Manikkam Suthanthiran

Professor

  • 12742 Citations
  • 53 h-Index
1977 …2020

Research output per year

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Research Output

2020

Separating the signal from the noise in metagenomic cell-free DNA sequencing

Burnham, P., Gomez-Lopez, N., Heyang, M., Cheng, A. P., Lenz, J. S., Dadhania, D. M., Lee, J. R., Suthanthiran, M., Romero, R. & De Vlaminck, I., 11 Feb 2020, In : Microbiome. 8, 1, 18.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Urinary cell transcriptomics and acute rejection in human kidney allografts

Verma, A., Muthukumar, T., Yang, H., Lubetzky, M., Cassidy, M. F., Lee, J. R., Dadhania, D. M., Snopkowski, C., Shankaranarayanan, D., Salvatore, S. P., Sharma, V. K., Xiang, J. Z., De Vlaminck, I., Seshan, S. V., Mueller, F. B., Suhre, K., Elemento, O. & Suthanthiran, M., 27 Feb 2020, In : JCI Insight. 5, 4, e131552.

Research output: Contribution to journalArticle

Open Access
2019

A cell-free DNA metagenomic sequencing assay that integrates the host injury response to infection

Cheng, A. P., Burnham, P., Lee, J. R., Cheng, M. P., Suthanthiran, M., Dadhania, D. & De Vlaminck, I., 10 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18738-18744 7 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Butyrate-producing gut bacteria and viral infections in kidney transplant recipients: A pilot study

Lee, J. R., Huang, J., Magruder, M., Zhang, L. T., Gong, C., Sholi, A. N., Albakry, S., Edusei, E., Muthukumar, T., Lubetzky, M., Dadhania, D. M., Taur, Y., Pamer, E. G. & Suthanthiran, M., 1 Dec 2019, In : Transplant Infectious Disease. 21, 6, e13180.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Gastrointestinal pathogen colonization and the microbiome in asymptomatic kidney transplant recipients

Westblade, L. F., Satlin, M. J., Albakry, S., Botticelli, B., Robertson, A., Alston, T., Magruder, M., Zhang, L. T., Edusei, E., Chan, K., Lubetzky, M., Dadhania, D. M., Pamer, E. G., Suthanthiran, M. & Lee, J. R., 1 Dec 2019, In : Transplant Infectious Disease. 21, 6, e13167.

Research output: Contribution to journalArticle

Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection

Magruder, M., Sholi, A. N., Gong, C., Zhang, L., Edusei, E., Huang, J., Albakry, S., Satlin, M. J., Westblade, L. F., Crawford, C., Dadhania, D. M., Lubetzky, M., Taur, Y., Littman, E., Ling, L., Burnham, P., De Vlaminck, I., Pamer, E., Suthanthiran, M. & Lee, J. R., 1 Dec 2019, In : Nature communications. 10, 1, 5521.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Landscape of innate immune system transcriptome and acute T cell–mediated rejection of human kidney allografts

Mueller, F. B., Yang, H., Lubetzky, M., Verma, A., Lee, J. R., Dadhania, D. M., Xiang, J. Z., Salvatore, S. P., Seshan, S. V., Sharma, V. K., Elemento, O., Suthanthiran, M. & Muthukumar, T., 11 Jul 2019, In : JCI Insight. 4, 13, :e128014.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2018

A tribute to Terry Strom

Turka, L. A. & Suthanthiran, M., 1 Mar 2018, In : The Journal of clinical investigation. 128, 3, p. 891-892 2 p.

Research output: Contribution to journalArticle

Open Access

Gut microbiota dysbiosis and diarrhea in kidney transplant recipients

Lee, J. R., Magruder, M., Zhang, L., Westblade, L. F., Satlin, M. J., Robertson, A., Edusei, E., Crawford, C., Ling, L., Taur, Y., Schluter, J., Lubetzky, M., Dadhania, D., Pamer, E. & Suthanthiran, M., 1 Jan 2018, (Accepted/In press) In : American Journal of Transplantation.

