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Research Output 2004 2019

  • 794 Citations
  • 16 h-Index
  • 21 Article
  • 1 Chapter
  • 1 Conference contribution
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Article
2019

Ursolic acid modulates MMPs, collagen-I, α-SMA, and TGF-β expression in isoproterenol-induced myocardial infarction in rats

Radhiga, T., Selvaraj, S., Sundaresan, A. & Pugalendi, K. V., 1 Jan 2019, In : Human and Experimental Toxicology.

Research output: Contribution to journalArticle

Transforming Growth Factors
Matrix Metalloproteinases
Isoproterenol
Rats
Collagen
2018
2 Citations (Scopus)

MPP+ decreases store-operated calcium entry and TRPC1 expression in Mesenchymal Stem Cell derived dopaminergic neurons

Sun, Y., Selvaraj, S., Pandey, S., Humphrey, K. M., Foster, J. D., Wu, M., Watt, J. A., Singh, B. B. & Ohm, J. E., 1 Dec 2018, In : Scientific Reports. 8, 1, 11715.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Mesenchymal Stromal Cells
Calcium
Stem Cells
1-Methyl-4-phenylpyridinium
16 Citations (Scopus)

TRPM2 promotes neurotoxin MPP+/MPTP-induced cell death

Sun, Y., Sukumaran, P., Selvaraj, S., Cilz, N. I., Schaar, A., Lei, S. & Singh, B. B., 1 Jan 2018, In : Molecular Neurobiology. 55, 1, p. 409-420 12 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Neurotoxins
Parkinson Disease
Reactive Oxygen Species
Cell Death
2017
25 Citations (Scopus)

Inhibition of L-type Ca2+ channels by TRPC1-STIM1 complex is essential for the protection of dopaminergic neurons

Sun, Y., Zhang, H., Selvaraj, S., Sukumaran, P., Lei, S., Birnbaumer, L. & Singh, B. B., 22 Mar 2017, In : Journal of Neuroscience. 37, 12, p. 3364-3377 14 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Substantia Nigra
Parkinson Disease
Neurotoxins
Caspases
2015
10 Citations (Scopus)

An Investigation of the Molecular Mechanism of Double cMyBP-C Mutation in a Patient with End-Stage Hypertrophic Cardiomyopathy

Gajendrarao, P., Krishnamoorthy, N., Selvaraj, S., Girolami, F., Cecchi, F., Olivotto, I. & Yacoub, M., 20 Jun 2015, In : Journal of Cardiovascular Translational Research. 8, 4, p. 232-243 12 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Hypertrophic Cardiomyopathy
Mutation
Phenotype
Haploinsufficiency
13 Citations (Scopus)
Cell Membrane
Endoplasmic Reticulum
Recycling
Proteins
66 Citations (Scopus)

Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway

Selvaraj, S., Sun, Y., Sukumaran, P. & Singh, B. B., 2015, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

Autophagy
Prostatic Neoplasms
Down-Regulation
Calcium
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
2013
60 Citations (Scopus)

Increase in serum Ca2+/Mg2+ ratio promotes proliferation of prostate cancer cells by activating TRPM7 channels

Sun, Y., Selvaraj, S., Varma, A., Derry, S., Sahmoun, A. E. & Singh, B. B., 4 Jan 2013, In : Journal of Biological Chemistry. 288, 1, p. 255-263 9 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Cells
Magnesium
Serum
Nucleotides
34 Citations (Scopus)

Intramolecular shielding maintains the ER Ca2+ sensor stim1 in an inactive conformation

Yu, F., Sun, L., Hubrack, S. Z., Selvaraj, S. & Machaca, K., 1 Jun 2013, In : Journal of Cell Science. 126, 11, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

Calcium
Physiological Phenomena
Cell Degranulation
Membranes
Stromal Interaction Molecule 1
28 Citations (Scopus)

In vitro antioxidant activities of Solanum surattense leaf extract

Muruhan, S., Selvaraj, S. & Viswanathan, P. K., 1 Jan 2013, In : Asian Pacific Journal of Tropical Biomedicine. 3, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

Solanum
Solanaceae
Antioxidants
Superoxides
Free Radicals
2012
16 Citations (Scopus)

Clavulanic acid inhibits MPP+-induced ROS generation and subsequent loss of dopaminergic cells

Kost, G. C., Selvaraj, S., Lee, Y. B., Kim, D. J., Ahn, C. H. & Singh, B. B., 21 Aug 2012, In : Brain Research. 1469, p. 129-135 7 p.

