• 219 Citations
  • 10 h-Index
20082019

Research output per year

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Research Output

  • 219 Citations
  • 10 h-Index
  • 17 Article
  • 1 Review article
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Article
2019

Next generation sequencing and animal models reveal SLC9A3R1 as a new gene involved in human age-related hearing loss

Girotto, G., Morgan, A., Krishnamoorthy, N., Cocca, M., Brumat, M., Bassani, S., Bianca, M. L., Di Stazio, M. & Gasparini, P., 1 Jan 2019, In : Frontiers in Genetics. 10, FEB, 142.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Next-generation sequencing identified SPATC1L as a possible candidate gene for both early-onset and age-related hearing loss

Morgan, A., Vuckovic, D., Krishnamoorthy, N., Rubinato, E., Ambrosetti, U., Castorina, P., Franzè, A., Vozzi, D., La Bianca, M., Cappellani, S., Di Stazio, M., Gasparini, P. & Girotto, G., 1 Jan 2019, In : European Journal of Human Genetics. 27, 1, p. 70-79 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2018

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction

Da’as, S. I., Fakhro, K., Thanassoulas, A., Krishnamoorthy, N., Saleh, A., Calver, B. L., Safieh-Garabedian, B., Toft, E., Nounesis, G., Anthony Lai, F. & Nomikos, M., 14 Dec 2018, In : Biochemical Journal. 475, 24, p. 3933-3948 16 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies

Ismail, H. M., Krishnamoorthy, N., Al-Dewik, N., Zayed, H., Mohamed, N. A., Giacomo, V. D., Gupta, S., Häberle, J., Thöny, B., Blom, H. J., Kruger, W. D., Ben-Omran, T. & Nasrallah, G. K., 1 Jan 2018, (Accepted/In press) In : Human Mutation.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2017

Impact of disease-causing mutations on inter-domain interactions in cMyBP-C: a steered molecular dynamics study

Krishnamoorthy, N., Gajendrarao, P., Olivotto, I. & Yacoub, M., 4 Jul 2017, In : Journal of Biomolecular Structure and Dynamics. 35, 9, p. 1916-1922 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Targeted sequencing identifies novel variants involved in autosomal recessive hereditary hearing loss in Qatari families

Al-Kowari, M. K., Vozzi, D., Bhagat, S., Krishnamoorthy, N., Morgan, A., Hayder, Y., Logendra, B. W., Najjar, N., Gandin, I., Gasparini, P., Badii, R., Girotto, G. & Abdulhadi, K., 1 Aug 2017, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 800-802, p. 29-36 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Two patients with Canavan disease and structural modeling of a novel mutation

Zaki, O. K., Krishnamoorthy, N., El Abd, H. S., Harche, S. A., Mattar, R. A., Al disi, R. S., Nofal, M. Y., El Bekay, R., Ahmed, K. A., George Priya Doss, C. & Zayed, H., 1 Feb 2017, In : Metabolic Brain Disease. 32, 1, p. 171-177 7 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2016

Structural modeling of p.V31F variant in the aspartoacylase gene

Krishnamoorthy, N. & Zayed, H., 21 Jan 2016, (Accepted/In press) In : Metabolic Brain Disease. p. 1-4 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2015

An Investigation of the Molecular Mechanism of Double cMyBP-C Mutation in a Patient with End-Stage Hypertrophic Cardiomyopathy

Gajendrarao, P., Krishnamoorthy, N., Selvaraj, S., Girolami, F., Cecchi, F., Olivotto, I. & Yacoub, M., 20 Jun 2015, In : Journal of Cardiovascular Translational Research. 8, 4, p. 232-243 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2013

Molecular Modeling of Disease Causing Mutations in Domain C1 of cMyBP-C

Gajendrarao, P., Krishnamoorthy, N., Kassem, H. S., Moharem-Elgamal, S., Cecchi, F., Olivotto, I. & Yacoub, M. H., 19 Mar 2013, In : PloS one. 8, 3, e59206.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2011

A computational modeling approach for enhancing self-assembly and biofunctionalisation of collagen biomimetic peptides

Krishnamoorthy, N., Yacoub, M. H. & Yaliraki, S. N., 1 Oct 2011, In : Biomaterials. 32, 30, p. 7275-7285 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2010

Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site

Gajendrarao, P., Krishnamoorthy, N., Sakkiah, S., Lazar, P. & Lee, K. W., 26 Feb 2010, In : Journal of Molecular Graphics and Modelling. 28, 6, p. 524-532 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Pharmacophore modeling, virtual screening and molecular docking studies for identification of new inverse agonists of human histamine H1 receptor

Thangapandian, S., Krishnamoorthy, N., John, S., Sakkiah, S., Lazar, P., Lee, Y. & Lee, K. W., 1 Jan 2010, In : Bulletin of the Korean Chemical Society. 31, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Probing possible egress channels for multiple ligands in human CYP3A4: A molecular modeling study

Krishnamoorthy, N., Gajendrarao, P., Thangapandian, S., Lee, Y. & Lee, K. W., 1 Jan 2010, In : Journal of Molecular Modeling. 16, 4, p. 607-614 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2009

Pharmacophore mapping and virtual screening for SIRT1 activators

Sakkiah, S., Krishnamoorthy, N., Gajendrarao, P., Thangapandian, S., Lee, Y., Kim, S., Suh, J. K., Kim, H. H. & Lee, K. W., 13 Oct 2009, In : Bulletin of the Korean Chemical Society. 30, 5, p. 1152-1156 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The CYP3A4*18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density

Kang, Y. S., Park, S. Y., Yim, C. H., Kwak, H. S., Gajendrarao, P., Krishnamoorthy, N., Yun, S. C., Lee, K. W. & Han, K. O., 1 Mar 2009, In : Clinical Pharmacology and Therapeutics. 85, 3, p. 312-318 7 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
2008

Molecular modeling study of CodX reveals importance of N-terminal and C-terminal domain in the CodWX complex structure of Bacillus subtilis

Krishnamoorthy, N., Gajendrarao, P., Eom, S. H., Kwon, Y. J., Cheong, G. W. & Lee, K. W., 1 Aug 2008, In : Journal of Molecular Graphics and Modelling. 27, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)