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1969 …2019
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Research Output 1969 2019

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Article
2019

Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity

Wang, G., Lou, H. H., Salit, J., Leopold, P. L., Driscoll, S., Schymeinsky, J., Quast, K., Visvanathan, S., Fine, J. S., Thomas, M. J. & Crystal, R., 23 Aug 2019, In : Respiratory Research. 20, 1, 196.

Research output: Contribution to journalArticle

Open Access
Stem Cells
Cell Line
Epithelium
Air
Surface-Active Agents
1 Citation (Scopus)

Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes

Zuo, W. L., Yang, J., Strulovici-Barel, Y., Salit, J., Rostami, M., Mezey, J. G., O'Beirne, S. L., Kaner, R. J. & Crystal, R., 1 May 2019, In : The European respiratory journal. 53, 5

Research output: Contribution to journalArticle

Open Access
Bone Morphogenetic Protein 4
Stem Cells
Smoking
Phenotype
Bone Morphogenetic Protein Receptors

Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency

Matsumura, Y., Stiles, K. M., Reid, J., Frenk, E. Z., Cronin, S., Pagovich, O. E. & Crystal, R., 13 Dec 2019, In : Molecular Therapy - Methods and Clinical Development. 15, p. 72-82 11 p.

Research output: Contribution to journalArticle

Open Access
Aldehyde Dehydrogenase
Genetic Therapy
Acetaldehyde
Dependovirus
Ethanol
11 Citations (Scopus)

Gene therapy for C1 esterase inhibitor deficiency in a Murine Model of Hereditary angioedema

Qiu, T., Chiuchiolo, M. J., Whaley, A. S., Russo, A. R., Sondhi, D., Kaminsky, S. M., Crystal, R. & Pagovich, O. E., 1 Jan 2019, In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Complement C1 Inhibitor Protein
Hereditary Angioedemas
Genetic Therapy
Angioedema
Clustered Regularly Interspaced Short Palindromic Repeats

Role of KRAS in regulating normal human airway basal cell differentiation

Ogawa, F., Walters, M. S., Shafquat, A., O'Beirne, S. L., Kaner, R. J., Mezey, J. G., Zhang, H., Leopold, P. L. & Crystal, R., 9 Aug 2019, In : Respiratory Research. 20, 1, 181.

Research output: Contribution to journalArticle

Open Access
Cell Differentiation
Epithelium
Lentivirus
Epithelial Cells
Smoke
1 Citation (Scopus)

Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts

Pasquier, J., Spurgeon, M., Bradic, M., Thomas, B., Robay, A., Chidiac, O., DIb, M. J., Turjoman, R., Liberska, A., Staudt, M., Fakhro, K. A. M. A., Menzies, R., Jayyousi, A., Zirie, M., Suwaidi, J. A., Malik, R., Talal, T., Tabrizi, A. R., Mezey, J., Rodriguez-Flores, J. & 2 others, Crystal, R. & Abi Khalil, C., 1 Feb 2019, In : Epigenomics. 11, 3, p. 281-296 16 p.

Research output: Contribution to journalArticle

Diabetic Foot
Osteoclasts
Monocytes
Type 2 Diabetes Mellitus
Foot
2018
8 Citations (Scopus)

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

Rosenberg, J. B., Kaplitt, M. G., De, B. P., Chen, A., Flagiello, T., Salami, C., Pey, E., Zhao, L., Ricart Arbona, R. J., Monette, S., Dyke, J. P., Ballon, D. J., Kaminsky, S. M., Sondhi, D., Petsko, G. A., Paul, S. M. & Crystal, R., 1 Mar 2018, In : Human Gene Therapy Clinical Development. 29, 1, p. 24-47 24 p.

Research output: Contribution to journalArticle

Genetic Therapy
Alzheimer Disease
Central Nervous System
Apolipoprotein E2
Homozygote
10 Citations (Scopus)

Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes

Staudt, M. R., Salit, J., Kaner, R. J., Hollmann, C. & Crystal, R., 14 May 2018, In : Respiratory Research. 19, 1, 78.

Research output: Contribution to journalArticle

Inhalation
Lung
Nicotine
Alveolar Macrophages
Aerosols
3 Citations (Scopus)

Ambient pollution-related reprogramming of the human small airway epithelial transcriptome

O’Beirne, S. L., Shenoy, S. A., Salit, J., Strulovici-Barel, Y., Kaner, R. J., Visvanathan, S., Fine, J. S., Mezey, J. G. & Crystal, R., 1 Dec 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 11, p. 1413-1422 10 p.