Research output: Contribution to journalArticle

Clavulanic Acid
Neurotoxins
1-Methyl-4-phenylpyridinium
Apoptosis
Mitochondrial Membrane Potential
36 Citations (Scopus)

Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats

Radhiga, T., Rajamanickam, C., Selvaraj, S. & Pugalendi, K. V., 1 Nov 2012, In : Food and Chemical Toxicology. 50, 11, p. 3971-3977 7 p.

Research output: Contribution to journalArticle

ursolic acid
Enzyme Assays
Isoproterenol
Rats
Assays
118 Citations (Scopus)

Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling

Selvaraj, S., Sun, Y., Watt, J. A., Wang, S., Lei, S., Birnbaumer, L. & Singh, B. B., 2 Apr 2012, In : Journal of Clinical Investigation. 122, 4, p. 1354-1367 14 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Dopaminergic Neurons
Neurotoxins
Down-Regulation
Unfolded Protein Response
2011
14 Citations (Scopus)

Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking

Kost, G. C., Selvaraj, S., Lee, Y. B., Kim, D. J., Ahn, C. H. & Singh, B. B., 24 Oct 2011, In : Neuroscience Letters. 504, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

Clavulanic Acid
Dopamine
Munc18 Proteins
Central Nervous System
Neurosecretion
2010
45 Citations (Scopus)

TRPC channels and their implications for neurological diseases

Selvaraj, S., Sun, Y. & Singh, B. B., 1 Mar 2010, In : CNS and Neurological Disorders - Drug Targets. 9, 1, p. 94-104 11 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Endoplasmic Reticulum
Cell Membrane
Neurosecretion
Physiological Phenomena
2009
57 Citations (Scopus)

TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP+

Selvaraj, S., Watt, J. A. & Singh, B. B., 1 Sep 2009, In : Cell Calcium. 46, 3, p. 209-218 10 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Neurotoxins
Mitochondrial Membrane Potential
Parkinson Disease
PC12 Cells
2007
68 Citations (Scopus)

Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in rats

Selvaraj, S., Sridevi, M. & Pugalendi, K. V., 1 Apr 2007, In : Toxicologic Pathology. 35, 3, p. 418-423 6 p.

Research output: Contribution to journalArticle

Oleanolic Acid
Isoproterenol
Myocardial Ischemia
Rats
Adenosine Triphosphatases
55 Citations (Scopus)

Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats

Selvaraj, S., Chandramohan, G. & Pugalendi, K. V., 25 Jun 2007, In : International Journal of Cardiology. 119, 1, p. 131-133 3 p.

Research output: Contribution to journalArticle

Oleanolic Acid
Isoproterenol
Myocardial Ischemia
Myocardium
Antioxidants
2006
20 Citations (Scopus)

Protective effect of ursolic acid against myocardial ischemia induced by isoproterenol in rats

Selvaraj, S., Sridevi, M. & Pugalendi, K. V., 1 Dec 2006, In : Toxicology Mechanisms and Methods. 17, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

Isoproterenol
Myocardial Ischemia
Rats
Lipid Peroxides
Lipids
2004
54 Citations (Scopus)

Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction

Selvaraj, S., Veerappan, R. M., Ramakrishna Rao, M. & Pugalendi, K. V., 1 Oct 2004, In : Clinica Chimica Acta. 348, 1-2, p. 131-137 7 p.

Research output: Contribution to journalArticle

Oxidative stress
Cardiogenic Shock
Oxidative Stress
Antioxidants
Lipid Peroxidation
27 Citations (Scopus)

Redox status and lipid peroxidation in alcoholic hypertensive patients and alcoholic hypertensive patients with diabetes

Veerappan, R. M., Selvaraj, S., Rao, M. R., Ravikumar, R. & Pugalendi, K. V., 1 Feb 2004, In : Clinica Chimica Acta. 340, 1-2, p. 207-212 6 p.

Research output: Contribution to journalArticle

Medical problems
Lipid Peroxidation
Oxidation-Reduction
Lipids
Vitamin E