• 704 Citations
  • 8 h-Index
20112019
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Research Output 2011 2019

  • 704 Citations
  • 8 h-Index
  • 17 Article
  • 1 Comment/debate
  • 1 Review article
2019
1 Citation (Scopus)

Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts

Pasquier, J., Spurgeon, M., Bradic, M., Thomas, B., Robay, A., Chidiac, O., DIb, M. J., Turjoman, R., Liberska, A., Staudt, M., Fakhro, K. A. M. A., Menzies, R., Jayyousi, A., Zirie, M., Suwaidi, J. A., Malik, R., Talal, T., Tabrizi, A. R., Mezey, J., Rodriguez-Flores, J. & 2 others, Crystal, R. & Abi Khalil, C., 1 Feb 2019, In : Epigenomics. 11, 3, p. 281-296 16 p.

Research output: Contribution to journalArticle

Diabetic Foot
Osteoclasts
Monocytes
Type 2 Diabetes Mellitus
Foot
2018
4 Citations (Scopus)

A systematic review on the genetics of male infertility in the era of next-generation sequencing

Robay, A., Abbasi, S., Akil, A., El-Bardisi, H., Arafa, M., Crystal, R. & Fakhro, K. A. M. A., 1 Mar 2018, In : Arab Journal of Urology. 16, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

Male Infertility
Exome
Oligospermia
Azoospermia
Technology
1 Citation (Scopus)

Differentially expressed circulating microRNAs in the development of acute diabetic Charcot foot

Pasquier, J., Ramachandran, V., Abu-Qaoud, MD. R., Thomas, B., Benurwar, M. J., Chidiac, O., Hoarau, J., Robay, A., Fakhro, K. A. M. A., Menzies, R. A., Jayyousi, A., Zirie, M., Al Suwaidi, J., Malik, R., Talal, T. K., Najafi, H., Tabrizi, A. R. & Abi Khalil, C., 1 Oct 2018, In : Epigenomics. 10, 10, p. 1267-1278 12 p.

Research output: Contribution to journalArticle

Diabetic Foot
MicroRNAs
Type 2 Diabetes Mellitus
Foot

Exome sequencing-based identification of novel type 2 diabetes risk allele loci in the Qatari population

O’Beirne, S. L., Salit, J., Rodriguez-Flores, J. L., Staudt, M. R., Abi Khalil, C., Fakhro, K. A. M. A., Robay, A., Ramstetter, M. D., Malek, J., Zirie, M., Jayyousi, A., Badii, R., Al-Marri, A. A. N., Bener, A., Mahmoud, M., Chiuchiolo, M. J., Al-Shakaki, A., Chidiac, O., Stadler, D., Mezey, J. G. & 1 others, Crystal, R., 1 Sep 2018, In : PLoS One. 13, 9, e0199837.

Research output: Contribution to journalArticle

Exome
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Alleles

Hypertrophic cardiomyopathy-linked variants of cardiac myosin-binding protein C3 display altered molecular properties and actin interaction

Da'as, S., Fakhro, K. A. M. A., Thanassoulas, A., Krishnamoorthy, N., Saleh, A., Calver, B. L., Safieh-Garabedian, B., Toft, E., Nounesis, G., Anthony Lai, F. & Nomikos, M., 14 Dec 2018, In : Biochemical Journal. 475, 24, p. 3933-3948 16 p.

