• 1314 Citations
  • 19 h-Index
1992 …2019
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Research Output 1992 2019

  • 1314 Citations
  • 19 h-Index
  • 37 Article
  • 1 Chapter
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Article
2019

DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation

Arredouani, A., Diane, A., Khattab, N., Bensmail, I., Aoude, I., Chikri, M., Mohammad, R., Abou-Samra, A. B. & Dehbi, M., 1 Dec 2019, In : Scientific reports. 9, 1, 4772.

Research output: Contribution to journalArticle

Open Access
Physiological Stress
Glucose
Luciferases
Type 2 Diabetes Mellitus
Insulin Resistance
2018

DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases

Khadir, A., Kavalakatt, S., Dehbi, M., Alarouj, M., Bennakhi, A., Tiss, A. & Elkum, N., 1 Jan 2018, In : Disease Markers. 2018, 9529621.

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 1
Cardiovascular Diseases
Inflammation
Plasmas
Kuwait
4 Citations (Scopus)

Physical exercise enhanced heat shock protein 60 expression and attenuated inflammation in the adipose tissue of human diabetic obese

Khadir, A., Kavalakatt, S., Cherian, P., Warsame, S., Abubaker, J. A., Dehbi, M. & Tiss, A., 6 Feb 2018, In : Frontiers in Endocrinology. 9, FEB, 16.

Research output: Contribution to journalArticle

Chaperonin 60
Adipose Tissue
Exercise
Inflammation
Subcutaneous Fat
2016
19 Citations (Scopus)

Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone

Khadir, A., Kavalakatt, S., Abubaker, J., Cherian, P., Madhu, D., Al-Khairi, I., Abu-Farha, M., Warsame, S., Elkum, N., Dehbi, M. & Tiss, A., 1 Sep 2016, In : Metabolism: Clinical and Experimental. 65, 9, p. 1409-1420 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Unfolded Protein Response
Exercise
Endoplasmic Reticulum
Subcutaneous Fat
2015
15 Citations (Scopus)

DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression

Abu-Farha, M., Cherian, P., Al-Khairi, I., Tiss, A., Khadir, A., Kavalakatt, S., Warsame, S., Dehbi, M., Behbehani, K. & Abubaker, J., 24 Sep 2015, In : Scientific Reports. 5, 14448.

Research output: Contribution to journalArticle

Phosphorylation
Insulin
Insulin Resistance
Glucose
Type 2 Diabetes Mellitus
7 Citations (Scopus)

Gender-specific association of oxidative stress and inflammation with cardiovascular risk factors in Arab population

Khadir, A., Tiss, A., Kavalakatt, S., Behbehani, K., Dehbi, M. & Elkum, N., 2015, In : Mediators of Inflammation. 2015, 512603.

Research output: Contribution to journalArticle

Oxidative Stress
Inflammation
Interleukin-6
Cardiovascular Diseases
Abdominal Obesity
22 Citations (Scopus)

Map kinase phosphatase dusp1 is overexpressed in obese humans and modulated by physical exercise

Khadir, A., Tiss, A., Abubaker, J., Abu-Farha, M., Al-Khairi, I., Cherian, P., John, J., Kavalakatt, S., Warsame, S., Al-Madhoun, A., Al-Ghimlas, F., Elkum, N., Behbehani, K., Dermime, S. & Dehbi, M., 1 Jan 2015, In : American Journal of Physiology - Endocrinology and Metabolism. 308, 1, p. E71-E83

Research output: Contribution to journalArticle

Dual Specificity Phosphatase 1
Protein Phosphatase 1
Phosphoric Monoester Hydrolases
Phosphotransferases
Exercise
2014
9 Citations (Scopus)

Gender differences in ghrelin association with cardiometabolic risk factors in arab population

Abu-Farha, M., Dehbi, M., Noronha, F., Tiss, A., Alarouj, M., Behbehani, K., Bennakhi, A. & Elkum, N., 2014, In : International Journal of Endocrinology. 2014, 730472.

Research output: Contribution to journalArticle

Ghrelin
Population
Insulin Resistance
Arab World
Kuwait
27 Citations (Scopus)

IL-33 is negatively associated with the BMI and confers a protective lipid/metabolic profile in non-diabetic but not diabetic subjects

Hasan, A., Al-Ghimlas, F., Warsame, S., Al-Hubail, A., Ahmad, R., Bennakhi, A., Al-Arouj, M., Behbehani, K., Dehbi, M. & Dermime, S., 10 May 2014, In : BMC Immunology. 15, 1, 19.