Research output: Contribution to journalArticle

Transcriptome
Epithelium
Particulate Matter
Bronchoscopy
Gene Expression
2 Citations (Scopus)

Association of thrombocytosis with COPD morbidity: The SPIROMICS and COPDGene cohorts

and for the SPIROMICS and COPDGene Investigators, 26 Jan 2018, In : Respiratory Research. 19, 1, 20.

Research output: Contribution to journalArticle

Thrombocytosis
Chronic Obstructive Pulmonary Disease
Morbidity
Confidence Intervals
Odds Ratio
5 Citations (Scopus)

A systematic review on the genetics of male infertility in the era of next-generation sequencing

Robay, A., Abbasi, S., Akil, A., El-Bardisi, H., Arafa, M., Crystal, R. & Fakhro, K. A. M. A., 1 Mar 2018, In : Arab Journal of Urology. 16, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

Male Infertility
Exome
Oligospermia
Azoospermia
Technology
2 Citations (Scopus)

Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2

Markmann, S., J. Christie-Reid, J., Rosenberg, J. B., De, B. P., Kaminsky, S. M., Crystal, R. & Sondhi, D., 1 Aug 2018, In : Experimental Neurology. 306, p. 22-33 12 p.

Research output: Contribution to journalArticle

Phenotype
Dependovirus
Cholesterol
Pathology
Genes
5 Citations (Scopus)

Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia

Pagovich, O. E., Vo, M. L., Zhao, Z. Z., Petropoulos, I. N., Yuan, M., Lertsuwanroj, B., Ciralsky, J., Lai, E., Kiss, S., D'Amico, D. J., Mezey, J. G., Malik, R. & Crystal, R., 1 Dec 2018, In : Annals of Neurology. 84, 6, p. 893-904 12 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Nervous System Diseases
Confocal Microscopy
Biomarkers
Ataxia
12 Citations (Scopus)

Disease characteristics and progression in patients with late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease: an observational cohort study

Nickel, M., Simonati, A., Jacoby, D., Lezius, S., Kilian, D., Van de Graaf, B., Pagovich, O. E., Kosofsky, B., Yohay, K., Downs, M., Slasor, P., Aiayi, T., Crystal, R., Kohlschütter, A., Sondhi, D. & Schulz, A., 1 Jan 2018, (Accepted/In press) In : The Lancet Child and Adolescent Health.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Observational Studies
Disease Progression
Cohort Studies
Ceroid

Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population

O’Beirne, S. L., Salit, J., Rodriguez-Flores, J. L., Staudt, M. R., Abi Khalil, C., Fakhro, K. A. M. A., Robay, A., Ramstetter, M. D., Malek, J., Zirie, M., Jayyousi, A., Badii, R., Al-Marri, A. A. N., Bener, A., Mahmoud, M., Chiuchiolo, M. J., Al-Shakaki, A., Chidiac, O., Stadler, D., Mezey, J. G. & 1 others, Crystal, R., 1 Sep 2018, In : PLoS One. 13, 9, e0199837.

Research output: Contribution to journalArticle

Exome
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Alleles
2 Citations (Scopus)

In Vivo Potency Assay for Adeno-Associated Virus-Based Gene Therapy Vectors Using AAVrh.10 as an Example

De, B. P., Chen, A., Salami, C. O., Van De Graaf, B., Rosenberg, J. B., Pagovich, O. E., Sondhi, D., Crystal, R. & Kaminsky, S. M., 1 Jun 2018, In : Human gene therapy methods. 29, 3, p. 146-155 10 p.

Research output: Contribution to journalArticle

Dependovirus
Genetic Therapy
Transgenes
Proteins
Pharmaceutical Preparations
2 Citations (Scopus)

Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration

Zhang, H., Yang, J., Walters, M. S., Staudt, M. R., Strulovici-Barel, Y., Salit, J., Mezey, J. G., Leopold, P. L. & Crystal, R., 1 Jan 2018, In : Oncotarget. 9, 18, p. 14324-14337 14 p.

Research output: Contribution to journalArticle

Regeneration
Stem Cells
Air
Gene Expression
Chronic Obstructive Pulmonary Disease
9 Citations (Scopus)

Ontogeny and biology of human small airway epithelial club cells

Zuo, W. L., Shenoy, S. A., Li, S., O’Beirne, S. L., Strulovici-Barel, Y., Leopold, P. L., Wang, G., Staudt, M. R., Walters, M. S., Mason, C., Kaner, R. J., Mezey, J. G. & Crystal, R., 1 Dec 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 11, p. 1375-1388 14 p.

