• 66347 Citations
  • 132 h-Index
1969 …2020

Research output per year

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Research Output

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Review article
2019

Advances in the treatment of neuronal ceroid lipofuscinosis

Rosenberg, J. B., Chen, A., Kaminsky, S. M., Crystal, R. G. & Sondhi, D., 2 Nov 2019, In : Expert Opinion on Orphan Drugs. 7, 11, p. 473-500 28 p.

Research output: Contribution to journalReview article

2018

Biology of the Adrenal Gland Cortex Obviates Effective Use of Adeno-Associated Virus Vectors to Treat Hereditary Adrenal Disorders

Markmann, S., De, B. P., Reid, J., Jose, C. L., Rosenberg, J. B., Leopold, P. L., Kaminsky, S. M., Sondhi, D., Pagovich, O. & Crystal, R., 1 Apr 2018, In : Human Gene Therapy. 29, 4, p. 403-412 10 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Intrapleural gene therapy for alpha-1 antitrypsin deficiency-related lung disease

Stiles, K. M., Sondhi, D., Kaminsky, S. M., De, B. P., Rosenberg, J. B. & Crystal, R., 1 Jan 2018, In : Chronic Obstructive Pulmonary Diseases. 5, 4, p. 244-257 14 p.

Research output: Contribution to journalReview article

THE JEREMIAH METZGER LECTURE NOVEL THERAPEUTIC STRATEGIES OF ALLERGIC AND IMMUNOLOGIC DISORDERS

Crystal, R. & Pagovich, O. E., 1 Jan 2018, In : Transactions of the American Clinical and Climatological Association. 129, p. 250-265 16 p.

Research output: Contribution to journalReview article

2017

Genetic modification of the lung directed toward treatment of human disease

Sondhi, D., Stiles, K. M., De, B. P. & Crystal, R., 1 Jan 2017, In : Human Gene Therapy. 28, 1, p. 3-84 82 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)
2016

Gene therapy for metachromatic leukodystrophy

Rosenberg, J. B., Kaminsky, S. M., Aubourg, P., Crystal, R. & Sondhi, D., 1 Nov 2016, In : Journal of Neuroscience Research. 94, 11, p. 1169-1179 11 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)
2014

Adenovirus: The first effective in vivo gene delivery vector

Crystal, R. G., 1 Jan 2014, In : Human gene therapy. 25, 1, p. 3-11 9 p.

Research output: Contribution to journalReview article

99 Citations (Scopus)

Airway basal cells: The "smoking gun" of chronic obstructive pulmonary disease

Crystal, R., 1 Jan 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 12, p. 1355-1362 8 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)

Gene therapy: Charting a future course - Summary of a national institutes of health workshop, April 12, 2013

O'Reilly, M., Federoff, H. J., Fong, Y., Kohn, D. B., Patterson, A. P., Ahmed, N., Asokan, A., Boye, S. E., Crystal, R. G., De Oliveira, S., Gargiulo, L., Harper, S. Q., Ikeda, Y., Jambou, R., Montgomery, M., Prograis, L., Rosenthal, E., Sterman, D. H., Vandenberghe, L. H., Zoloth, L. & 15 others, Abedi, M., Adair, J., Adusumilli, P. S., Goins, W. F., Gray, J., Monahan, P., Popplewell, L., Sena-Esteves, M., Tannous, B., Weber, T., Wierda, W., Gopal-Srivastava, R., McDonald, C. L., Rosenblum, D. & Corrigan-Curay, J., 1 Jun 2014, In : Human gene therapy. 25, 6, p. 488-497 10 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)
2013

Advances in the treatment of neuronal ceroid lipofuscinosis

Sondhi, D., Rosenberg, J. B., Van De Graaf, B. G., Kaminsky, S. M. & Crystal, R. G., 1 Jan 2013, In : Expert Opinion on Orphan Drugs. 1, 12, p. 951-975 25 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Alpha-1 antitrypsin augmentation therapy

Wewers, M. D. & Crystal, R. G., 1 Mar 2013, In : COPD: Journal of Chronic Obstructive Pulmonary Disease. 10, S1, p. 64-67 4 p.

