• 65527 Citations
  • 132 h-Index
1969 …2019
If you made any changes in Pure these will be visible here soon.

Research Output 1969 2019

2019

Advances in the treatment of neuronal ceroid lipofuscinosis

Rosenberg, J. B., Chen, A., Kaminsky, S. M., Crystal, R. G. & Sondhi, D., 2 Nov 2019, In : Expert Opinion on Orphan Drugs. 7, 11, p. 473-500 28 p.

Research output: Contribution to journalReview article

Neuronal Ceroid-Lipofuscinoses
Therapeutics
Biomarkers
Animal Models
Enzyme Replacement Therapy

Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity

Wang, G., Lou, H. H., Salit, J., Leopold, P. L., Driscoll, S., Schymeinsky, J., Quast, K., Visvanathan, S., Fine, J. S., Thomas, M. J. & Crystal, R., 23 Aug 2019, In : Respiratory Research. 20, 1, 196.

Research output: Contribution to journalArticle

Open Access
Stem Cells
Cell Line
Epithelium
Air
Surface-Active Agents
1 Citation (Scopus)

Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes

Zuo, W. L., Yang, J., Strulovici-Barel, Y., Salit, J., Rostami, M., Mezey, J. G., O'Beirne, S. L., Kaner, R. J. & Crystal, R., 1 May 2019, In : The European respiratory journal. 53, 5

Research output: Contribution to journalArticle

Open Access
Bone Morphogenetic Protein 4
Stem Cells
Smoking
Phenotype
Bone Morphogenetic Protein Receptors

Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency

Matsumura, Y., Stiles, K. M., Reid, J., Frenk, E. Z., Cronin, S., Pagovich, O. E. & Crystal, R., 13 Dec 2019, In : Molecular Therapy - Methods and Clinical Development. 15, p. 72-82 11 p.

Research output: Contribution to journalArticle

Open Access
Aldehyde Dehydrogenase
Genetic Therapy
Acetaldehyde
Dependovirus
Ethanol
11 Citations (Scopus)

Gene therapy for C1 esterase inhibitor deficiency in a Murine Model of Hereditary angioedema

Qiu, T., Chiuchiolo, M. J., Whaley, A. S., Russo, A. R., Sondhi, D., Kaminsky, S. M., Crystal, R. & Pagovich, O. E., 1 Jan 2019, In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Complement C1 Inhibitor Protein
Hereditary Angioedemas
Genetic Therapy
Angioedema
Clustered Regularly Interspaced Short Palindromic Repeats

Role of KRAS in regulating normal human airway basal cell differentiation

Ogawa, F., Walters, M. S., Shafquat, A., O'Beirne, S. L., Kaner, R. J., Mezey, J. G., Zhang, H., Leopold, P. L. & Crystal, R., 9 Aug 2019, In : Respiratory Research. 20, 1, 181.

Research output: Contribution to journalArticle

Open Access
Cell Differentiation
Epithelium
Lentivirus
Epithelial Cells
Smoke
1 Citation (Scopus)

Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts

Pasquier, J., Spurgeon, M., Bradic, M., Thomas, B., Robay, A., Chidiac, O., DIb, M. J., Turjoman, R., Liberska, A., Staudt, M., Fakhro, K. A. M. A., Menzies, R., Jayyousi, A., Zirie, M., Suwaidi, J. A., Malik, R., Talal, T., Tabrizi, A. R., Mezey, J., Rodriguez-Flores, J. & 2 others, Crystal, R. & Abi Khalil, C., 1 Feb 2019, In : Epigenomics. 11, 3, p. 281-296 16 p.

Research output: Contribution to journalArticle

Diabetic Foot
Osteoclasts
Monocytes
Type 2 Diabetes Mellitus
Foot
2018
8 Citations (Scopus)

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease

Rosenberg, J. B., Kaplitt, M. G., De, B. P., Chen, A., Flagiello, T., Salami, C., Pey, E., Zhao, L., Ricart Arbona, R. J., Monette, S., Dyke, J. P., Ballon, D. J., Kaminsky, S. M., Sondhi, D., Petsko, G. A., Paul, S. M. & Crystal, R., 1 Mar 2018, In : Human Gene Therapy Clinical Development. 29, 1, p. 24-47 24 p.

Research output: Contribution to journalArticle

Genetic Therapy
Alzheimer Disease
Central Nervous System
Apolipoprotein E2
Homozygote
10 Citations (Scopus)

Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes

Staudt, M. R., Salit, J., Kaner, R. J., Hollmann, C. & Crystal, R., 14 May 2018, In : Respiratory Research. 19, 1, 78.