Research output: Contribution to journalArticle

Epithelial Cells
Uteroglobin
Single-Cell Analysis
Keratin-1
Epithelium
2 Citations (Scopus)

p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells

Patel, V., Singh, V. P., Pinnamaneni, J. P., Sanagasetti, D., Olive, J., Mathison, M., Cooney, A., Flores, E. R., Crystal, R., Yang, J. & Rosengart, T. K., 1 Jan 2018, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Cardiac Myocytes
Troponin T
Fibroblasts
Heart Failure
Actinin
5 Citations (Scopus)

Point-of-care whole-exome sequencing of idiopathic male infertility

Fakhro, K. A. M. A., Elbardisi, H., Arafa, M., Robay, A., Rodriguez-Flores, J. L., Al-Shakaki, A., Syed, N., Mezey, J. G., Abi Khalil, C., Malek, J., Al-Ansari, A., Al Said, S. & Crystal, R., 1 Nov 2018, In : Genetics in Medicine. 20, 11, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Exome
Male Infertility
Genes
Middle East
3 Citations (Scopus)

Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease)

Sindelar, M., Dyke, J. P., Deeb, R. S., Sondhi, D., Kaminsky, S. M., Kosofsky, B. E., Ballon, D. J., Crystal, R. & Gross, S. S., 1 Dec 2018, In : Scientific Reports. 8, 1, 15229.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Cerebrospinal Fluid
Biomarkers
Disease Progression
Lipofuscin
10 Citations (Scopus)
Exome
sequencing
Quantitative Trait Loci
loci
Metabolites
2017
2 Citations (Scopus)

An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci

Ju, J. H., Shenoy, S. A., Crystal, R. & Mezey, J. G., 1 May 2017, In : PLoS Computational Biology. 13, 5, e1005537.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Confounding
Independent component analysis
Independent Component Analysis
factor analysis
16 Citations (Scopus)

EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium

Zuo, W. L., Yang, J., Gomi, K., Chao, I. W., Crystal, R. & Shaykhiev, R., 1 Mar 2017, In : Stem Cells. 35, 3, p. 824-837 14 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Stem Cells
Epithelium
Smoking
Epidermal Growth Factor Receptor
3 Citations (Scopus)

Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling

Gomi, K., Tang, Y., Arbelaez, V., Crystal, R. & Walters, M. S., 1 Apr 2017, In : Stem Cell Reviews and Reports. 13, 2, p. 309-317 9 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Cell Differentiation
Endothelial Cells
Insulin
Stem Cells
73 Citations (Scopus)

Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

Han, M. L. K., Quibrera, P. M., Carretta, E. E., Barr, R. G., Bleecker, E. R., Bowler, R. P., Cooper, C. B., Comellas, A., Couper, D. J., Curtis, J. L., Criner, G., Dransfield, M. T., Hansel, N. N., Hoffman, E. A., Kanner, R. E., Krishnan, J. A., Martinez, C. H., Pirozzi, C. B., O'Neal, W. K., Rennard, S. & 45 others, Tashkin, D. P., Wedzicha, J. A., Woodruff, P., Paine, R., Martinez, F. J., Alexis, N. E., Anderson, W. H., Barr, R. G., Bleecker, E. R., Boucher, R. C., Bowler, R. P., Carretta, E. E., Christenson, S. A., Comellas, A. P., Cooper, C. B., Couper, D. J., Criner, G. J., Crystal, R. G., Curtis, J. L., Doerschuk, C. M., Dransfield, M. T., Freeman, C. M., Han, M. L. K., Hansel, N. N., Hastie, A. T., Hoffman, E. A., Kaner, R. J., Kanner, R. E., Kleerup, E. C., Krishnan, J. A., LaVange, L. M., Lazarus, S. C., Martinez, F. J., Meyers, D. A., Newell, J. D., Oelsner, E. C., O'Neal, W. K., Paine, R., Putcha, N., Rennard, S. I., Tashkin, D. P., Scholand, M. B., Wells, J. M., Wise, R. A. & Woodruff, P. G., 1 Aug 2017, In : The Lancet Respiratory Medicine. 5, 8, p. 619-626 8 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Cohort Studies
Outcome Assessment (Health Care)
Interleukin-15
Interleukin-8
4 Citations (Scopus)

HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype

Chung, N. P. Y., Ou, X., Khan, K. M. F., Salit, J., Kaner, R. J. & Crystal, R., 9 May 2017, In : Cell Reports. 19, 6, p. 1091-1100 10 p.