Research output: Contribution to journalArticle

10 Citations (Scopus)

MicroRNAs and Transplantation

Khan, Z., Suthanthiran, M. & Muthukumar, T., 1 Jan 2018, (Accepted/In press) In : Clinics in Laboratory Medicine.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Single nucleotide variant counts computed from RNA sequencing and cellular traffic into human kidney allografts

Thareja, G., Yang, H., Hayat, S., Mueller, F. B., Lee, J. R., Lubetzky, M., Dadhania, D. M., Belkadi, A., Seshan, S. V., Suhre, K., Suthanthiran, M. & Muthukumar, T., 1 Jan 2018, (Accepted/In press) In : American Journal of Transplantation.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract

Burnham, P., Dadhania, D., Heyang, M., Chen, F., Westblade, L. F., Suthanthiran, M., Lee, J. R. & De Vlaminck, I., 1 Dec 2018, In : Nature Communications. 9, 1, 2412.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Urine biomarkers informative of human kidney allograft rejection and tolerance

Nissaisorakarn, V., Lee, J. R., Lubetzky, M. & Suthanthiran, M., 1 Jan 2018, (Accepted/In press) In : Human Immunology.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Kidney allograft failure in the steroid-free immunosuppression era: A matched case-control study

Alkadi, M. M., Kim, J., Aull, M. J., Schwartz, J. E., Lee, J. R., Watkins, A., Lee, J. B., Dadhania, D. M., Seshan, S. V., Serur, D., Kapur, S., Suthanthiran, M., Hartono, C. & Muthukumar, T., 1 Nov 2017, In : Clinical Transplantation. 31, 11, e13117.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Sex and kidney transplantation: Why can't a woman be more like a man?

August, P. & Suthanthiran, M., 1 Oct 2017, In : Journal of the American Society of Nephrology. 28, 10, p. 2829-2831 3 p.

Research output: Contribution to journalEditorial

2016

Acute Rejection, Kidney Allograft Function, and Graft Survival in Patients with Circulating Pre-Transplant IgG Antibodies Directed Against Donor HLA-A, -B, or -C Locus Determined Antigens

Abuhelaiqa, E., Friedlander, R., Aull, M., Putheti, P., Sharma, V., Suthanthiran, M. & Dadhania, D., 1 Jan 2016, In : Clinical transplants. 32, p. 83-91 9 p.

Research output: Contribution to journalArticle

Exome Sequencing and Prediction of Long-Term Kidney Allograft Function

Mesnard, L., Muthukumar, T., Burbach, M., Li, C., Shang, H., Dadhania, D., Lee, J. R., Sharma, V. K., Xiang, J., Suberbielle, C., Carmagnat, M., Ouali, N., Rondeau, E., Friedewald, J. J., Abecassis, M. M., Suthanthiran, M. & Campagne, F., Sep 2016, In : PLoS Computational Biology. 12, 9, e1005088.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Urine metabolite profiles predictive of human kidney allograft status

Suhre, K., Schwartz, J. E., Sharma, V. K., Chen, Q., Lee, J. R., Muthukumar, T., Dadhania, D. M., DIng, R., Ikle, D. N., Bridges, N. D., Williams, N. M., Kastenmüller, G., Karoly, E. D., Mohney, R. P., Abecassis, M., Friedewald, J., Knechtle, S. J., Becker, Y. T., Samstein, B., Shaked, A. & 2 others, Gross, S. S. & Suthanthiran, M., 1 Feb 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 626-636 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2015

Biomarkers of allograft rejection and tolerance

Hartono, C., Muthukumar, T. & Suthanthiran, M., 12 Sep 2015, Transplant Immunology. Wiley Blackwell, p. 259-279 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Characteristics of circulating donor human leukocyte antigen-specific immunoglobulin G antibodies predictive of acute antibody-mediated rejection and kidney allograft failure

Kannabhiran, D., Lee, J., Schwartz, J. E., Friedlander, R., Aull, M., Muthukumar, T., Campbell, S., Epstein, D., Seshan, S. V., Kapur, S., Sharma, V. K., Suthanthiran, M. & Dadhania, D., 1 Jan 2015, In : Transplantation. 99, 6, p. 1156-1164 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Design and implementation of the international genetics and translational research in transplantation network