Research output: Contribution to journalArticle

Inhalation
Lung
Nicotine
Alveolar Macrophages
Aerosols
3 Citations (Scopus)

Ambient pollution-related reprogramming of the human small airway epithelial transcriptome

O’Beirne, S. L., Shenoy, S. A., Salit, J., Strulovici-Barel, Y., Kaner, R. J., Visvanathan, S., Fine, J. S., Mezey, J. G. & Crystal, R., 1 Dec 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 11, p. 1413-1422 10 p.

Research output: Contribution to journalArticle

Transcriptome
Epithelium
Particulate Matter
Bronchoscopy
Gene Expression
2 Citations (Scopus)

Association of thrombocytosis with COPD morbidity: The SPIROMICS and COPDGene cohorts

and for the SPIROMICS and COPDGene Investigators, 26 Jan 2018, In : Respiratory Research. 19, 1, 20.

Research output: Contribution to journalArticle

Thrombocytosis
Chronic Obstructive Pulmonary Disease
Morbidity
Confidence Intervals
Odds Ratio
5 Citations (Scopus)

A systematic review on the genetics of male infertility in the era of next-generation sequencing

Robay, A., Abbasi, S., Akil, A., El-Bardisi, H., Arafa, M., Crystal, R. & Fakhro, K. A. M. A., 1 Mar 2018, In : Arab Journal of Urology. 16, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

Male Infertility
Exome
Oligospermia
Azoospermia
Technology
2 Citations (Scopus)

Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2

Markmann, S., J. Christie-Reid, J., Rosenberg, J. B., De, B. P., Kaminsky, S. M., Crystal, R. & Sondhi, D., 1 Aug 2018, In : Experimental Neurology. 306, p. 22-33 12 p.

Research output: Contribution to journalArticle

Phenotype
Dependovirus
Cholesterol
Pathology
Genes
7 Citations (Scopus)

Biology of the Adrenal Gland Cortex Obviates Effective Use of Adeno-Associated Virus Vectors to Treat Hereditary Adrenal Disorders

Markmann, S., De, B. P., Reid, J., Jose, C. L., Rosenberg, J. B., Leopold, P. L., Kaminsky, S. M., Sondhi, D., Pagovich, O. & Crystal, R., 1 Apr 2018, In : Human Gene Therapy. 29, 4, p. 403-412 10 p.

Research output: Contribution to journalReview article

Congenital Adrenal Hyperplasia
Dependovirus
Adrenal Cortex
Adrenal Glands
Steroid 21-Hydroxylase
5 Citations (Scopus)

Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia

Pagovich, O. E., Vo, M. L., Zhao, Z. Z., Petropoulos, I. N., Yuan, M., Lertsuwanroj, B., Ciralsky, J., Lai, E., Kiss, S., D'Amico, D. J., Mezey, J. G., Malik, R. & Crystal, R., 1 Dec 2018, In : Annals of Neurology. 84, 6, p. 893-904 12 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Nervous System Diseases
Confocal Microscopy
Biomarkers
Ataxia
12 Citations (Scopus)

Disease characteristics and progression in patients with late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease: an observational cohort study

Nickel, M., Simonati, A., Jacoby, D., Lezius, S., Kilian, D., Van de Graaf, B., Pagovich, O. E., Kosofsky, B., Yohay, K., Downs, M., Slasor, P., Aiayi, T., Crystal, R., Kohlschütter, A., Sondhi, D. & Schulz, A., 1 Jan 2018, (Accepted/In press) In : The Lancet Child and Adolescent Health.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Observational Studies
Disease Progression
Cohort Studies
Ceroid

Enzyme linked immunoassay (elisa) for connective tissue proteins: Type 1 collagen

Rennard, S. I., Martin, G. R. & Crystal, R., 1 Jan 2018, Immunochemistry of the Extracellular Matrix: Volume 1: Methods. CRC Press, p. 237-252 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Collagen Type I
Immunoenzyme Techniques
Connective Tissue
Collagen
Tissue

Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population

O’Beirne, S. L., Salit, J., Rodriguez-Flores, J. L., Staudt, M. R., Abi Khalil, C., Fakhro, K. A. M. A., Robay, A., Ramstetter, M. D., Malek, J., Zirie, M., Jayyousi, A., Badii, R., Al-Marri, A. A. N., Bener, A., Mahmoud, M., Chiuchiolo, M. J., Al-Shakaki, A., Chidiac, O., Stadler, D., Mezey, J. G. & 1 others, Crystal, R., 1 Sep 2018, In : PLoS One. 13, 9, e0199837.