Research output: Contribution to journalArticle

Metabolome
Lipids
Atherosclerosis
Serum
Body Weight
21 Citations (Scopus)

Immunohistochemical profiling of the heat shock response in obese non-diabetic subjects revealed impaired expression of heat shock proteins in the adipose tissue

Tiss, A., Khadir, A., Abubaker, J., Abu-Farha, M., Al-Khairi, I., Cherian, P., John, J., Kavalakatt, S., Warsame, S., Al-Ghimlas, F., Elkum, N., Behbehani, K., Dermime, S. & Dehbi, M., 1 Jul 2014, In : Lipids in Health and Disease. 13, 1, 106.

Research output: Contribution to journalArticle

Heat-Shock Response
Heat-Shock Proteins
HSP72 Heat-Shock Proteins
Adipose Tissue
Chemokine CCL5
19 Citations (Scopus)

Physical exercise reduces the expression of RANTES and its CCR5 receptor in the adipose tissue of obese humans

Baturcam, E., Abubaker, J., Tiss, A., Abu-Farha, M., Khadir, A., Al-Ghimlas, F., Al-Khairi, I., Cherian, P., Elkum, N., Hammad, M., John, J., Kavalakatt, S., Lehe, C., Warsame, S., Behbehani, K., Dermime, S. & Dehbi, M., 1 Jan 2014, In : Mediators of Inflammation. 2014, 627150.

Research output: Contribution to journalArticle

CCR5 Receptors
Chemokine CCL5
Adipose Tissue
Exercise
Subcutaneous Fat
2013
29 Citations (Scopus)

DNAJB3/HSP-40 Cochaperone Is Downregulated in Obese Humans and Is Restored by Physical Exercise

Abubaker, J., Tiss, A., Abu-Farha, M., Al-Ghimlas, F., Al-Khairi, I., Baturcam, E., Cherian, P., Elkum, N., Hammad, M., John, J., Kavalakatt, S., Khadir, A., Warsame, S., Dermime, S., Behbehani, K. & Dehbi, M., 24 Jul 2013, In : PLoS One. 8, 7, e69217.

Research output: Contribution to journalArticle

exercise
obesity
Down-Regulation
Obesity
Exercise
48 Citations (Scopus)

Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity

Abu-Farha, M., Tiss, A., Abubaker, J., Khadir, A., Al-Ghimlas, F., Al-Khairi, I., Baturcam, E., Cherian, P., Elkum, N., Hammad, M., John, J., Kavalakatt, S., Warsame, S., Behbehani, K., Dermime, S. & Dehbi, M., 24 Sep 2013, In : PLoS One. 8, 9, e75342.

Research output: Contribution to journalArticle

histone deacetylase
Histone Deacetylases
Epigenomics
epigenetics
Proteomics
2012
19 Citations (Scopus)

Tissue factor/factor VIIa pathway mediates coagulation activation in induced-heat stroke in the baboon

Bouchama, A., Al-Mohanna, F., Assad, L., Baturcam, E., Eldali, A., Owaidah, T. & Dehbi, M., 1 Apr 2012, In : Critical Care Medicine. 40, 4, p. 1229-1236 8 p.

Research output: Contribution to journalArticle

Heat Stroke
Factor VIIa
Papio
Thromboplastin
Fibrinolysis
16 Citations (Scopus)

Toll-Like Receptor 4 and High-Mobility Group Box 1 Are Critical Mediators of Tissue Injury and Survival in a Mouse Model for Heatstroke

Dehbi, M., Uzzaman, T., Baturcam, E., Eldali, A., Ventura, W. & Bouchama, A., 4 Sep 2012, In : PLoS One. 7, 9, e44100.

Research output: Contribution to journalArticle

Heat Stroke
Tissue Survival
Toll-Like Receptor 4
animal models
Tissue
2011
34 Citations (Scopus)

Genome annotation and intraviral interactome for the streptococcus pneumoniae virulent phage Dp-1

Sabri, M., Häuser, R., Ouellette, M., Liu, J., Dehbi, M., Moeck, G., García, E., Titz, B., Uetz, P. & Moineau, S., 1 Jan 2011, In : Journal of Bacteriology. 193, 2, p. 551-562 12 p.

Research output: Contribution to journalArticle

Streptococcus pneumoniae
Bacteriophages
Genome
Nucleoside Q
Streptococcus Phages
17 Citations (Scopus)

SRAGE in diabetic and non-diabetic critically ill patients: Effects of intensive insulin therapy

Arabi, Y. M., Dehbi, M., Rishu, A. H., Baturcam, E., Kahoul, S. H., Brits, R. J., Naidu, B. & Bouchama, A., 26 Sep 2011, In : Critical Care. 15, 4, R203.

Research output: Contribution to journalArticle

Critical Illness
Insulin
Thrombomodulin
Interleukin-6
Therapeutics
2010
21 Citations (Scopus)

Hsp-72, a candidate prognostic indicator of heatstroke

Dehbi, M., Baturcam, E., Eldali, A., Ahmed, M., Kwaasi, A., Chishti, M. A. & Bouchama, A., 1 Sep 2010, In : Cell Stress and Chaperones. 15, 5, p. 593-603 11 p.