Research output: Contribution to journalReview article

24 Citations (Scopus)

Gene therapy for rare diseases: Summary of a National Institutes of Health Workshop, September 13, 2012

O'Reilly, M., Kohn, D. B., Bartlett, J., Benson, J., Brooks, P. J., Byrne, B. J., Camozzi, C., Cornetta, K., Crystal, R. G., Fong, Y., Gargiulo, L., Gopal-Srivastava, R., High, K. A., Jacobson, S. G., Jambou, R. C., Montgomery, M., Rosenthal, E., Samulski, R. J., Skarlatos, S. I., Sorrentino, B. & 3 others, Wilson, J. M., Xie, Y. & Corrigan-Curay, J., 1 Apr 2013, In : Human gene therapy. 24, 4, p. 355-362 8 p.

Research output: Contribution to journalReview article

14 Citations (Scopus)

Gene therapy to stimulate angiogenesis to treat diffuse coronary artery disease

Kaminsky, S. M., Rosengart, T. K., Rosenberg, J., Chiuchiolo, M. J., Van De Graaf, B., Sondhi, D. & Crystal, R. G., 1 Nov 2013, In : Human gene therapy. 24, 11, p. 948-963 16 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Innate immunity and chronic obstructive pulmonary disease: A mini-review

Shaykhiev, R. & Crystal, R. G., 1 Oct 2013, In : Gerontology. 59, 6, p. 481-489 9 p.

Research output: Contribution to journalReview article

41 Citations (Scopus)
2012

A call for transparent reporting to optimize the predictive value of preclinical research

Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., Finkelstein, R., Fisher, M., Gendelman, H. E., Golub, R. M., Goudreau, J. L., Gross, R. A., Gubitz, A. K., Hesterlee, S. E., Howells, D. W., Huguenard, J. & 16 others, Kelner, K., Koroshetz, W., Krainc, D., Lazic, S. E., Levine, M. S., MacLeod, M. R., McCall, J. M., Iii, R. T. M., Narasimhan, K., Noble, L. J., Perrin, S., Porter, J. D., Steward, O., Unger, E., Utz, U. & Silberberg, S. D., 11 Oct 2012, In : Nature. 490, 7419, p. 187-191 5 p.

Research output: Contribution to journalReview article

634 Citations (Scopus)

Cardiac biointerventions: Whatever happened to stem cell and gene therapy?

Rosengart, T. K., Fallon, E. & Crystal, R. G., 1 May 2012, In : Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 7, 3, p. 173-179 7 p.

Research output: Contribution to journalReview article

9 Citations (Scopus)
2009

Genetic Control of Wayward Pluripotent Stem Cells and Their Progeny after Transplantation

Kiuru, M., Boyer, J. L., O'Connor, T. P. & Crystal, R. G., 3 Apr 2009, In : Cell Stem Cell. 4, 4, p. 289-300 12 p.

Research output: Contribution to journalReview article

60 Citations (Scopus)
2008

Progress and prospects: Gene therapy for performance and appearance enhancement

Kiuru, M. & Crystal, R. G., 1 Mar 2008, In : Gene Therapy. 15, 5, p. 329-337 9 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)
2007

Human embryonic stem cells and gene therapy

Strulovici, Y., Leopold, P. L., O'Connor, T. P., Pergolizzi, R. G. & Crystal, R. G., 1 May 2007, In : Molecular Therapy. 15, 5, p. 850-866 17 p.

Research output: Contribution to journalReview article

43 Citations (Scopus)

Intracellular trafficking of adenovirus: Many means to many ends

Leopold, P. L. & Crystal, R. G., 10 Aug 2007, In : Advanced Drug Delivery Reviews. 59, 8, p. 810-821 12 p.

Research output: Contribution to journalReview article

77 Citations (Scopus)
2006

Genetic medicines: Treatment strategies for hereditary disorders

O'Connor, T. P. & Crystal, R. G., 1 Apr 2006, In : Nature Reviews Genetics. 7, 4, p. 261-276 16 p.

Research output: Contribution to journalReview article

118 Citations (Scopus)

Genetic medicine strategies to protect against bioterrorism.

Boyer, J. L. & Crystal, R. G., 2006, In : Transactions of the American Clinical and Climatological Association. 117, p. 297-310; discussion 310-311

Research output: Contribution to journalReview article

4 Citations (Scopus)
2005

Adenovirus-based genetic vaccines for biodefense

Boyer, J. L., Kobinger, G., Wilson, J. M. & Crystal, R. G., 1 Feb 2005, In : Human gene therapy. 16, 2, p. 157-168 12 p.