Research output: Contribution to journalArticle

Exome
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Alleles

Intrapleural gene therapy for alpha-1 antitrypsin deficiency-related lung disease

Stiles, K. M., Sondhi, D., Kaminsky, S. M., De, B. P., Rosenberg, J. B. & Crystal, R., 1 Jan 2018, In : Chronic Obstructive Pulmonary Diseases. 5, 4, p. 244-257 14 p.

Research output: Contribution to journalReview article

alpha 1-Antitrypsin Deficiency
alpha 1-Antitrypsin
Genetic Therapy
Lung Diseases
Leukocyte Elastase
2 Citations (Scopus)

In Vivo Potency Assay for Adeno-Associated Virus-Based Gene Therapy Vectors Using AAVrh.10 as an Example

De, B. P., Chen, A., Salami, C. O., Van De Graaf, B., Rosenberg, J. B., Pagovich, O. E., Sondhi, D., Crystal, R. & Kaminsky, S. M., 1 Jun 2018, In : Human gene therapy methods. 29, 3, p. 146-155 10 p.

Research output: Contribution to journalArticle

Dependovirus
Genetic Therapy
Transgenes
Proteins
Pharmaceutical Preparations
2 Citations (Scopus)

Mandatory role of HMGA1 in human airway epithelial normal differentiation and post-injury regeneration

Zhang, H., Yang, J., Walters, M. S., Staudt, M. R., Strulovici-Barel, Y., Salit, J., Mezey, J. G., Leopold, P. L. & Crystal, R., 1 Jan 2018, In : Oncotarget. 9, 18, p. 14324-14337 14 p.

Research output: Contribution to journalArticle

Regeneration
Stem Cells
Air
Gene Expression
Chronic Obstructive Pulmonary Disease
9 Citations (Scopus)

Ontogeny and biology of human small airway epithelial club cells

Zuo, W. L., Shenoy, S. A., Li, S., O’Beirne, S. L., Strulovici-Barel, Y., Leopold, P. L., Wang, G., Staudt, M. R., Walters, M. S., Mason, C., Kaner, R. J., Mezey, J. G. & Crystal, R., 1 Dec 2018, In : American Journal of Respiratory and Critical Care Medicine. 198, 11, p. 1375-1388 14 p.

Research output: Contribution to journalArticle

Epithelial Cells
Uteroglobin
Single-Cell Analysis
Keratin-1
Epithelium
2 Citations (Scopus)

p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells

Patel, V., Singh, V. P., Pinnamaneni, J. P., Sanagasetti, D., Olive, J., Mathison, M., Cooney, A., Flores, E. R., Crystal, R., Yang, J. & Rosengart, T. K., 1 Jan 2018, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Cardiac Myocytes
Troponin T
Fibroblasts
Heart Failure
Actinin
5 Citations (Scopus)

Point-of-care whole-exome sequencing of idiopathic male infertility

Fakhro, K. A. M. A., Elbardisi, H., Arafa, M., Robay, A., Rodriguez-Flores, J. L., Al-Shakaki, A., Syed, N., Mezey, J. G., Abi Khalil, C., Malek, J., Al-Ansari, A., Al Said, S. & Crystal, R., 1 Nov 2018, In : Genetics in Medicine. 20, 11, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Exome
Male Infertility
Genes
Middle East

THE JEREMIAH METZGER LECTURE NOVEL THERAPEUTIC STRATEGIES OF ALLERGIC AND IMMUNOLOGIC DISORDERS

Crystal, R. & Pagovich, O. E., 1 Jan 2018, In : Transactions of the American Clinical and Climatological Association. 129, p. 250-265 16 p.

Research output: Contribution to journalReview article

Genetic Therapy
Peanut Hypersensitivity
Hereditary Angioedemas
Immune System Diseases
Monoclonal Antibodies
3 Citations (Scopus)

Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease)

Sindelar, M., Dyke, J. P., Deeb, R. S., Sondhi, D., Kaminsky, S. M., Kosofsky, B. E., Ballon, D. J., Crystal, R. & Gross, S. S., 1 Dec 2018, In : Scientific Reports. 8, 1, 15229.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Cerebrospinal Fluid
Biomarkers
Disease Progression
Lipofuscin
10 Citations (Scopus)
Exome
sequencing
Quantitative Trait Loci
loci
Metabolites
2017
2 Citations (Scopus)

An independent component analysis confounding factor correction framework for identifying broad impact expression quantitative trait loci

Ju, J. H., Shenoy, S. A., Crystal, R. & Mezey, J. G., 1 May 2017, In : PLoS Computational Biology. 13, 5, e1005537.