Research output: Contribution to journalArticle

Stem cells
Stem Cells
Emphysema
HIV
Tissue
11 Citations (Scopus)

In situ reprogramming to transdifferentiate fibroblasts into cardiomyocytes using adenoviral vectors: Implications for clinical myocardial regeneration

Mathison, M., Singh, V. P., Chiuchiolo, M. J., Sanagasetti, D., Mao, Y., Patel, V. B., Yang, J., Kaminsky, S. M., Crystal, R. & Rosengart, T. K., 1 Feb 2017, In : Journal of Thoracic and Cardiovascular Surgery. 153, 2, p. 329-339.e3

Research output: Contribution to journalArticle

Cardiac Myocytes
Lentivirus
Regeneration
Fibroblasts
Troponin T
36 Citations (Scopus)

Intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome: an uncontrolled phase 1/2 clinical trial

Tardieu, M., Zérah, M., Gougeon, M. L., Ausseil, J., de Bournonville, S., Husson, B., Zafeiriou, D., Parenti, G., Bourget, P., Poirier, B., Furlan, V., Artaud, C., Baugnon, T., Roujeau, T., Crystal, R., Meyer, C., Deiva, K. & Heard, J. M., 1 Sep 2017, In : The Lancet Neurology. 16, 9, p. 712-720 9 p.

Research output: Contribution to journalArticle

Mucopolysaccharidosis III
Clinical Trials, Phase I
Genetic Therapy
Acetylglucosaminidase
France
1 Citation (Scopus)

Radioiodinated Capsids Facilitate in Vivo Non-Invasive Tracking of Adeno-Associated Gene Transfer Vectors

Kothari, P., De, B. P., He, B., Chen, A., Chiuchiolo, M. J., Kim, D., Nikolopoulou, A., Amor-Coarasa, A., Dyke, J. P., Voss, H. U., Kaminsky, S. M., Foley, C. P., Vallabhajosula, S., Hu, B., DiMagno, S. G., Sondhi, D., Crystal, R., Babich, J. W. & Ballon, D., 6 Jan 2017, In : Scientific Reports. 7, 39594.

Research output: Contribution to journalArticle

Capsid
Genetic Therapy
Dependovirus
Neuronal Ceroid-Lipofuscinoses
Genes

Refining Current Scientific Priorities and Identifying New Scientific Gaps in HIV-Related Heart, Lung, Blood, and Sleep Research

Twigg, H. L., Crystal, R., Currier, J., Ridker, P., Berliner, N., Kiem, H. P., Rutherford, G., Zou, S., Glynn, S., Wong, R., Peprah, E., Engelgau, M., Creazzo, T., Colombini-Hatch, S. & Caler, E., 1 Sep 2017, In : AIDS Research and Human Retroviruses. 33, 9, p. 889-897 9 p.

Research output: Contribution to journalArticle

Sleep
National Heart, Lung, and Blood Institute (U.S.)
HIV
Lung
Research
15 Citations (Scopus)

Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium

Wang, G., Zhou, H., Strulovici-Barel, Y., Al-Hijji, M., Ou, X., Salit, J., Walters, M. S., Staudt, M. R., Kaner, R. J. & Crystal, R., 3 Jul 2017, In : Autophagy. 13, 7, p. 1205-1220 16 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Autophagy
Oxidative Stress
Epithelium
Smoking
20 Citations (Scopus)

Smoking-dependent distal-to-proximal repatterning of the adult human small airway epithelium

Yang, J., Zuo, W. L., Fukui, T., Chao, I. W., Gomi, K., Lee, B., Staudt, M. R., Kaner, R. J., Strulovici-Barel, Y., Salit, J., Crystal, R. & Shaykhiev, R., 1 Aug 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 3, p. 340-352 13 p.

Research output: Contribution to journalArticle

Epithelium
Smoking
Stem Cells
Chronic Obstructive Pulmonary Disease
Phenotype
11 Citations (Scopus)

Waterpipe smoking induces epigenetic changes in the small airway epithelium

Walters, M. S., Salit, J., Ju, J. H., Staudt, M. R., Kaner, R. J., Rogalski, A. M., Sodeinde, T. B., Rahim, R., Strulovici-Barel, Y., Mezey, J. G., Almulla, A. M., Sattar, H., Mahmoud, M. & Crystal, R., 1 Mar 2017, In : PLoS One. 12, 3, e0171112.