Research output: Contribution to journalArticle

Cardiac Myosins
Hypertrophic Cardiomyopathy
Actins
Carrier Proteins
Display devices
2 Citations (Scopus)

Point-of-care whole-exome sequencing of idiopathic male infertility

Fakhro, K. A. M. A., Elbardisi, H., Arafa, M., Robay, A., Rodriguez-Flores, J. L., Al-Shakaki, A., Syed, N., Mezey, J. G., Abi Khalil, C., Malek, J., Al-Ansari, A., Al Said, S. & Crystal, R., 1 Nov 2018, In : Genetics in Medicine. 20, 11, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Exome
Male Infertility
Genes
Middle East
8 Citations (Scopus)
Exome
sequencing
Quantitative Trait Loci
loci
Metabolites
2017
6 Citations (Scopus)
Diabetic Foot
Osteoclasts
Foot
Monocytes
Cytokines
2016

Correction: Type 2 diabetes risk allele loci in the Qatari population (PLoS ONE (2016) 11:7 (e0156834) DOI: 10.1371/journal.pone.0156834)

O'Beirne, S. L., Salit, J., Rodriguez-Flores, J. L., Staudt, M. R., Abi Khalil, C., Fakhro, K. A. M. A., Robay, A., Ramstetter, M. D., Al Azwani, I., Malek, J., Zirie, M., Jayyousi, A., Badii, R., Al-Marri, A. A. N., Chiuchiolo, M. J., Al-Shakaki, A., Chidiac, O., Gharbiah, M., Bener, A., Stadler, D. & 3 others, Hackett, N. R., Mezey, J. G. & Crystal, R., 1 Aug 2016, In : PLoS One. 11, 8, e0161910.

Research output: Contribution to journalComment/debate

e-mail
Electronic mail
Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
31 Citations (Scopus)

Indigenous Arabs are descendants of the earliest split from ancient Eurasian populations

Rodriguez-Flores, J. L., Fakhro, K. A. M. A., Agosto-Perez, F., Ramstetter, M. D., Arbiza, L., Vincent, T. L., Robay, A., Malek, J., Suhre, K., Chouchane, L., Badii, R., Al-Marri, A. A. N., Abi Khalil, C., Zirie, M., Jayyousi, A., Salit, J., Keinan, A., Clark, A. G., Crystal, R. & Mezey, J. G., 1 Feb 2016, In : Genome Research. 26, 2, p. 151-162 12 p.

Research output: Contribution to journalArticle

Neanderthals
Genome
Population
Emigration and Immigration
Population Groups
25 Citations (Scopus)

The Qatar genome: A population-specific tool for precision medicine in the Middle East

Fakhro, K. A. M. A., Staudt, M. R., Ramstetter, M. D., Robay, A., Malek, J., Badii, R., Al-Marri, A. A. N., Abi Khalil, C., Al-Shakaki, A., Chidiac, O., Stadler, D., Zirie, M., Jayyousi, A., Salit, J., Mezey, J. G., Crystal, R. & Rodriguez-Flores, J. L., 30 Jun 2016, In : Human Genome Variation. 3, 16016.

Research output: Contribution to journalArticle

Open Access
Qatar
Precision Medicine
Middle East
Medicine
Genes
8 Citations (Scopus)
Ligases
Genome
Phenotype
Vesico-Ureteral Reflux
Mutation
8 Citations (Scopus)

Type 2 diabetes risk allele loci in the Qatari population

O'Beirne, S. L., Salit, J., Rodriguez-Flores, J. L., Staudt, M. R., Abi Khalil, C., Fakhro, K. A. M. A., Robay, A., Ramstetter, M. D., Al Azwani, I., Malek, J., Zirie, M., Jayyousi, A., Badii, R., Al-Nabet Al-marri, A., Chiuchiolo, M. J., Al-Shakaki, A., Chidiac, O., Gharbiah, M., Bener, A., Stadler, D. & 3 others, Hackett, N. R., Mezey, J. G. & Crystal, R., 1 Jul 2016, In : PLoS One. 11, 7, e0156834.

Research output: Contribution to journalArticle

Medical problems
noninsulin-dependent diabetes mellitus
Type 2 Diabetes Mellitus
Alleles
Polymorphism
2015
3 Citations (Scopus)

Copy number variations in the genome of the Qatari population

Fakhro, K. A. M. A., Yousri, N., Rodriguez-Flores, J. L., Robay, A., Staudt, M. R., Agosto-Perez, F., Salit, J., Malek, J., Suhre, K., Jayyousi, A., Zirie, M., Stadler, D., Mezey, J. G. & Crystal, R., 22 Oct 2015, In : BMC Genomics. 16, 1, 834.