Research output: Contribution to journalArticle

Quantitative Trait Loci
Confounding
Independent component analysis
Independent Component Analysis
factor analysis
1 Citation (Scopus)
16 Citations (Scopus)

EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium

Zuo, W. L., Yang, J., Gomi, K., Chao, I. W., Crystal, R. & Shaykhiev, R., 1 Mar 2017, In : Stem Cells. 35, 3, p. 824-837 14 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Stem Cells
Epithelium
Smoking
Epidermal Growth Factor Receptor
3 Citations (Scopus)

Endothelial Cell Mediated Promotion of Ciliated Cell Differentiation of Human Airway Basal Cells via Insulin and Insulin-Like Growth Factor 1 Receptor Mediated Signaling

Gomi, K., Tang, Y., Arbelaez, V., Crystal, R. & Walters, M. S., 1 Apr 2017, In : Stem Cell Reviews and Reports. 13, 2, p. 309-317 9 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Cell Differentiation
Endothelial Cells
Insulin
Stem Cells
73 Citations (Scopus)

Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

Han, M. L. K., Quibrera, P. M., Carretta, E. E., Barr, R. G., Bleecker, E. R., Bowler, R. P., Cooper, C. B., Comellas, A., Couper, D. J., Curtis, J. L., Criner, G., Dransfield, M. T., Hansel, N. N., Hoffman, E. A., Kanner, R. E., Krishnan, J. A., Martinez, C. H., Pirozzi, C. B., O'Neal, W. K., Rennard, S. & 45 others, Tashkin, D. P., Wedzicha, J. A., Woodruff, P., Paine, R., Martinez, F. J., Alexis, N. E., Anderson, W. H., Barr, R. G., Bleecker, E. R., Boucher, R. C., Bowler, R. P., Carretta, E. E., Christenson, S. A., Comellas, A. P., Cooper, C. B., Couper, D. J., Criner, G. J., Crystal, R. G., Curtis, J. L., Doerschuk, C. M., Dransfield, M. T., Freeman, C. M., Han, M. L. K., Hansel, N. N., Hastie, A. T., Hoffman, E. A., Kaner, R. J., Kanner, R. E., Kleerup, E. C., Krishnan, J. A., LaVange, L. M., Lazarus, S. C., Martinez, F. J., Meyers, D. A., Newell, J. D., Oelsner, E. C., O'Neal, W. K., Paine, R., Putcha, N., Rennard, S. I., Tashkin, D. P., Scholand, M. B., Wells, J. M., Wise, R. A. & Woodruff, P. G., 1 Aug 2017, In : The Lancet Respiratory Medicine. 5, 8, p. 619-626 8 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Cohort Studies
Outcome Assessment (Health Care)
Interleukin-15
Interleukin-8
10 Citations (Scopus)

Genetic modification of the lung directed toward treatment of human disease

Sondhi, D., Stiles, K. M., De, B. P. & Crystal, R., 1 Jan 2017, In : Human Gene Therapy. 28, 1, p. 3-84 82 p.

Research output: Contribution to journalReview article

Lung
Therapeutics
Architectural Accessibility
Inborn Genetic Diseases
Respiratory Syncytial Viruses
4 Citations (Scopus)

HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype

Chung, N. P. Y., Ou, X., Khan, K. M. F., Salit, J., Kaner, R. J. & Crystal, R., 9 May 2017, In : Cell Reports. 19, 6, p. 1091-1100 10 p.

Research output: Contribution to journalArticle

Stem cells
Stem Cells
Emphysema
HIV
Tissue
11 Citations (Scopus)

In situ reprogramming to transdifferentiate fibroblasts into cardiomyocytes using adenoviral vectors: Implications for clinical myocardial regeneration

Mathison, M., Singh, V. P., Chiuchiolo, M. J., Sanagasetti, D., Mao, Y., Patel, V. B., Yang, J., Kaminsky, S. M., Crystal, R. & Rosengart, T. K., 1 Feb 2017, In : Journal of Thoracic and Cardiovascular Surgery. 153, 2, p. 329-339.e3

Research output: Contribution to journalArticle

Cardiac Myocytes
Lentivirus
Regeneration
Fibroblasts
Troponin T
36 Citations (Scopus)

Intracerebral gene therapy in children with mucopolysaccharidosis type IIIB syndrome: an uncontrolled phase 1/2 clinical trial

Tardieu, M., Zérah, M., Gougeon, M. L., Ausseil, J., de Bournonville, S., Husson, B., Zafeiriou, D., Parenti, G., Bourget, P., Poirier, B., Furlan, V., Artaud, C., Baugnon, T., Roujeau, T., Crystal, R., Meyer, C., Deiva, K. & Heard, J. M., 1 Sep 2017, In : The Lancet Neurology. 16, 9, p. 712-720 9 p.