Research output: Contribution to journalArticle

smoking (habit)
Epigenomics
epigenetics
Tobacco Products
DNA methylation
2016
9 Citations (Scopus)

Anti-epidermal growth factor receptor gene therapy for glioblastoma

Hicks, M. J., Chiuchiolo, M. J., Ballon, D., Dyke, J. P., Aronowitz, E., Funato, K., Tabar, V., Havlicek, D., Fan, F., Sondhi, D., Kaminsky, S. M. & Crystal, R., 1 Oct 2016, In : PLoS One. 11, 10, e0162978.

Research output: Contribution to journalArticle

erbB-1 Genes
Gene therapy
gene therapy
Glioblastoma
Epidermal Growth Factor Receptor
12 Citations (Scopus)

Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy

Pagovich, O. E., Wang, B., Chiuchiolo, M. J., Kaminsky, S. M., Sondhi, D., Jose, C. L., Price, C. C., Brooks, S. F., Mezey, J. G. & Crystal, R., 1 Dec 2016, In : Journal of Allergy and Clinical Immunology. 138, 6, p. 1652-1662.e7

Research output: Contribution to journalArticle

Peanut Hypersensitivity
Anaphylaxis
Genetic Therapy
Immunoglobulin E
Arachis
4 Citations (Scopus)

Brain region-specific degeneration with disease progression in late infantile neuronal ceroid lipofuscinosis (CLN2 Disease)

Dyke, J. P., Sondhi, D., Voss, H. U., Yohay, K., Hollmann, C., Mancenido, D., Kaminsky, S. M., Heier, L. A., Rudser, K. D., Kosofsky, B., Casey, B. J., Crystal, R. & Ballon, D., 1 Jun 2016, In : American Journal of Neuroradiology. 37, 6, p. 1160-1169 10 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Disease Progression
Brain
Lysosomal Storage Diseases
Software
25 Citations (Scopus)

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD

SPIROMICS Research Group & COPDGene Investigators, 1 Aug 2016, In : PLoS Genetics. 12, 8, e1006011.

Research output: Contribution to journalArticle

Genetic Polymorphisms
Chronic Obstructive Pulmonary Disease
single nucleotide polymorphism
Single Nucleotide Polymorphism
biomarker
12 Citations (Scopus)

Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques

Evans, S. M., Foltin, R. W., Hicks, M. J., Rosenberg, J. B., De, B. P., Janda, K. D., Kaminsky, S. M. & Crystal, R., 1 Nov 2016, In : Pharmacology Biochemistry and Behavior. 150-151, p. 76-86 11 p.

Research output: Contribution to journalArticle

Self Administration
Macaca mulatta
Cocaine
Adenoviridae
Vaccines
12 Citations (Scopus)

Gene therapy for alpha-1 antitrypsin deficiency lung disease

Chiuchiolo, M. J. & Crystal, R., 1 Aug 2016, In : Annals of the American Thoracic Society. 13, p. S352-S369

Research output: Contribution to journalArticle

alpha 1-Antitrypsin Deficiency
Deficiency Diseases
alpha 1-Antitrypsin
Genetic Therapy
Lung Diseases
34 Citations (Scopus)

Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations

Rodriguez-Flores, J. L., Fakhro, K. A. M. A., Agosto-Perez, F., Ramstetter, M. D., Arbiza, L., Vincent, T. L., Robay, A., Malek, J., Suhre, K., Chouchane, L., Badii, R., Al-Marri, A. A. N., Abi Khalil, C., Zirie, M., Jayyousi, A., Salit, J., Keinan, A., Clark, A. G., Crystal, R. & Mezey, J. G., 1 Feb 2016, In : Genome Research. 26, 2, p. 151-162 12 p.

Research output: Contribution to journalArticle

Neanderthals
Genome
Population
Emigration and Immigration
Population Groups
11 Citations (Scopus)

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models

Zhao, L., Gottesdiener, A. J., Parmar, M., Li, M., Kaminsky, S. M., Chiuchiolo, M. J., Sondhi, D., Sullivan, P. M., Holtzman, D. M., Crystal, R. & Paul, S. M., 1 Aug 2016, In : Neurobiology of Aging. 44, p. 159-172 14 p.