Research output: Contribution to journalArticle

Genome
Population
Single Nucleotide Polymorphism
Chromosome Disorders
Databases
17 Citations (Scopus)

Epigenetics and Cardiovascular Disease in Diabetes

Pasquier, J., Hoarau, J., Fakhro, K. A. M. A., Tabrizi, A. R. & Abi Khalil, C., 1 Dec 2015, In : Current Diabetes Reports. 15, 12, 108.

Research output: Contribution to journalReview article

Epigenomics
Cardiovascular Diseases
Hyperglycemia
Blood Vessels
Long Noncoding RNA
6 Citations (Scopus)

Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population

Upadhyay, R., Robay, A., Fakhro, K. A. M. A., Khalil, A. A., Zirie, M., Jayyousi, A., El-Shafei, M., Kiss, S., D'Amico, D. J., Salit, J., Staudt, M. R., O'Beirne, S. L., Chen, X., Tuana, B., Crystal, R. & Ding, H., 15 Feb 2015, In : Journal of Translational Medicine. 13, 1, 61.

Research output: Contribution to journalArticle

Diabetic Retinopathy
Medical problems
Polymorphism
Genes
Population
2014
28 Citations (Scopus)

Exome Sequencing Identifies Potential Risk Variants for Mendelian Disorders at High Prevalence in Qatar

Rodriguez-Flores, J. L., Fakhro, K., Hackett, N. R., Salit, J., Fuller, J., Agosto-Perez, F., Gharbiah, M., Malek, J. A., Zirie, M., Jayyousi, A., Badii, R., Al-Nabet Al-Marri, A., Chouchane, L., Stadler, D. J., Mezey, J. G. & Crystal, R. G., Jan 2014, In : Human Mutation. 35, 1, p. 105-116 12 p.

Research output: Contribution to journalArticle

Qatar
Exome
Population
Genome
Penetrance
2013
424 Citations (Scopus)

De novo mutations in histone-modifying genes in congenital heart disease

Zaidi, S., Choi, M., Wakimoto, H., Ma, L., Jiang, J., Overton, J. D., Romano-Adesman, A., Bjornson, R. D., Breitbart, R. E., Brown, K. K., Carriero, N. J., Cheung, Y. H., Deanfield, J., Depalma, S., Fakhro, K. A. M. A., Glessner, J., Hakonarson, H., Italia, M. J., Kaltman, J. R., Kaski, J. & 30 others, Kim, R., Kline, J. K., Lee, T., Leipzig, J., Lopez, A., Mane, S. M., Mitchell, L. E., Newburger, J. W., Parfenov, M., Pe'Er, I., Porter, G., Roberts, A. E., Sachidanandam, R., Sanders, S. J., Seiden, H. S., State, M. W., Subramanian, S., Tikhonova, I. R., Wang, W., Warburton, D., White, P. S., Williams, I. A., Zhao, H., Seidman, J. G., Brueckner, M., Chung, W. K., Gelb, B. D., Goldmuntz, E., Seidman, C. E. & Lifton, R. P., 2013, In : Nature. 498, 7453, p. 220-223 4 p.

Research output: Contribution to journalArticle

Histones
Heart Diseases
Methylation
Mutation
Genes
2011
132 Citations (Scopus)

Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning

Fakhro, K. A. M. A., Choi, M., Ware, S. M., Belmont, J. W., Towbin, J. A., Lifton, R. P., Khokha, M. K. & Brueckner, M., 15 Feb 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2915-2920 6 p.

Research output: Contribution to journalArticle

Heart Diseases
Genes
Xenopus
Body Patterning
Genetic Fitness