Manikkam Suthanthiran

Professor

  • 12666 Citations
  • 52 h-Index
1977 …2020

Research output per year

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Research Output

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Article
2020

Separating the signal from the noise in metagenomic cell-free DNA sequencing

Burnham, P., Gomez-Lopez, N., Heyang, M., Cheng, A. P., Lenz, J. S., Dadhania, D. M., Lee, J. R., Suthanthiran, M., Romero, R. & De Vlaminck, I., 11 Feb 2020, In : Microbiome. 8, 1, 18.

Research output: Contribution to journalArticle

Open Access

Urinary cell transcriptomics and acute rejection in human kidney allografts

Verma, A., Muthukumar, T., Yang, H., Lubetzky, M., Cassidy, M. F., Lee, J. R., Dadhania, D. M., Snopkowski, C., Shankaranarayanan, D., Salvatore, S. P., Sharma, V. K., Xiang, J. Z., De Vlaminck, I., Seshan, S. V., Mueller, F. B., Suhre, K., Elemento, O. & Suthanthiran, M., 27 Feb 2020, In : JCI Insight. 5, 4, e131552.

Research output: Contribution to journalArticle

Open Access
2019

A cell-free DNA metagenomic sequencing assay that integrates the host injury response to infection

Cheng, A. P., Burnham, P., Lee, J. R., Cheng, M. P., Suthanthiran, M., Dadhania, D. & De Vlaminck, I., 10 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18738-18744 7 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study

Lee, J. R., Huang, J., Magruder, M., Zhang, L. T., Gong, C., Sholi, A. N., Albakry, S., Edusei, E., Muthukumar, T., Lubetzky, M., Dadhania, D. M., Taur, Y., Pamer, E. G. & Suthanthiran, M., 1 Dec 2019, In : Transplant Infectious Disease. 21, 6, e13180.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Gastrointestinal pathogen colonization and the microbiome in asymptomatic kidney transplant recipients

Westblade, L. F., Satlin, M. J., Albakry, S., Botticelli, B., Robertson, A., Alston, T., Magruder, M., Zhang, L. T., Edusei, E., Chan, K., Lubetzky, M., Dadhania, D. M., Pamer, E. G., Suthanthiran, M. & Lee, J. R., 1 Dec 2019, In : Transplant Infectious Disease. 21, 6, e13167.

Research output: Contribution to journalArticle

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection

Magruder, M., Sholi, A. N., Gong, C., Zhang, L., Edusei, E., Huang, J., Albakry, S., Satlin, M. J., Westblade, L. F., Crawford, C., Dadhania, D. M., Lubetzky, M., Taur, Y., Littman, E., Ling, L., Burnham, P., De Vlaminck, I., Pamer, E., Suthanthiran, M. & Lee, J. R., 1 Dec 2019, In : Nature communications. 10, 1, 5521.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Landscape of innate immune system transcriptome and acute T cell–mediated rejection of human kidney allografts

Mueller, F. B., Yang, H., Lubetzky, M., Verma, A., Lee, J. R., Dadhania, D. M., Xiang, J. Z., Salvatore, S. P., Seshan, S. V., Sharma, V. K., Elemento, O., Suthanthiran, M. & Muthukumar, T., 11 Jul 2019, In : JCI Insight. 4, 13, :e128014.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)
2018

A tribute to Terry Strom

Turka, L. A. & Suthanthiran, M., 1 Mar 2018, In : The Journal of clinical investigation. 128, 3, p. 891-892 2 p.

Research output: Contribution to journalArticle

Open Access

Gut microbiota dysbiosis and diarrhea in kidney transplant recipients

Lee, J. R., Magruder, M., Zhang, L., Westblade, L. F., Satlin, M. J., Robertson, A., Edusei, E., Crawford, C., Ling, L., Taur, Y., Schluter, J., Lubetzky, M., Dadhania, D., Pamer, E. & Suthanthiran, M., 1 Jan 2018, (Accepted/In press) In : American Journal of Transplantation.

