430
Number of pages12
JournalFASEB Journal
Volume21
Issue number13
DOIs
Publication statusPublished - Nov 2007
Externally publishedYes

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Keywords

  • Apoptosis
  • Biomarker
  • Invasion

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Ahmad, M., Attoub, S., Singh, M. N., Martin, F. L., & Ali El-Agnaf, O. (2007). γ-Synuclein and the progression of cancer. FASEB Journal, 21(13), 3419-3430. https://doi.org/10.1096/fj.07-8379rev