• 840 Citations
  • 17 h-Index
20042019

Research output per year

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Research Output

  • 840 Citations
  • 17 h-Index
  • 20 Article
  • 1 Chapter
  • 1 Conference contribution
  • 1 Review article
2019

Ursolic acid modulates MMPs, collagen-I, α-SMA, and TGF-β expression in isoproterenol-induced myocardial infarction in rats

Radhiga, T., Selvaraj, S., Sundaresan, A. & Pugalendi, K. V., 1 Jan 2019, In : Human and Experimental Toxicology.

Research output: Contribution to journalArticle

2018

MPP+ decreases store-operated calcium entry and TRPC1 expression in Mesenchymal Stem Cell derived dopaminergic neurons

Sun, Y., Selvaraj, S., Pandey, S., Humphrey, K. M., Foster, J. D., Wu, M., Watt, J. A., Singh, B. B. & Ohm, J. E., 1 Dec 2018, In : Scientific reports. 8, 1, 11715.

Research output: Contribution to journalArticle

2 Citations (Scopus)

TRPM2 promotes neurotoxin MPP+/MPTP-induced cell death

Sun, Y., Sukumaran, P., Selvaraj, S., Cilz, N. I., Schaar, A., Lei, S. & Singh, B. B., 1 Jan 2018, In : Molecular Neurobiology. 55, 1, p. 409-420 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
2017

Inhibition of L-type Ca2+ channels by TRPC1-STIM1 complex is essential for the protection of dopaminergic neurons

Sun, Y., Zhang, H., Selvaraj, S., Sukumaran, P., Lei, S., Birnbaumer, L. & Singh, B. B., 22 Mar 2017, In : Journal of Neuroscience. 37, 12, p. 3364-3377 14 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

TRPC channels and Parkinson’s disease

Sukumaran, P., Sun, Y., Schaar, A., Selvaraj, S. & Singh, B. B., 1 Jan 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 85-94 10 p. (Advances in Experimental Medicine and Biology; vol. 976).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)
2015

An Investigation of the Molecular Mechanism of Double cMyBP-C Mutation in a Patient with End-Stage Hypertrophic Cardiomyopathy

Gajendrarao, P., Krishnamoorthy, N., Selvaraj, S., Girolami, F., Cecchi, F., Olivotto, I. & Yacoub, M., 20 Jun 2015, In : Journal of Cardiovascular Translational Research. 8, 4, p. 232-243 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca2+ influx levels

Hodeify, R., Selvaraj, S., Wen, J., Arredouani, A., Hubrack, S., Dib, M., Al-Thani, S. N., McGraw, T. & Machaca, K., 1 Aug 2015, In : Journal of Cell Science. 128, 16, p. 3143-3154 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Resveratrol activates autophagic cell death in prostate cancer cells via downregulation of STIM1 and the mTOR pathway

Selvaraj, S., Sun, Y., Sukumaran, P. & Singh, B. B., 2015, (Accepted/In press) In : Molecular Carcinogenesis.

Research output: Contribution to journalArticle

75 Citations (Scopus)
2013

Increase in serum Ca2+/Mg2+ ratio promotes proliferation of prostate cancer cells by activating TRPM7 channels

Sun, Y., Selvaraj, S., Varma, A., Derry, S., Sahmoun, A. E. & Singh, B. B., 4 Jan 2013, In : Journal of Biological Chemistry. 288, 1, p. 255-263 9 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Intramolecular shielding maintains the ER Ca2+ sensor stim1 in an inactive conformation

Yu, F., Sun, L., Hubrack, S., Selvaraj, S. & Machaca, K., 1 Jun 2013, In : Journal of Cell Science. 126, 11, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

In vitro antioxidant activities of Solanum surattense leaf extract

Muruhan, S., Selvaraj, S. & Viswanathan, P. K., Jan 2013, In : Asian Pacific Journal of Tropical Biomedicine. 3, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2012

Clavulanic acid inhibits MPP+-induced ROS generation and subsequent loss of dopaminergic cells

Kost, G. C., Selvaraj, S., Lee, Y. B., Kim, D. J., Ahn, C. H. & Singh, B. B., 21 Aug 2012, In : Brain Research. 1469, p. 129-135 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats

Radhiga, T., Rajamanickam, C., Senthil, S. & Pugalendi, K. V., 1 Nov 2012, In : Food and Chemical Toxicology. 50, 11, p. 3971-3977 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling

Selvaraj, S., Sun, Y., Watt, J. A., Wang, S., Lei, S., Birnbaumer, L. & Singh, B. B., 2 Apr 2012, In : Journal of Clinical Investigation. 122, 4, p. 1354-1367 14 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)
2011

Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking

Kost, G. C., Selvaraj, S., Lee, Y. B., Kim, D. J., Ahn, C. H. & Singh, B. B., 24 Oct 2011, In : Neuroscience Letters. 504, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Emerging roles of canonical TRP channels in neuronal function

Bollimuntha, S., Selvaraj, S. & Singh, B. B., 15 Dec 2011, Transient Receptor Potential Channels. Islam, S. & Islam, S. (eds.). p. 573-593 21 p. (Advances in Experimental Medicine and Biology; vol. 704).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

32 Citations (Scopus)
2010

TRPC channels and their implications for neurological diseases

Selvaraj, S., Sun, Y. & Singh, B. B., Mar 2010, In : CNS and Neurological Disorders - Drug Targets. 9, 1, p. 94-104 11 p.

Research output: Contribution to journalReview article

48 Citations (Scopus)
2009

TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP+

Selvaraj, S., Watt, J. A. & Singh, B. B., Sep 2009, In : Cell calcium. 46, 3, p. 209-218 10 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)
2007

Cardioprotective Effect of Oleanolic Acid on Isoproterenol-Induced Myocardial Ischemia in Rats

Senthil, S., Sridevi, M. & Pugalendi, K. V., Apr 2007, In : Toxicologic Pathology. 35, 3, p. 418-423 6 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats

Senthil, S., Chandramohan, G. & Pugalendi, K. V., 25 Jun 2007, In : International Journal of Cardiology. 119, 1, p. 131-133 3 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)
2006

Protective effect of ursolic acid against myocardial ischemia induced by isoproterenol in rats

Senthil, S., Sridevi, M. & Pugalendi, K. V., 1 Dec 2006, In : Toxicology Mechanisms and Methods. 17, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2004

Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction

Senthil, S., Veerappan, R. M., Ramakrishna Rao, M. & Pugalendi, K. V., 1 Oct 2004, In : Clinica Chimica Acta. 348, 1-2, p. 131-137 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Redox status and lipid peroxidation in alcoholic hypertensive patients and alcoholic hypertensive patients with diabetes

Veerappan, R. M., Senthil, S., Rao, M. R., Ravikumar, R. & Pugalendi, K. V., Feb 2004, In : Clinica Chimica Acta. 340, 1-2, p. 207-212 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)