α-synuclein and the pathogenesis of Parkinson's disease

Francis L. Martin, Sally J.M. Williamson, Katerina E. Paleologou, David Allsop, Omar M.A. El-Agnaf

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson's disease (PD) patients. Intracellular aggregation of α-synuclein (α-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

Original languageEnglish
Pages (from-to)229-237
Number of pages9
JournalProtein and Peptide Letters
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Jun 2004

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Keywords

  • Comet assay
  • Comet tail length
  • DNA single-strand breaks
  • Environmental causation
  • Fe(II)
  • Parkinson's disease
  • Reactive oxygen species
  • α-synuclein

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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