• 1755 Citations
  • 25 h-Index
1992 …2019

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Article
2019

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. L. & Trebak, M., 19 Apr 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

miRNA-dependent regulation of STIM1 expression in breast cancer

Kulkarni, R. P., Elmi, A., Alcantara-Adap, E., Hubrack, S. Z., Nader, N., Yu, F., Dib, M., Ramachandran, V., Najafi Shoushtari, H. & Machaca, K., 10 Sep 2019, In : Scientific reports. 9, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis

Yu, F., Hubrack, S. Z., Chakraborty, S., Sun, L., Alcantara-Adap, E., Kulkarni, R., Billing, A., Graumann, J., Taylor, C. W. & Machaca, K., 1 Jan 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 21, p. 10392-10401 10 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Synthesis of TPEN variants to improve cancer cells selective killing capacity

Schaefer-Ramadan, S., Barlog, M., Roach, J., Al-Hashimi, M., Bazzi, H. S. & Machaca, K., Jun 2019, In : Bioorganic Chemistry. 87, p. 366-372 7 p.

Research output: Contribution to journalArticle

2018
1 Citation (Scopus)

The CCT chaperonin is a novel regulator of Ca2+ signaling through modulation of Orai1 trafficking

Hodeify, R., Nandakumar, M., Own, M., Courjaret, R. J., Graumann, J., Hubrack, S. Z. & Machaca, K., 26 Sep 2018, In : Science advances. 4, 9, aau1935.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The VLDL receptor regulates membrane progesterone receptor trafficking and non-genomic signaling

Nader, N., Dib, M., Courjaret, R. J., Hodeify, R., Machaca, R., Graumann, J. & Machaca, K., 15 May 2018, In : Journal of Cell Science. 131, 10, jcs212522.

Research output: Contribution to journalArticle

1 Citation (Scopus)
1 Citation (Scopus)
2017

Coculturing with endothelial cells promotes in vitro maturation and electrical coupling of human embryonic stem cell–derived cardiomyocytes

Pasquier, J., Gupta, R., Rioult, D., Hoarau-Véchot, J., Courjaret, R., Machaca, K., Al Suwaidi, J., Stanley, E. G., Rafii, S., Elliott, D. A., Abi Khalil, C. & Rafii, A., Jun 2017, In : Journal of Heart and Lung Transplantation. 36, 6, p. 684-693 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Effects of Hyperglycemia on Vascular Smooth Muscle Ca2+ Signaling

El-Najjar, N., Kulkarni, R. P., Nader, N., Hodeify, R. & Machaca, K., 21 Jun 2017, In : BioMed Research International. 2017, 3691349.

Research output: Contribution to journalArticle

4 Citations (Scopus)
8 Citations (Scopus)
2016

A novel approach to the expression and purification of recombinant Xenopus Cdc25C

Ramadan, S., Bendriss, G., Hubrack, S. Z., Al-Abdulmalek, A. & Machaca, K., 1 Apr 2016, In : Protein Expression and Purification. 120, p. 148-152 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells

Rahal, O. N., Fatfat, M., Hankache, C., Osman, B., Khalife, H., Machaca, K. & Muhtasib, H. G., 1 Nov 2016, In : Cancer Biology and Therapy. 17, 11, p. 1139-1148 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Release from Xenopus oocyte prophase I meiotic arrest is independent of a decrease in cAMP levels or PKA activity

Nader, N., Courjaret, R., Dib, M., Kulkarni, R. P. & Machaca, K., 1 Jun 2016, In : Development (Cambridge). 143, 11, p. 1926-1936 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
8 Citations (Scopus)
Open Access
3 Citations (Scopus)
2015

A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca2+ influx levels

Hodeify, R., Selvaraj, S., Wen, J., Arredouani, A., Hubrack, S., Dib, M., Al-Thani, S. N., McGraw, T. & Machaca, K., 1 Aug 2015, In : Journal of Cell Science. 128, 16, p. 3143-3154 12 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

The role of flexible loops in folding, trafficking and activity of equilibrative nucleoside transporters

Aseervatham, J., Tran, L., Machaca, K. & Boudker, O., 25 Sep 2015, In : PLoS One. 10, 9, e0136779.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

Fatfat, M., Merhi, R. A., Rahal, O., Stoyanovsky, D. A., Zaki, A., Haidar, H., Kagan, V. E., Gali-Muhtasib, H. & Machaca, K., 21 Jul 2014, In : BMC Cancer. 14, 1, 527.

