• 207 Citations
  • 9 h-Index
20082019
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Research Output 2008 2019

  • 207 Citations
  • 9 h-Index
  • 17 Article
  • 1 Review article
23 Citations (Scopus)

A computational modeling approach for enhancing self-assembly and biofunctionalisation of collagen biomimetic peptides

Krishnamoorthy, N., Yacoub, M. H. & Yaliraki, S. N., 1 Oct 2011, In : Biomaterials. 32, 30, p. 7275-7285 11 p.

Research output: Contribution to journalArticle

Biomimetics
Collagen
Self assembly
Peptides
Tropocollagen
11 Citations (Scopus)

An Investigation of the Molecular Mechanism of Double cMyBP-C Mutation in a Patient with End-Stage Hypertrophic Cardiomyopathy

Gajendrarao, P., Krishnamoorthy, N., Selvaraj, S., Girolami, F., Cecchi, F., Olivotto, I. & Yacoub, M., 20 Jun 2015, In : Journal of Cardiovascular Translational Research. 8, 4, p. 232-243 12 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Hypertrophic Cardiomyopathy
Mutation
Phenotype
Haploinsufficiency
1 Citation (Scopus)

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction

Da'as, S., Fakhro, K. A. M. A., Thanassoulas, A., Krishnamoorthy, N., Saleh, A., Calver, B. L., Safieh-Garabedian, B., Toft, E., Nounesis, G., Anthony Lai, F. & Nomikos, M., 14 Dec 2018, In : Biochemical Journal. 475, 24, p. 3933-3948 16 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Hypertrophic Cardiomyopathy
Actins
Carrier Proteins
Display devices
12 Citations (Scopus)

Impact of disease-causing mutations on inter-domain interactions in cMyBP-C: a steered molecular dynamics study

Krishnamoorthy, N., Gajendrarao, P., Olivotto, I. & Yacoub, M., 4 Jul 2017, In : Journal of Biomolecular Structure and Dynamics. 35, 9, p. 1916-1922 7 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Molecular Dynamics Simulation
Mutation
Hypertrophic Cardiomyopathy
Muscle Contraction
1 Citation (Scopus)

In silico and in vivo models for Qatari-specific classical homocystinuria as basis for development of novel therapies

Ismail, H. M., Krishnamoorthy, N., Al-Dewik, N., Zayed, H., Mohamed, N. A., Giacomo, V. D., Gupta, S., Häberle, J., Thöny, B., Blom, H. J., Kruger, W. D., Ben-Omran, T. & Nasrallah, G. K., 1 Jan 2018, (Accepted/In press) In : Human Mutation.

Research output: Contribution to journalArticle

Cystathionine
Homocystinuria
Computer Simulation
Therapeutics
Yeasts
15 Citations (Scopus)

Molecular Modeling of Disease Causing Mutations in Domain C1 of cMyBP-C

Gajendrarao, P., Krishnamoorthy, N., Kassem, H. S., Moharem-Elgamal, S., Cecchi, F., Olivotto, I. & Yacoub, M. H., 19 Mar 2013, In : PLoS One. 8, 3, e59206.

Research output: Contribution to journalArticle

Cardiac Myosins
Molecular modeling
myosin
binding proteins
mutation
1 Citation (Scopus)

Molecular modeling study of CodX reveals importance of N-terminal and C-terminal domain in the CodWX complex structure of Bacillus subtilis

Krishnamoorthy, N., Gajendrarao, P., Eom, S. H., Kwon, Y. J., Cheong, G. W. & Lee, K. W., 1 Aug 2008, In : Journal of Molecular Graphics and Modelling. 27, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Proteolysis
Molecular modeling
Bacillus
Bacilli
Adenosine Triphosphatases
12 Citations (Scopus)

Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site

Gajendrarao, P., Krishnamoorthy, N., Sakkiah, S., Lazar, P. & Lee, K. W., 26 Feb 2010, In : Journal of Molecular Graphics and Modelling. 28, 6, p. 524-532 9 p.

Research output: Contribution to journalArticle

Molecular modeling
cytochromes
Binding sites
Cytochrome P-450 Enzyme System
Binding Sites

Next generation sequencing and animal models reveal SLC9A3R1 as a new gene involved in human age-related hearing loss

Girotto, G., Morgan, A., Krishnamoorthy, N., Cocca, M., Brumat, M., Bassani, S., Bianca, M. L., Di Stazio, M. & Gasparini, P., 1 Jan 2019, In : Frontiers in Genetics. 10, FEB, 142.