Research output: Contribution to journalArticle

10 Citations (Scopus)

MicroRNAs and Transplantation

Khan, Z., Suthanthiran, M. & Muthukumar, T., 1 Jan 2018, (Accepted/In press) In : Clinics in Laboratory Medicine.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Single nucleotide variant counts computed from RNA sequencing and cellular traffic into human kidney allografts

Thareja, G., Yang, H., Hayat, S., Mueller, F. B., Lee, J. R., Lubetzky, M., Dadhania, D. M., Belkadi, A., Seshan, S. V., Suhre, K., Suthanthiran, M. & Muthukumar, T., 1 Jan 2018, (Accepted/In press) In : American Journal of Transplantation.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract

Burnham, P., Dadhania, D., Heyang, M., Chen, F., Westblade, L. F., Suthanthiran, M., Lee, J. R. & De Vlaminck, I., 1 Dec 2018, In : Nature Communications. 9, 1, 2412.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Urine biomarkers informative of human kidney allograft rejection and tolerance

Nissaisorakarn, V., Lee, J. R., Lubetzky, M. & Suthanthiran, M., 1 Jan 2018, (Accepted/In press) In : Human Immunology.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Kidney allograft failure in the steroid-free immunosuppression era: A matched case-control study

Alkadi, M. M., Kim, J., Aull, M. J., Schwartz, J. E., Lee, J. R., Watkins, A., Lee, J. B., Dadhania, D. M., Seshan, S. V., Serur, D., Kapur, S., Suthanthiran, M., Hartono, C. & Muthukumar, T., 1 Nov 2017, In : Clinical Transplantation. 31, 11, e13117.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Acute Rejection, Kidney Allograft Function, and Graft Survival in Patients with Circulating Pre-Transplant IgG Antibodies Directed Against Donor HLA-A, -B, or -C Locus Determined Antigens

Abuhelaiqa, E., Friedlander, R., Aull, M., Putheti, P., Sharma, V., Suthanthiran, M. & Dadhania, D., 1 Jan 2016, In : Clinical transplants. 32, p. 83-91 9 p.

Research output: Contribution to journalArticle

Exome Sequencing and Prediction of Long-Term Kidney Allograft Function

Mesnard, L., Muthukumar, T., Burbach, M., Li, C., Shang, H., Dadhania, D., Lee, J. R., Sharma, V. K., Xiang, J., Suberbielle, C., Carmagnat, M., Ouali, N., Rondeau, E., Friedewald, J. J., Abecassis, M. M., Suthanthiran, M. & Campagne, F., Sep 2016, In : PLoS Computational Biology. 12, 9, e1005088.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Urine metabolite profiles predictive of human kidney allograft status

Suhre, K., Schwartz, J. E., Sharma, V. K., Chen, Q., Lee, J. R., Muthukumar, T., Dadhania, D. M., DIng, R., Ikle, D. N., Bridges, N. D., Williams, N. M., Kastenmüller, G., Karoly, E. D., Mohney, R. P., Abecassis, M., Friedewald, J., Knechtle, S. J., Becker, Y. T., Samstein, B., Shaked, A. & 2 others, Gross, S. S. & Suthanthiran, M., 1 Feb 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 626-636 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2015

Characteristics of circulating donor human leukocyte antigen-specific immunoglobulin G antibodies predictive of acute antibody-mediated rejection and kidney allograft failure

Kannabhiran, D., Lee, J., Schwartz, J. E., Friedlander, R., Aull, M., Muthukumar, T., Campbell, S., Epstein, D., Seshan, S. V., Kapur, S., Sharma, V. K., Suthanthiran, M. & Dadhania, D., 1 Jan 2015, In : Transplantation. 99, 6, p. 1156-1164 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Design and implementation of the international genetics and translational research in transplantation network

The International Genetics & Translational Research in Transplantation Network (iGeneTRAiN), 23 Oct 2015, In : Transplantation. 99, 11, p. 2401-2412 12 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Gut microbiota and tacrolimus dosing in kidney transplantation

Lee, J. R., Muthukumar, T., Dadhania, D., Taur, Y., Jenq, R. R., Toussaint, N. C., Ling, L., Pamer, E. & Suthanthiran, M., 27 Mar 2015, In : PLoS One. 10, 3, e0122399.