Research output: Contribution to journalArticle

HSP72 Heat-Shock Proteins
Heat Stroke
Hot Temperature
Papio
Heat-Shock Proteins
2009
11 Citations (Scopus)

Inhibition of transcription in Staphylococcus aureus by a primary sigma factor-binding polypeptide from phage G1

Dehbi, M., Moeck, G., Arhin, F. F., Bauda, P., Bergeron, D., Kwan, T., Liu, J., McCarty, J., DuBow, M. & Pelletier, J., 1 Jun 2009, In : Journal of Bacteriology. 191, 12, p. 3763-3771 9 p.

Research output: Contribution to journalArticle

Sigma Factor
DNA-Directed RNA Polymerases
Bacteriophages
Staphylococcus aureus
Peptides
2008
36 Citations (Scopus)

Recombinant activated protein c attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke

Bouchama, A., Kunzelmann, C., Dehbi, M., Kwaasi, A., Eldali, A., Zobairi, F., Freyssinet, J. M. & De Prost, D., 1 Jul 2008, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 7, p. 1318-1325 8 p.

Research output: Contribution to journalArticle

Heat Stroke
Papio
Protein C
Recombinant Proteins
Wounds and Injuries
2007
112 Citations (Scopus)

Cooling and hemodynamic management in heatstroke: Practical recommendations

Bouchama, A., Dehbi, M. & Chaves-Carballo, E., 12 May 2007, In : Critical Care. 11, R54.

Research output: Contribution to journalArticle

Heat Stroke
Hemodynamics
Sunstroke
Heat Stress Disorders
Shock
19 Citations (Scopus)

Glucocorticoids do not protect against the lethal effects of experimental heatstroke in baboons

Bouchama, A., Kwaasi, A., Dehbi, M., Al Mohanna, F., Eldali, A., El-Sayed, R., Tbakhi, A., Alzahrani, A. S. & Roberts, G., 1 May 2007, In : Shock. 27, 5, p. 578-583 6 p.

Research output: Contribution to journalArticle

Heat Stroke
Papio
Dexamethasone
Glucocorticoids
Interleukin-6
225 Citations (Scopus)

Prognostic factors in heat wave-related deaths: A meta-analysis

Bouchama, A., Dehbi, M., Mohamed, G., Matthies, F., Shoukri, M. & Menne, B., 12 Nov 2007, In : Archives of Internal Medicine. 167, 20, p. 2170-2176 7 p.

Research output: Contribution to journalArticle

Infrared Rays
Meta-Analysis
Odds Ratio
Confidence Intervals
Heat Stroke
2006
40 Citations (Scopus)

A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus1

Arhin, F., Bélanger, O., Ciblat, S., Dehbi, M., Delorme, D., Dietrich, E., Dixit, D., Lafontaine, Y., Lehoux, D., Liu, J., McKay, G. A., Moeck, G., Reddy, R., Rose, Y., Srikumar, R., Tanaka, K. S. E., Williams, D. M., Gros, P., Pelletier, J., Parr, T. R. & 1 others, Far, A. R., 1 Sep 2006, In : Bioorganic and Medicinal Chemistry. 14, 17, p. 5812-5832 21 p.

Research output: Contribution to journalArticle

DNA-Directed RNA Polymerases
Rifampin
Staphylococcus
Molecules
Bacterial RNA
15 Citations (Scopus)

Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus

Belley, A., Callejo, M., Arhin, F., Dehbi, M., Fadhil, I., Liu, J., McKay, G., Srikumar, R., Bauda, P., Ha, N., DuBow, M., Gros, P., Pelletier, J. & Moeck, G., 1 Nov 2006, In : Molecular Microbiology. 62, 4, p. 1132-1143 12 p.

Research output: Contribution to journalArticle

DNA-Binding Proteins
DNA Replication
Bacteriophages
Staphylococcus aureus
Peptides

Erratum: Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus (Molecular Microbiology (2006) 62 (1132-1143))

Belley, A., Callejo, M., Arhin, F., Dehbi, M., Fadhil, I., Liu, J., McKay, G., Srikumar, R., Bauda, P., Bergeron, D., Ha, N., DuBow, M., Gros, P., Pelletier, J. & Moeck, G., 1 Dec 2006, In : Molecular Microbiology. 62, 6

Research output: Contribution to journalArticle

2004
155 Citations (Scopus)

Antimicrobial drug discovery through bacteriophage genomics

Liu, J., Dehbi, M., Moeck, G., Arhin, F., Banda, P., Bergeron, D., Callejo, M., Ferretti, V., Ha, N., Kwan, T., McCarty, J., Srikumar, R., Williams, D., Wu, J. J., Gros, P., Pelletier, J. & DuBow, M., 1 Feb 2004, In : Nature Biotechnology. 22, 2, p. 185-191 7 p.