The International Genetics & Translational Research in Transplantation Network (iGeneTRAiN), 23 Oct 2015, In : Transplantation. 99, 11, p. 2401-2412 12 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Gut microbiota and tacrolimus dosing in kidney transplantation

Lee, J. R., Muthukumar, T., Dadhania, D., Taur, Y., Jenq, R. R., Toussaint, N. C., Ling, L., Pamer, E. & Suthanthiran, M., 27 Mar 2015, In : PLoS One. 10, 3, e0122399.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Urine CXCL10/IP-10 fingers ongoing antibody-mediated kidney graft rejection

Fairchild, R. L. & Suthanthiran, M., 1 Nov 2015, In : Journal of the American Society of Nephrology. 26, 11, p. 2607-2609 3 p.

Research output: Contribution to journalEditorial

5 Citations (Scopus)
2014

Allograft rejection and tubulointerstitial fibrosis in human kidney allografts: Interrogation by urinary cell mRNA profiling

Muthukumar, T., Lee, J. R., Dadhania, D. M., Ding, R., Sharma, V. K., Schwartz, J. E. & Suthanthiran, M., Jul 2014, In : Transplantation Reviews. 28, 3, p. 145-154 10 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Circulating levels of 25-hydroxyvitamin D and acute cellular rejection in kidney allograft recipients

Lee, J. R., Dadhania, D., August, P., Lee, J. B., Suthanthiran, M. & Muthukumar, T., 15 Aug 2014, In : Transplantation. 98, 3, p. 292-299 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Gut microbial community structure and complications after kidney transplantation: A pilot study

Lee, J. R., Muthukumar, T., Dadhania, D., Toussaint, N. C., Ling, L., Pamer, E. & Suthanthiran, M., 15 Oct 2014, In : Transplantation. 98, 7, p. 697-705 9 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Hypertension, kidney disease, HIV and antiretroviral therapy among Tanzanian adults: A cross-sectional study

Peck, R. N., Shedafa, R., Kalluvya, S., Downs, J. A., Todd, J., Suthanthiran, M., Fitzgerald, D. W. & Kataraihya, J. B., 29 Jul 2014, In : BMC Medicine. 12, 1, 125.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Urinary cell mRNA profiles and differential diagnosis of acute kidney graft dysfunction

Matignon, M., Ding, R., Dadhania, D. M., Mueller, F. B., Hartono, C., Snopkowski, C., Li, C., Lee, J. R., Sjoberg, D., Seshan, S. V., Sharma, V. K., Yang, H., Nour, B., Vickers, A. J., Suthanthiran, M. & Muthukumar, T., 1 Jul 2014, In : Journal of the American Society of Nephrology. 25, 7, p. 1586-1597 12 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Urinary cell mRNA profiles predictive of human kidney allograft status

Lee, J. R., Muthukumar, T., Dadhania, D., Ding, R., Sharma, V. K., Schwartz, J. E. & Suthanthiran, M., Mar 2014, In : Immunological Reviews. 258, 1, p. 218-240 23 p.

Research output: Contribution to journalReview article

25 Citations (Scopus)
2013

Genomic biomarkers correlate with HLA-identical renal transplant tolerance

Leventhal, J. R., Mathew, J. M., Salomon, D. R., Kurian, S. M., Suthanthiran, M., Tambur, A., Friedewald, J., Gallon, L., Charette, J., Levitsky, J., Kanwar, Y., Abecassis, M. & Miller, J., 1 Sep 2013, In : Journal of the American Society of Nephrology. 24, 9, p. 1376-1385 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

HIV-infected kidney graft recipients managed with an early corticosteroid withdrawal protocol: Clinical outcomes and messenger RNA profiles

Muthukumar, T., Afaneh, C., Ding, R., Tsapepas, D., Lubetzky, M., Jacobs, S., Lee, J., Sharma, V., Lee, J., Dadhania, D., Hartono, C., McDermott, J., Aull, M., Leeser, D., Kapur, S., Serur, D. & Suthanthiran, M., 15 Mar 2013, In : Transplantation. 95, 5, p. 711-720 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

HLA identical non-chimeric and HLA disparate chimeric renal transplant tolerance.