Research output: Contribution to journalArticle

47 Citations (Scopus)
2014

Circulating levels of 25-hydroxyvitamin D and acute cellular rejection in kidney allograft recipients

Lee, J. R., Dadhania, D., August, P., Lee, J. B., Suthanthiran, M. & Muthukumar, T., 15 Aug 2014, In : Transplantation. 98, 3, p. 292-299 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Gut microbial community structure and complications after kidney transplantation: A pilot study

Lee, J. R., Muthukumar, T., Dadhania, D., Toussaint, N. C., Ling, L., Pamer, E. & Suthanthiran, M., 15 Oct 2014, In : Transplantation. 98, 7, p. 697-705 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Hypertension, kidney disease, HIV and antiretroviral therapy among Tanzanian adults: A cross-sectional study

Peck, R. N., Shedafa, R., Kalluvya, S., Downs, J. A., Todd, J., Suthanthiran, M., Fitzgerald, D. W. & Kataraihya, J. B., 29 Jul 2014, In : BMC Medicine. 12, 1, 125.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Urinary cell mRNA profiles and differential diagnosis of acute kidney graft dysfunction

Matignon, M., Ding, R., Dadhania, D. M., Mueller, F. B., Hartono, C., Snopkowski, C., Li, C., Lee, J. R., Sjoberg, D., Seshan, S. V., Sharma, V. K., Yang, H., Nour, B., Vickers, A. J., Suthanthiran, M. & Muthukumar, T., 1 Jul 2014, In : Journal of the American Society of Nephrology. 25, 7, p. 1586-1597 12 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
2013

Genomic biomarkers correlate with HLA-identical renal transplant tolerance

Leventhal, J. R., Mathew, J. M., Salomon, D. R., Kurian, S. M., Suthanthiran, M., Tambur, A., Friedewald, J., Gallon, L., Charette, J., Levitsky, J., Kanwar, Y., Abecassis, M. & Miller, J., 1 Sep 2013, In : Journal of the American Society of Nephrology. 24, 9, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

HIV-infected kidney graft recipients managed with an early corticosteroid withdrawal protocol: Clinical outcomes and messenger RNA profiles

Muthukumar, T., Afaneh, C., Ding, R., Tsapepas, D., Lubetzky, M., Jacobs, S., Lee, J., Sharma, V., Lee, J., Dadhania, D., Hartono, C., McDermott, J., Aull, M., Leeser, D., Kapur, S., Serur, D. & Suthanthiran, M., 15 Mar 2013, In : Transplantation. 95, 5, p. 711-720 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

HLA identical non-chimeric and HLA disparate chimeric renal transplant tolerance.

Leventhal, J. R., Mathew, J. M., Ildstad, S., Salomon, D. R., Kurian, S. M., Suthanthiran, M., Tambur, A., Friedewald, J., Gallon, L., Charette, J., Levitsky, J., Kanwar, Y., Abecassis, M. & Miller, J., 1 Jan 2013, In : Clinical transplants. p. 145-156 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Immunosuppressive drug therapy

Hartono, C., Muthukumar, T. & Suthanthiran, M., 17 Sep 2013, In : Cold Spring Harbor Perspectives in Medicine. 3, 9

Research output: Contribution to journalArticle

36 Citations (Scopus)

Independent risk factors for urinary tract infection and for subsequent bacteremia or acute cellular rejection: A single-center report of 1166 kidney allograft recipients

Lee, J. R., Bang, H., Dadhania, D., Hartono, C., Aull, M. J., Satlin, M., August, P., Suthanthiran, M. & Muthukumar, T., 27 Oct 2013, In : Transplantation. 96, 8, p. 732-738 7 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling

Keslar, K. S., Lin, M., Zmijewska, A. A., Sigdel, T. K., Tran, T. Q., Ma, L., Bhasin, M., Rao, P., Ding, R., Iklé, D. N., Mannon, R. B., Sarwal, M. M., Strom, T. B., Reed, E. F., Heeger, P. S., Suthanthiran, M. & Fairchild, R. L., 1 Jul 2013, In : American Journal of Transplantation. 13, 7, p. 1891-1897 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Noninvasive prognostication of polyomavirus BK virus-associated nephropathy