Research output: Contribution to journalArticle

Mucopolysaccharidosis III
Clinical Trials, Phase I
Genetic Therapy
Acetylglucosaminidase
France
1 Citation (Scopus)

Radioiodinated Capsids Facilitate in Vivo Non-Invasive Tracking of Adeno-Associated Gene Transfer Vectors

Kothari, P., De, B. P., He, B., Chen, A., Chiuchiolo, M. J., Kim, D., Nikolopoulou, A., Amor-Coarasa, A., Dyke, J. P., Voss, H. U., Kaminsky, S. M., Foley, C. P., Vallabhajosula, S., Hu, B., DiMagno, S. G., Sondhi, D., Crystal, R., Babich, J. W. & Ballon, D., 6 Jan 2017, In : Scientific Reports. 7, 39594.

Research output: Contribution to journalArticle

Capsid
Genetic Therapy
Dependovirus
Neuronal Ceroid-Lipofuscinoses
Genes

Refining Current Scientific Priorities and Identifying New Scientific Gaps in HIV-Related Heart, Lung, Blood, and Sleep Research

Twigg, H. L., Crystal, R., Currier, J., Ridker, P., Berliner, N., Kiem, H. P., Rutherford, G., Zou, S., Glynn, S., Wong, R., Peprah, E., Engelgau, M., Creazzo, T., Colombini-Hatch, S. & Caler, E., 1 Sep 2017, In : AIDS Research and Human Retroviruses. 33, 9, p. 889-897 9 p.

Research output: Contribution to journalArticle

Sleep
National Heart, Lung, and Blood Institute (U.S.)
HIV
Lung
Research
15 Citations (Scopus)

Role of OSGIN1 in mediating smoking-induced autophagy in the human airway epithelium

Wang, G., Zhou, H., Strulovici-Barel, Y., Al-Hijji, M., Ou, X., Salit, J., Walters, M. S., Staudt, M. R., Kaner, R. J. & Crystal, R., 3 Jul 2017, In : Autophagy. 13, 7, p. 1205-1220 16 p.

Research output: Contribution to journalArticle

Growth Inhibitors
Autophagy
Oxidative Stress
Epithelium
Smoking
20 Citations (Scopus)

Smoking-dependent distal-to-proximal repatterning of the adult human small airway epithelium

Yang, J., Zuo, W. L., Fukui, T., Chao, I. W., Gomi, K., Lee, B., Staudt, M. R., Kaner, R. J., Strulovici-Barel, Y., Salit, J., Crystal, R. & Shaykhiev, R., 1 Aug 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 3, p. 340-352 13 p.

Research output: Contribution to journalArticle

Epithelium
Smoking
Stem Cells
Chronic Obstructive Pulmonary Disease
Phenotype
11 Citations (Scopus)

Waterpipe smoking induces epigenetic changes in the small airway epithelium

Walters, M. S., Salit, J., Ju, J. H., Staudt, M. R., Kaner, R. J., Rogalski, A. M., Sodeinde, T. B., Rahim, R., Strulovici-Barel, Y., Mezey, J. G., Almulla, A. M., Sattar, H., Mahmoud, M. & Crystal, R., 1 Mar 2017, In : PLoS One. 12, 3, e0171112.

Research output: Contribution to journalArticle

smoking (habit)
Epigenomics
epigenetics
Tobacco Products
DNA methylation
2016
9 Citations (Scopus)

Anti-epidermal growth factor receptor gene therapy for glioblastoma

Hicks, M. J., Chiuchiolo, M. J., Ballon, D., Dyke, J. P., Aronowitz, E., Funato, K., Tabar, V., Havlicek, D., Fan, F., Sondhi, D., Kaminsky, S. M. & Crystal, R., 1 Oct 2016, In : PLoS One. 11, 10, e0162978.