Leventhal, J. R., Mathew, J. M., Ildstad, S., Salomon, D. R., Kurian, S. M., Suthanthiran, M., Tambur, A., Friedewald, J., Gallon, L., Charette, J., Levitsky, J., Kanwar, Y., Abecassis, M. & Miller, J., 1 Jan 2013, In : Clinical transplants. p. 145-156 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Immunosuppressive drug therapy

Hartono, C., Muthukumar, T. & Suthanthiran, M., 17 Sep 2013, In : Cold Spring Harbor Perspectives in Medicine. 3, 9

Research output: Contribution to journalArticle

36 Citations (Scopus)

Independent risk factors for urinary tract infection and for subsequent bacteremia or acute cellular rejection: A single-center report of 1166 kidney allograft recipients

Lee, J. R., Bang, H., Dadhania, D., Hartono, C., Aull, M. J., Satlin, M., August, P., Suthanthiran, M. & Muthukumar, T., 27 Oct 2013, In : Transplantation. 96, 8, p. 732-738 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling

Keslar, K. S., Lin, M., Zmijewska, A. A., Sigdel, T. K., Tran, T. Q., Ma, L., Bhasin, M., Rao, P., Ding, R., Iklé, D. N., Mannon, R. B., Sarwal, M. M., Strom, T. B., Reed, E. F., Heeger, P. S., Suthanthiran, M. & Fairchild, R. L., 1 Jul 2013, In : American Journal of Transplantation. 13, 7, p. 1891-1897 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Noninvasive prognostication of polyomavirus BK virus-associated nephropathy

Dadhania, D., Snopkowski, C., Muthukumar, T., Lee, J., Ding, R., Sharma, V. K., Christos, P., Bang, H., Kapur, S., Seshan, S. V. & Suthanthiran, M., 27 Jul 2013, In : Transplantation. 96, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

On the detection of anti-HLA antibodies using single antigen bead luminex assay: Lot-to-lot variations in MFI

Friedlander, R., Putheti, P., Diaz, E., Menon, A., Ponce, B., Muthukumar, T., Sharma, V. K., Dadhania, D. & Suthanthiran, M., 27 Aug 2013, In : Transplantation. 96, 4, p. e24-e26

Research output: Contribution to journalLetter

13 Citations (Scopus)

The authors reply

Suthanthiran, M., Muthukumar, T. & Schwartz, J. E., 11 Nov 2013, In : New England Journal of Medicine. 369, 19, p. 1860-1861 2 p.

Research output: Contribution to journalLetter

14 Citations (Scopus)

The Nobel Prize-winning work of Ralph Steinman (1943-2011) and its relevance to transplantation.

Thomson, A. W. & Suthanthiran, M., 1 Jan 2013, In : Transplantation. 95, 1, p. 15-16 2 p.

Research output: Contribution to journalEditorial

Urinary-cell mRNA profile and acute cellular rejection in kidney allografts

Suthanthiran, M., Schwartz, J. E., Ding, R., Abecassis, M., Dadhania, D., Samstein, B., Knechtle, S. J., Friedewald, J., Becker, Y. T., Sharma, V. K., Williams, N. M., Chang, C. S., Hoang, C., Muthukumar, T., August, P., Keslar, K. S., Fairchild, R. L., Hricik, D. E., Heeger, P. S., Han, L. & 5 others, Liu, J., Riggs, M., Ikle, D. N., Bridges, N. D. & Shaked, A., 1 Jan 2013, In : New England Journal of Medicine. 369, 1, p. 20-31 12 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Urinary-cell MRNA profile and acute cellular rejection in kidney allografts

Suthanthiran, M., Schwartz, J. E., Ding, R., Abecassis, M., Dadhania, D., Samstein, B., Knechtle, S. J., Friedewald, J., Becker, Y. T., Sharma, V. K., Williams, N. M., Chang, C. S., Hoang, C., Muthukumar, T., August, P., Keslar, K. S., Fairchild, R. L., Hricik, D. E., Heeger, P. S., Han, L. & 5 others, Liu, J., Riggs, M., Ikle, D. N., Bridges, N. D. & Shaked, A., Dec 2013, In : Journal of Urology. 190, 6, p. 2175-2176 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2012