Research output: Contribution to journalArticle

Bacteriophages
Drug Discovery
Genomics
Polypeptides
Staphylococcus aureus
1998
28 Citations (Scopus)

Activation of the wt1 Wilms' tumor suppressor gene by NF-κB

Dehbi, M., Hiscott, J. & Pelletier, J., 23 Apr 1998, In : Oncogene. 16, 16, p. 2033-2039 7 p.

Research output: Contribution to journalArticle

Wilms' Tumor Genes
Tumor Suppressor Genes
Binding Sites
Urogenital System
Trans-Activators
1997
5 Citations (Scopus)

Overlapping DNA recognition motifs between Sp1 and a novel trans-acting factor within the wt1 tumour suppressor gene promoter

Discenza, M. T., Dehbi, M. & Pelletier, J., 1 Nov 1997, In : Nucleic Acids Research. 25, 21, p. 4314-4322 9 p.

Research output: Contribution to journalArticle

Nucleotide Motifs
Trans-Activators
Electrophoretic Mobility Shift Assay
Tumor Suppressor Genes
Paired Box Transcription Factors
1996
7 Citations (Scopus)

Multiple signaling pathways control the activation of the CEF-4/9E3 cytokine gene by pp60(v-src)

Bojović, B., Rodrigues, N., Dehbi, M. & Bédard, P. A., 25 Sep 1996, In : Journal of Biological Chemistry. 271, 37, p. 22528-22537 10 p.

Research output: Contribution to journalArticle

Oncogene Protein pp60(v-src)
Fibroblasts
Chickens
Embryonic Structures
Genes
58 Citations (Scopus)

PAX8-mediated activation of the wt1 tumor suppressor gene

Dehbi, M. & Pelletier, J., 15 Aug 1996, In : EMBO Journal. 15, 16, p. 4297-4306 10 p.

Research output: Contribution to journalArticle

Tumor Suppressor Genes
Gene expression
Tumors
Epithelial-Mesenchymal Transition
Genes
120 Citations (Scopus)

The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1)

Dehbi, M., Ghahremani, M., Lechner, M., Dressler, G. & Pelletier, J., 10 Sep 1996, In : Oncogene. 13, 3, p. 447-453 7 p.

Research output: Contribution to journalArticle

Paired Box Transcription Factors
Wilms' Tumor Genes
Tumor Suppressor Genes
Epithelium
Urogenital System
1995
97 Citations (Scopus)

Repression of the retinoic acid receptor-α gene by the Wilms' tumor suppressor gene product, wt1

Goodyer, P., Dehbi, M., Torban, E., Bruening, W. & Pelletier, J., 1 Jan 1995, In : Oncogene. 10, 6, p. 1125-1129 5 p.

Research output: Contribution to journalArticle

Wilms' Tumor Genes
Retinoic Acid Receptors
Tumor Suppressor Genes
Nucleotide Motifs
Germ-Line Mutation
1994
5 Citations (Scopus)

Activation of human immunodeficiency virus 1 gene expression by the src oncoprotein

Dehbi, M., Beaulieu, S., Cohen, E. A. & Bédard, P. A., 1 Aug 1994, In : Oncogene. 9, 8, p. 2399-2403 5 p.

Research output: Contribution to journalArticle

Oncogene Protein pp60(v-src)
Oncogene Proteins
HIV-1
Gene Expression
HIV Long Terminal Repeat
6 Citations (Scopus)

Biosynthesis and polarized distribution of neutral endopeptidase in primary cultures of kidney proximal tubule cells

Jalal, F., Dehbi, M., Berteloot, A. & Crine, P., 1 Jan 1994, In : Biochemical Journal. 302, 3, p. 669-674 6 p.

Research output: Contribution to journalArticle

Neprilysin
Proximal Kidney Tubule
Biosynthesis
Molecules
Cell membranes
1992
12 Citations (Scopus)

Regulation of gene expression in oncogenically transformed cells.

Dehbi, M. & Bédard, P. A., 1 Oct 1992, In : Biochemistry and cell biology = Biochimie et biologie cellulaire. 70, 10-11, p. 980-997 18 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Gene expression
Transcription Factors
Chemical activation
Genes
34 Citations (Scopus)

Transcriptional activation of the CEF-4/9E3 cytokine gene by pp60v-src

Dehbi, M., Mbiguino, A., Beauchemin, M., Chatelain, G. & Bédard, P. A., 1 Apr 1992, In : Molecular and Cellular Biology. 12, 4, p. 1490-1499 10 p.

Research output: Contribution to journalArticle

src Genes
Transcription Factor AP-1
Rous sarcoma virus
Transcriptional Activation
Cytokines