Research output: Contribution to journalArticle

erbB-1 Genes
Gene therapy
gene therapy
Glioblastoma
Epidermal Growth Factor Receptor
12 Citations (Scopus)

Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy

Pagovich, O. E., Wang, B., Chiuchiolo, M. J., Kaminsky, S. M., Sondhi, D., Jose, C. L., Price, C. C., Brooks, S. F., Mezey, J. G. & Crystal, R., 1 Dec 2016, In : Journal of Allergy and Clinical Immunology. 138, 6, p. 1652-1662.e7

Research output: Contribution to journalArticle

Peanut Hypersensitivity
Anaphylaxis
Genetic Therapy
Immunoglobulin E
Arachis
4 Citations (Scopus)

Brain region-specific degeneration with disease progression in late infantile neuronal ceroid lipofuscinosis (CLN2 Disease)

Dyke, J. P., Sondhi, D., Voss, H. U., Yohay, K., Hollmann, C., Mancenido, D., Kaminsky, S. M., Heier, L. A., Rudser, K. D., Kosofsky, B., Casey, B. J., Crystal, R. & Ballon, D., 1 Jun 2016, In : American Journal of Neuroradiology. 37, 6, p. 1160-1169 10 p.

Research output: Contribution to journalArticle

Neuronal Ceroid-Lipofuscinoses
Disease Progression
Brain
Lysosomal Storage Diseases
Software
3 Citations (Scopus)

Cigarette smoking induces changes in airway epithelial expression of genes associated with monogenic lung disorders

Tilley, A. E., Staudt, M. R., Salit, J., Van De Graaf, B., Strulovici-Barel, Y., Kaner, R. J., Vincent, T., Agosto-Perez, F., Mezey, J. G., Raby, B. A. & Crystal, R., 15 Jan 2016, In : American Journal of Respiratory and Critical Care Medicine. 193, 2, p. 215-217 3 p.

Research output: Contribution to journalLetter

Lung Diseases
Respiration
Smoking
Phenotype
Gene Expression
25 Citations (Scopus)

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD

SPIROMICS Research Group & COPDGene Investigators, 1 Aug 2016, In : PLoS Genetics. 12, 8, e1006011.

Research output: Contribution to journalArticle

Genetic Polymorphisms
Chronic Obstructive Pulmonary Disease
single nucleotide polymorphism
Single Nucleotide Polymorphism
biomarker

Correction: Type 2 diabetes risk allele loci in the Qatari population (PLoS ONE (2016) 11:7 (e0156834) DOI: 10.1371/journal.pone.0156834)

O'Beirne, S. L., Salit, J., Rodriguez-Flores, J. L., Staudt, M. R., Khalil, C. A., Fakhro, K. A., Robay, A., Ramstetter, M. D., Al-Azwani, I. K., Malek, J. A., Zirie, M., Jayyousi, A., Badii, R., Al-Marri, A. A. N., Chiuchiolo, M. J., Al-Shakaki, A., Chidiac, O., Gharbiah, M., Bener, A., Stadler, D. & 3 others, Hackett, N. R., Mezey, J. G. & Crystal, R. G., 1 Aug 2016, In : PLoS One. 11, 8, e0161910.

Research output: Contribution to journalComment/debate

e-mail
Electronic mail
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
12 Citations (Scopus)

Efficacy of an adenovirus-based anti-cocaine vaccine to reduce cocaine self-administration and reacqusition using a choice procedure in rhesus macaques

Evans, S. M., Foltin, R. W., Hicks, M. J., Rosenberg, J. B., De, B. P., Janda, K. D., Kaminsky, S. M. & Crystal, R., 1 Nov 2016, In : Pharmacology Biochemistry and Behavior. 150-151, p. 76-86 11 p.

Research output: Contribution to journalArticle

Self Administration
Macaca mulatta
Cocaine
Adenoviridae
Vaccines
2 Citations (Scopus)

From the authors

Harvey, B. G., Strulovici-Barel, Y., Kaner, R. J., Sanders, A., Vincent, T. L., Mezey, J. G. & Crystal, R., 1 Jun 2016, In : European Respiratory Journal. 47, 6, p. 1888-1889 2 p.

Research output: Contribution to journalLetter

12 Citations (Scopus)

Gene therapy for alpha-1 antitrypsin deficiency lung disease

Chiuchiolo, M. J. & Crystal, R., 1 Aug 2016, In : Annals of the American Thoracic Society. 13, p. S352-S369

Research output: Contribution to journalArticle

alpha 1-Antitrypsin Deficiency
Deficiency Diseases
alpha 1-Antitrypsin
Genetic Therapy
Lung Diseases