Research output: Contribution to journalReview article

42 Citations (Scopus)

Confronting the issues of therapeutic misconception, enrollment decisions, and personal motives in genetic medicine-based clinical research studies for fatal disorders

Arkin, L. M., Sondhi, D., Worgall, S., Suh, L. H. K., Hackett, N. R., Kaminsky, S. M., Hosain, S. A., Souweidane, M. M., Kaplitt, M. G., Dyke, J. P., Heier, L. A., Ballon, D. J., Shungu, D. C., Wisniewski, K. E., Greenwald, B. M., Hollmann, C. & Crystal, R. G., 1 Sep 2005, In : Human gene therapy. 16, 9, p. 1028-1036 9 p.

Research output: Contribution to journalReview article

27 Citations (Scopus)

Intrapleural 'outside-in' gene therapy: Therapeutics for organs of the chest via gene transfer to the pleura

Heguy, A. & Crystal, R. G., 1 Oct 2005, In : Current Opinion in Molecular Therapeutics. 7, 5, p. 440-453 14 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)
2004

Administration of a replication-deficient adeno-associated virus gene transfer vector expressing the human CLN2 cDNA to the brain of children with late infantile neuronal ceroid lipofuscinosis

Crystal, R. G., Sondhi, D., Hackett, N. R., Kaminsky, S. M., Worgall, S., Stieg, P., Souweidane, M., Hosain, S., Heier, L., Ballon, D., Dinner, M., Wisniewski, K., Kaplitt, M., Greenwald, B. M., Howell, J. D., Strybing, K., Dyke, J. & Voss, H., 1 Nov 2004, In : Human gene therapy. 15, 11, p. 1131-1154 24 p.

Research output: Contribution to journalReview article

91 Citations (Scopus)
2002

Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes

Harvey, B. G., McKinney, R. L., Rosengart, T., Lesser, M. L. & Crystal, R. G., 1 Jul 2002, In : Molecular Therapy. 6, 2, p. 287-297 11 p.

Research output: Contribution to journalReview article

46 Citations (Scopus)
2001

Feasibility of gene therapy for late neuronal ceroid lipofuscinosis

Sondhi, D., Hackett, N. R., Apblett, R. L., Kaminsky, S. M., Pergolizzi, R. G. & Crystal, R. G., 1 Jan 2001, In : Archives of Neurology. 58, 11, p. 1793-1798 6 p.

Research output: Contribution to journalReview article

Open Access
23 Citations (Scopus)
2000

Myocardial revascularization: TMR and angiogenic therapy

Rosengart, T. K., Rahman, G. F. & Crystal, R. G., 1 Dec 2000, In : Cardiovascular Reviews and Reports. 21, 8, p. 414-420 7 p.

Research output: Contribution to journalReview article

1999

Therapeutic angiogenesis: Protein and gene therapy delivery strategies

Rosengart, T. K., Patel, S. R. & Crystal, R. G., Feb 1999, In : European Journal of Preventive Cardiology. 6, 1, p. 29-40 12 p.

Research output: Contribution to journalReview article

46 Citations (Scopus)
1998

Gene therapy strategies for tumor antiangiogenesis

Kong, H. L. & Crystal, R. G., 18 Feb 1998, In : Journal of the National Cancer Institute. 90, 4, p. 273-286 14 p.

Research output: Contribution to journalReview article

165 Citations (Scopus)

Pulmonary cell biology

Mason, R. J. & Crystal, R. G., 19 May 1998, In : American Journal of Respiratory and Critical Care Medicine. 157, 4 II SUPPL., p. S72-S81

Research output: Contribution to journalReview article

15 Citations (Scopus)

Results of retroviral and adenoviral approaches to cancer gene therapy.

Yin, L. H., Fu, S. Q., Nanakorn, T., Garcia-Sanchez, F., Chung, I., Cote, R., Pizzorno, G., Hanania, E., Heimfeld, S., Crystal, R. & Deisseroth, A., 1998, In : Stem cells (Dayton, Ohio). 16 Suppl 1, p. 247-250 4 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)
1995

A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung

Crystal, R. G., Jaffe, A., Brody, S., Mastrangeli, A., McElvaney, N. G., Rosenfeld, M., Chu, C. S., Danel, C., Hay, J. & Eissa, T., 1 Jan 1995, In : Human gene therapy. 6, 5, p. 643-666 24 p.

Research output: Contribution to journalReview article

54 Citations (Scopus)
1993

Gene therapy for pulmonary diseases.