Dadhania, D., Snopkowski, C., Muthukumar, T., Lee, J., Ding, R., Sharma, V. K., Christos, P., Bang, H., Kapur, S., Seshan, S. V. & Suthanthiran, M., 27 Jul 2013, In : Transplantation. 96, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Urinary-cell mRNA profile and acute cellular rejection in kidney allografts

Suthanthiran, M., Schwartz, J. E., Ding, R., Abecassis, M., Dadhania, D., Samstein, B., Knechtle, S. J., Friedewald, J., Becker, Y. T., Sharma, V. K., Williams, N. M., Chang, C. S., Hoang, C., Muthukumar, T., August, P., Keslar, K. S., Fairchild, R. L., Hricik, D. E., Heeger, P. S., Han, L. & 5 others, Liu, J., Riggs, M., Ikle, D. N., Bridges, N. D. & Shaked, A., 1 Jan 2013, In : New England Journal of Medicine. 369, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)

Urinary-cell MRNA profile and acute cellular rejection in kidney allografts

Suthanthiran, M., Schwartz, J. E., Ding, R., Abecassis, M., Dadhania, D., Samstein, B., Knechtle, S. J., Friedewald, J., Becker, Y. T., Sharma, V. K., Williams, N. M., Chang, C. S., Hoang, C., Muthukumar, T., August, P., Keslar, K. S., Fairchild, R. L., Hricik, D. E., Heeger, P. S., Han, L. & 5 others, Liu, J., Riggs, M., Ikle, D. N., Bridges, N. D. & Shaked, A., Dec 2013, In : Journal of Urology. 190, 6, p. 2175-2176 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2012

Angiogenic factors in superimposed preeclampsia: A longitudinal study of women with chronic hypertension during pregnancy

Perni, U., Sison, C., Sharma, V., Helseth, G., Hawfield, A., Suthanthiran, M. & August, P., 1 Mar 2012, In : Hypertension. 59, 3, p. 740-746 7 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Concurrent acute cellular rejection is an independent risk factor for renal allograft failure in patients with C4d-positive antibody-mediated rejection

Matignon, M., Muthukumar, T., Seshan, S. V., Suthanthiran, M. & Hartono, C., 27 Sep 2012, In : Transplantation. 94, 6, p. 603-611 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Dendritic cells with TGF-β1 and IL-2 differentiate naive CD4+ T Cells into alloantigen-specific and allograft protective foxp3+ regulatory T cells

Yang, H., Cheng, E. Y., Sharma, V. K., Lagman, M., Chang, C., Song, P., Ding, R., Muthukumar, T. & Suthanthiran, M., 27 Mar 2012, In : Transplantation. 93, 6, p. 580-588 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Discovery and validation of a molecular signature for the noninvasive diagnosis of human renal allograft fibrosis

Anglicheau, D., Muthukumar, T., Hummel, A., Ding, R., Sharma, V. K., Dadhania, D., Seshan, S. V., Schwartz, J. E. & Suthanthiran, M., 15 Jun 2012, In : Transplantation. 93, 11, p. 1136-1146 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Early corticosteroid withdrawal in recipients of renal allografts: A single-center report of ethnically diverse recipients and recipients of marginal deceased-donor kidneys

Aull, M. J., Dadhania, D., Afaneh, C., Leeser, D. B., Hartono, C., Lee, J. B., Serur, D., Del Pizzo, J. J., Suthanthiran, M. & Kapur, S., 27 Oct 2012, In : Transplantation. 94, 8, p. 837-844 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Excretion of anti-angiogenic proteins in patients with chronic allograft dysfunction

Moskowitz-Kassai, E., MacKelaite, L., Chen, J., Patel, K., Dadhania, D. M., Gross, S. S., Chander, P., Delaney, V., Deng, L., Chen, L., Cui, X., Suthanthiran, M. & Goligorsky, M. S., 1 Feb 2012, In : Nephrology Dialysis Transplantation. 27, 2, p. 494-497 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mean arterial blood pressure while awaiting kidney transplantation is associated with the risk of primary nonfunction

Webber, A., Hambleton, J., Chami, A., Bang, H., Seshan, S., Sharma, A., August, P., Kapur, S., Suthanthiran, M. & Dadhania, D., 15 Jan 2012, In : Transplantation. 93, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

MicroRNA sequence profiles of human kidney allografts with or without tubulointerstitial fibrosis