Angiogenic factors in superimposed preeclampsia: A longitudinal study of women with chronic hypertension during pregnancy

Perni, U., Sison, C., Sharma, V., Helseth, G., Hawfield, A., Suthanthiran, M. & August, P., 1 Mar 2012, In : Hypertension. 59, 3, p. 740-746 7 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Concurrent acute cellular rejection is an independent risk factor for renal allograft failure in patients with C4d-positive antibody-mediated rejection

Matignon, M., Muthukumar, T., Seshan, S. V., Suthanthiran, M. & Hartono, C., 27 Sep 2012, In : Transplantation. 94, 6, p. 603-611 9 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Dendritic cells with TGF-β1 and IL-2 differentiate naive CD4+ T Cells into alloantigen-specific and allograft protective foxp3+ regulatory T cells

Yang, H., Cheng, E. Y., Sharma, V. K., Lagman, M., Chang, C., Song, P., Ding, R., Muthukumar, T. & Suthanthiran, M., 27 Mar 2012, In : Transplantation. 93, 6, p. 580-588 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Discovery and validation of a molecular signature for the noninvasive diagnosis of human renal allograft fibrosis

Anglicheau, D., Muthukumar, T., Hummel, A., Ding, R., Sharma, V. K., Dadhania, D., Seshan, S. V., Schwartz, J. E. & Suthanthiran, M., 15 Jun 2012, In : Transplantation. 93, 11, p. 1136-1146 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Early corticosteroid withdrawal in recipients of renal allografts: A single-center report of ethnically diverse recipients and recipients of marginal deceased-donor kidneys

Aull, M. J., Dadhania, D., Afaneh, C., Leeser, D. B., Hartono, C., Lee, J. B., Serur, D., Del Pizzo, J. J., Suthanthiran, M. & Kapur, S., 27 Oct 2012, In : Transplantation. 94, 8, p. 837-844 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Excretion of anti-angiogenic proteins in patients with chronic allograft dysfunction

Moskowitz-Kassai, E., MacKelaite, L., Chen, J., Patel, K., Dadhania, D. M., Gross, S. S., Chander, P., Delaney, V., Deng, L., Chen, L., Cui, X., Suthanthiran, M. & Goligorsky, M. S., 1 Feb 2012, In : Nephrology Dialysis Transplantation. 27, 2, p. 494-497 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mean arterial blood pressure while awaiting kidney transplantation is associated with the risk of primary nonfunction

Webber, A., Hambleton, J., Chami, A., Bang, H., Seshan, S., Sharma, A., August, P., Kapur, S., Suthanthiran, M. & Dadhania, D., 15 Jan 2012, In : Transplantation. 93, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

MicroRNA sequence profiles of human kidney allografts with or without tubulointerstitial fibrosis

Ben-Dov, I. Z., Muthukumar, T., Morozov, P., Mueller, F. B., Tuschl, T. & Suthanthiran, M., 15 Dec 2012, In : Transplantation. 94, 11, p. 1086-1094 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)
2010

Banff '09 meeting report: Antibody mediated graft deterioration and implementation of Banff working groups

Sis, B., Mengel, M., Haas, M., Colvin, R. B., Halloran, P. F., Racusen, L. C., Solez, K., Baldwin, W. M., Bracamonte, E. R., Broecker, V., Cosio, F., Demetris, A. J., Drachenberg, C., Einecke, G., Gloor, J., Glotz, D., Kraus, E., Legendre, C., Liapis, H., Mannon, R. B. & 13 others, Nankivell, B. J., Nickeleit, V., Papadimitriou, J. C., Randhawa, P., Regele, H., Renaudin, K., Rodriguez, E. R., Seron, D., Seshan, S., Suthanthiran, M., Wasowska, B. A., Zachary, A. & Zeevi, A., Mar 2010, In : American Journal of Transplantation. 10, 3, p. 464-471 8 p.

Research output: Contribution to journalArticle

574 Citations (Scopus)