Rosenfeld, M. A., Ronald, G. & Crystal, R. G., Oct 1993, In : Pathologie-biologie. 41, 8, p. 677-680 4 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)
1992

α1-Antitrypsin augmentation therapy for chronic obstructive lung disorders

Crystal, R. G., 1 Jan 1992, In : Drugs of the Future. 17, 5, p. 387-393 7 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
1990

α1-Antitrypsin deficiency, emphysema, and liver disease: Genetic basis and strategies for therapy

Crystal, R. G., May 1990, In : Journal of Clinical Investigation. 85, 5, p. 1343-1352 10 p.

Research output: Contribution to journalReview article

Open Access
345 Citations (Scopus)
1989

Guidelines for the approach to the patient with severe hereditary alpha-1-antitrypsin deficiency

Buist, A. S., Burrows, B., Cohen, A., Crystal, R. G., Fallat, R. J., Gadek, J. E. & Turino, G. M., 1 Jan 1989, In : American Review of Respiratory Disease. 140, 5, p. 1494-1496 3 p.

Research output: Contribution to journalReview article

93 Citations (Scopus)
1984

Current concepts of the pathogenesis of fibrosis: lessons from pulmonary fibrosis.

Rennard, S. I., Bitterman, P. B. & Crystal, R. G., 1 Jan 1984, In : Progress in clinical and biological research. 154, p. 359-377 19 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Interstitial Lung Diseases of Unknown Cause: Disorders Characterized by Chronic Inflammation of the Lower Respiratory Tract

Crystal, R. G., Bitterman, P. B., Rennard, S. I., Hance, A. J. & Keogh, B. A., 19 Jan 1984, In : New England Journal of Medicine. 310, 3, p. 154-166 13 p.

Research output: Contribution to journalReview article

405 Citations (Scopus)

Interstitial Lung Diseases of Unknown Cause: Disorders Characterized by Chronic Inflammation of the Lower Respiratory Tract

Crystal, R. G., Bitterman, P. B., Rennard, S. I., Hance, A. J. & Keogh, B. A., 26 Jan 1984, In : New England Journal of Medicine. 310, 4, p. 235-244 10 p.

Research output: Contribution to journalReview article

211 Citations (Scopus)

Pathogenesis of the granulomatous lung diseases

Hunninghake, G. W., Garrett, K. C., Richerson, H. B., Fantone, J. C., Ward, P. A., Rennard, S. I., Bitterman, P. B. & Crystal, R. G., 1 Nov 1984, In : American Review of Respiratory Disease. 130, 3, p. 476-496 21 p.

Research output: Contribution to journalReview article

94 Citations (Scopus)
1983

Response of the lower respiratory tract to injury. Mechanisms of repair of the parenchymal cells of the alveolar wall

Rennard, S. I., Bitterman, P. B. & Crystal, R. G., 1 Jan 1983, In : CHEST. 84, 6, p. 735-739 5 p.

Research output: Contribution to journalReview article

23 Citations (Scopus)
1982

Alveolitis: The key to the interstitial lung disorder

Keogh, B. A. & Crystal, R. G., 1 Jan 1982, In : Thorax. 37, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

Open Access
107 Citations (Scopus)
1981

Environmental lung disease and the interstitium

Bitterman, P. B., Rennard, S. I. & Crystal, R. G., 1 Dec 1981, In : Clinics in Chest Medicine. 2, 3, p. 393-412 20 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Interstitial lung disease: Current concepts of pathogenesis, staging and therapy

Crystal, R. G., Gadek, J. E., Ferrans, V. J., Fulmer, J. D., Line, B. R. & Hunninghake, G. W., Mar 1981, In : The American Journal of Medicine. 70, 3, p. 542-568 27 p.

Research output: Contribution to journalReview article

302 Citations (Scopus)
1976

Idiopathic pulmonary fibrosis. Clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects

Crystal, R. G., Fulmer, J. D., Roberts, W. C., Moss, M. L., Line, B. R. & Reynolds, H. Y., 1 Jan 1976, In : Unknown Journal. 85, 6, p. 769-788 20 p.

Research output: Contribution to journalReview article

447 Citations (Scopus)
1975

The connective tissue of lung

Hance, A. J. & Crystal, R. G., 1 Dec 1975, In : American Review of Respiratory Disease. 112, 5, p. 657-711 55 p.

Research output: Contribution to journalReview article

147 Citations (Scopus)
1974

Lung collagen: definition, diversity and development

Crystal, R. G., 1 Dec 1974, In : Federation Proceedings. 33, 11, p. 2248-2255 8 p.

Research output: Contribution to journalReview article

26 Citations (Scopus)