Ben-Dov, I. Z., Muthukumar, T., Morozov, P., Mueller, F. B., Tuschl, T. & Suthanthiran, M., 15 Dec 2012, In : Transplantation. 94, 11, p. 1086-1094 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2010

Banff '09 meeting report: Antibody mediated graft deterioration and implementation of Banff working groups

Sis, B., Mengel, M., Haas, M., Colvin, R. B., Halloran, P. F., Racusen, L. C., Solez, K., Baldwin, W. M., Bracamonte, E. R., Broecker, V., Cosio, F., Demetris, A. J., Drachenberg, C., Einecke, G., Gloor, J., Glotz, D., Kraus, E., Legendre, C., Liapis, H., Mannon, R. B. & 13 others, Nankivell, B. J., Nickeleit, V., Papadimitriou, J. C., Randhawa, P., Regele, H., Renaudin, K., Rodriguez, E. R., Seron, D., Seshan, S., Suthanthiran, M., Wasowska, B. A., Zachary, A. & Zeevi, A., Mar 2010, In : American Journal of Transplantation. 10, 3, p. 464-471 8 p.

Research output: Contribution to journalArticle

572 Citations (Scopus)

Diannexin decreases inflammatory cell infiltration into the islet graft, reduces β-cell apoptosis, and improves early graft function

Cheng, E. Y., Sharma, V. K., Chang, C., Ding, R., Allison, A. C., Leeser, D. B., Suthanthiran, M. & Yang, H., 15 Oct 2010, In : Transplantation. 90, 7, p. 709-716 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Identification of a B cell signature associated with renal transplant tolerance in humans

Newell, K. A., Asare, A., Kirk, A. D., Gisler, T. D., Bourcier, K., Suthanthiran, M., Burlingham, W. J., Marks, W. H., Sanz, I., Lechler, R. I., Hernandez-Fuentes, M. P., Turka, L. A. & Seyfert-Margolis, V. L., 1 Jun 2010, In : Journal of Clinical Investigation. 120, 6, p. 1836-1847 12 p.

Research output: Contribution to journalArticle

457 Citations (Scopus)

Urinary cell levels of mRNA for OX40, OX40L, PD-1, PD-L1, or PD-L2 and acute rejection of human renal allografts

Afaneh, C., Muthukumar, T., Lubetzky, M., Ding, R., Snopkowski, C., Sharma, V. K., Seshan, S., Dadhania, D., Schwartz, J. E. & Suthanthiran, M., 27 Dec 2010, In : Transplantation. 90, 12, p. 1381-1387 7 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Validation of noninvasive diagnosis of BK virus nephropathy and identification of prognostic biomarkers

Dadhania, D., Snopkowski, C., Ding, R., Muthukumar, T., Lee, J., Bang, H., Sharma, V. K., Seshan, S., August, P., Kapur, S. & Suthanthiran, M., 27 Jul 2010, In : Transplantation. 90, 2, p. 189-197 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2009

Circulating transforming growth factor-Β1 levels and the risk for kidney disease in African Americans

Suthanthiran, M., Gerber, L. M., Schwartz, J. E., Sharma, V. K., Medeiros, M., Marion, R., Pickering, T. G. & August, P., 1 Jul 2009, In : Kidney International. 76, 1, p. 72-80 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

MicroRNA expression profiles predictive of human renal allograft status

Anglicheau, D., Sharma, V. K., Ding, R., Hummel, A., Snopkowski, C., Dadhania, D., Seshan, S. V. & Suthanthiran, M., 31 Mar 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 13, p. 5330-5335 6 p.

Research output: Contribution to journalArticle

249 Citations (Scopus)

Post-transplantation malignancy: a cell autonomous mechanism with implications for therapy.

Suthanthiran, M., Hojo, M., Maluccio, M., Boffa, D. J. & Luan, F. L., 2009, In : Transactions of the American Clinical and Climatological Association. 120, p. 369-388 20 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Transforming growth factor beta and excess burden of renal disease.

August, P., Sharma, V., Ding, R., Schwartz, J. E. & Suthanthiran, M., 2009, In : Transactions of the American Clinical and Climatological Association. 120, p. 61-72 12 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)