Research output: Contribution to journalArticle

Apolipoprotein E2
Dependovirus
Amyloid
Alzheimer Disease
Pathology
7 Citations (Scopus)

JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway Epithelium

Gomi, K., Staudt, M. R., Salit, J., Kaner, R. J., Heldrich, J., Rogalski, A. M., Arbelaez, V., Crystal, R. & Walters, M. S., 1 Aug 2016, In : Stem Cell Reviews and Reports. 12, 4, p. 454-463 10 p.

Research output: Contribution to journalArticle

Cell Differentiation
Epithelium
Stem Cells
Ligands
Genes
16 Citations (Scopus)

Persistence of circulating endothelial microparticles in COPD despite smoking cessation

Strulovici-Barel, Y., Staudt, M. R., Krause, A., Gordon, C., Tilley, A. E., Harvey, B. G., Kaner, R. J., Hollmann, C., Mezey, J. G., Bitter, H., Pillai, S. G., Hilton, H., Wolff, G., Stevenson, C. S., Visvanathan, S., Fine, J. S. & Crystal, R., 1 Dec 2016, In : Thorax. 71, 12, p. 1137-1144 8 p.

Research output: Contribution to journalArticle

Smoking Cessation
Chronic Obstructive Pulmonary Disease
Lung
Apoptosis
Smoking
10 Citations (Scopus)

POU2AF1 functions in the human airway epithelium to regulate expression of host defense genes

Zhou, H., Brekman, A., Zuo, W. L., Ou, X., Shaykhiev, R., Agosto-Perez, F. J., Wang, R., Walters, M. S., Salit, J., Strulovici-Barel, Y., Staudt, M. R., Kaner, R. J., Mezey, J. G., Crystal, R. & Wang, G., 1 Apr 2016, In : Journal of Immunology. 196, 7, p. 3159-3167 9 p.

Research output: Contribution to journalArticle

Epithelium
Genes
Up-Regulation
HLA-DR alpha-Chains
Stem Cells
14 Citations (Scopus)

Pulmonary abnormalities in young, light-use waterpipe (Hookah) smokers

Strulovici-Barel, Y., Shaykhiev, R., Salit, J., Deeb, R. S., Krause, A., Kaner, R. J., Vincent, T. L., Agosto-Perez, F., Wang, G., Hollmann, C., Shanmugam, V., Almulla, A. M., Sattar, H., Mahmoud, M., Mezey, J. G., Gross, S. S., Staudt, M. R., Walters, M. S. & Crystal, R., 1 Sep 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 5, p. 587-595 9 p.

Research output: Contribution to journalArticle

Light
Lung
Smoking
Transcriptome
Metabolome
54 Citations (Scopus)

Sarcoidosis in America: Analysis based on health care use

Baughman, R. P., Field, S., Costabel, U., Crystal, R., Culver, D. A., Drent, M., Judson, M. A. & Wolff, G., 1 Jan 2016, In : Annals of the American Thoracic Society. 13, 8, p. 1244-1252 9 p.

Research output: Contribution to journalArticle

Sarcoidosis
Delivery of Health Care
African Americans
Databases
Health Care Costs
11 Citations (Scopus)

Smoking-associated disordering of the airway basal stem/progenitor cell metabotype

Deeb, R. S., Walters, M. S., Strulovici-Barel, Y., Chen, Q., Gross, S. S. & Crystal, R., 1 Feb 2016, In : American Journal of Respiratory Cell and Molecular Biology. 54, 2, p. 231-240 10 p.

Research output: Contribution to journalArticle

Stem cells
Stem Cells
Smoking
Tobacco Products
Smoke
26 Citations (Scopus)

The Qatar genome: A population-specific tool for precision medicine in the Middle East

Fakhro, K. A. M. A., Staudt, M. R., Ramstetter, M. D., Robay, A., Malek, J., Badii, R., Al-Marri, A. A. N., Abi Khalil, C., Al-Shakaki, A., Chidiac, O., Stadler, D., Zirie, M., Jayyousi, A., Salit, J., Mezey, J. G., Crystal, R. & Rodriguez-Flores, J. L., 30 Jun 2016, In : Human Genome Variation. 3, 16016.

Research output: Contribution to journalArticle

Open Access
Qatar
Precision Medicine
Middle East
Medicine
Genes
3 Citations (Scopus)

The role of interleukin-23 in the early development of emphysema in HIV1+ smokers

Barjaktarevic, I. Z., Crystal, R. & Kaner, R. J., 1 Jan 2016, In : Journal of Immunology Research. 2016, 3463104.

Research output: Contribution to journalArticle

Interleukin-23
Emphysema
Alveolar Macrophages
Matrix Metalloproteinase 9
Cytokines