Research output: Contribution to journalArticle

Open Access
Hearing Loss
Animal Models
Otolithic Membrane
Zebrafish
Genes
3 Citations (Scopus)

Next-generation sequencing identified SPATC1L as a possible candidate gene for both early-onset and age-related hearing loss

Morgan, A., Vuckovic, D., Krishnamoorthy, N., Rubinato, E., Ambrosetti, U., Castorina, P., Franzè, A., Vozzi, D., La Bianca, M., Cappellani, S., Di Stazio, M., Gasparini, P. & Girotto, G., 1 Jan 2018, (Accepted/In press) In : European Journal of Human Genetics.

Research output: Contribution to journalArticle

Hearing Loss
Age of Onset
Genes
Hearing
Central Asia
21 Citations (Scopus)

Pharmacophore mapping and virtual screening for SIRT1 activators

Sakkiah, S., Krishnamoorthy, N., Gajendrarao, P., Thangapandian, S., Lee, Y., Kim, S., Suh, J. K., Kim, H. H. & Lee, K. W., 13 Oct 2009, In : Bulletin of the Korean Chemical Society. 30, 5, p. 1152-1156 5 p.

Research output: Contribution to journalArticle

Screening
Molecules
Sirtuins
Scaffolds
Chemical activation
9 Citations (Scopus)

Pharmacophore modeling, virtual screening and molecular docking studies for identification of new inverse agonists of human histamine H1 receptor

Thangapandian, S., Krishnamoorthy, N., John, S., Sakkiah, S., Lazar, P., Lee, Y. & Lee, K. W., 1 Jan 2010, In : Bulletin of the Korean Chemical Society. 31, 1, p. 52-58 7 p.

Research output: Contribution to journalArticle

Histamine H1 Receptors
Screening
Anti-Allergic Agents
Molecules
Rhodopsin
22 Citations (Scopus)

Probing possible egress channels for multiple ligands in human CYP3A4: A molecular modeling study

Krishnamoorthy, N., Gajendrarao, P., Thangapandian, S., Lee, Y. & Lee, K. W., 1 Jan 2010, In : Journal of Molecular Modeling. 16, 4, p. 607-614 8 p.

Research output: Contribution to journalArticle

egress
Cytochrome P-450 CYP3A
Molecular modeling
Ligands
ligands
4 Citations (Scopus)

Structural modeling of p.V31F variant in the aspartoacylase gene

Krishnamoorthy, N. & Zayed, H., 21 Jan 2016, (Accepted/In press) In : Metabolic Brain Disease. p. 1-4 4 p.

Research output: Contribution to journalArticle

Canavan Disease
Genes
Brain
Genetic Association Studies
Enzymes
7 Citations (Scopus)

Targeted sequencing identifies novel variants involved in autosomal recessive hereditary hearing loss in Qatari families

Al-Kowari, M. K., Vozzi, D., Bhagat, S., Krishnamoorthy, N., Morgan, A., Hayder, Y., Logendra, B. W., Najjar, N., Gandin, I., Gasparini, P., Badii, R., Girotto, G. & Abdulhadi, K., 1 Aug 2017, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 800-802, p. 29-36 8 p.

Research output: Contribution to journalArticle

Hearing Loss
Alleles
Genes
Genetic Heterogeneity
Molecular Pathology
45 Citations (Scopus)

The CYP3A4*18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density

Kang, Y. S., Park, S. Y., Yim, C. H., Kwak, H. S., Gajendrarao, P., Krishnamoorthy, N., Yun, S. C., Lee, K. W. & Han, K. O., 1 Mar 2009, In : Clinical Pharmacology and Therapeutics. 85, 3, p. 312-318 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Bone Density
Steroids
Genotype
Genes
3 Citations (Scopus)

The Role of Cardiac Myosin Binding Protein C3 in Hypertrophic Cardiomyopathy-Progress and Novel Therapeutic Opportunities

Mohamed, I. A., Krishnamoorthy, N., Nasrallah, G. K. & Da'as, S., 1 Jul 2017, In : Journal of Cellular Physiology. 232, 7, p. 1650-1659 10 p.

Research output: Contribution to journalReview article

Cardiac Myosins
Hypertrophic Cardiomyopathy
Carrier Proteins
Genes
Mutation
17 Citations (Scopus)

Two patients with Canavan disease and structural modeling of a novel mutation

Zaki, O. K., Krishnamoorthy, N., El Abd, H. S., Harche, S. A., Mattar, R. A., Al Disi, R. S., Nofal, M. Y., El Bekay, R., Ahmed, K. A., George Priya Doss, C. & Zayed, H., 17 Aug 2016, (Accepted/In press) In : Metabolic Brain Disease. p. 1-7 7 p.

Research output: Contribution to journalArticle

Canavan Disease
Mutation
Missense Mutation
Inborn Genetic Diseases
Molecular modeling