Research output: Contribution to journalArticle

45 Citations (Scopus)
31 Citations (Scopus)

Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest

Nader, N., Dib, M., Daalis, A., Kulkarni, R. P. & Machaca, K., 15 Nov 2014, In : Developmental Biology. 395, 2, p. 355-366 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2013

Downregulation of store-operated Ca2+ entry during mammalian meiosis is required for the egg-to-embryo transition

Lee, B., Palermo, G. & Machaca, K., 1 Apr 2013, In : Journal of Cell Science. 126, 7, p. 1672-1681 10 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

How to make a good egg!. The need for remodeling of oocyte Ca2+ signaling to mediate the egg-to-embryo transition

Nader, N., Kulkarni, R. P., Dib, M. & Machaca, K., Jan 2013, In : Cell calcium. 53, 1, p. 41-54 14 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility

Abou-Saleh, H., Pathan, A. R., Daalis, A., Hubrack, S., Abou-Jassoum, H., Al-Naeimi, H., Rusch, N. J. & Machaca, K., 15 Nov 2013, In : Journal of Biological Chemistry. 288, 46, p. 32941-32951 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Intramolecular shielding maintains the ER Ca2+ sensor stim1 in an inactive conformation

Yu, F., Sun, L., Hubrack, S., Selvaraj, S. & Machaca, K., 1 Jun 2013, In : Journal of Cell Science. 126, 11, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffness

Chaston, D. J., Baillie, B. K., Grayson, T. H., Courjaret, R. J., Heisler, J. M., Lau, K. A., MacHaca, K., Nicholson, B. J., Ashton, A., Matthaei, K. I. & Hill, C. E., 1 May 2013, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 5, p. 962-970 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

The Xenopus TRPV6 homolog encodes a Mg2+-permeant channel that is inhibited by interaction with TRPC1

Courjaret, R., Hubrack, S., Daalis, A., Dib, M. & Machaca, K., 1 Dec 2013, In : Journal of Cellular Physiology. 228, 12, p. 2386-2398 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2012

Phosphorylation of the rat Ins(1,4,5)P3 receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P3

Haun, S., Sun, L., Hubrack, S., Yule, D. & MacHaca, K., 1 Jan 2012, In : Channels. 6, 5, p. 379-384 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

STIM and Orai in cellular proliferation and division

Courjaret, R. & Machaca, K., 1 Jan 2012, In : Frontiers in Bioscience - Elite. 4 E, 1, p. 331-341 11 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2011

Endoplasmic reticulum remodeling tunes IP3-dependent Ca2+ release sensitivity

Sun, L., Yu, F., Ullah, A., Hubrack, S., Daalis, A., Jung, P. & Machaca, K., 30 Nov 2011, In : PloS one. 6, 11, e27928.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Role of the STIM1 C-terminal domain in STIM1 clustering

Yu, F., Sun, L., Courjaret, R. & Machaca, K., 11 Mar 2011, In : Journal of Biological Chemistry. 286, 10, p. 8375-8384 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2010

Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis

Yu, F., Sun, L. & Machaca, K., 1 Nov 2010, In : Journal of Cell Biology. 191, 3, p. 523-535 13 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
2009

Kinase-dependent regulation of inositol 1,4,5-trisphosphate-dependent Ca2+ release during oocyte maturation

Sun, L., Haun, S., Jones, R. C., Edmondson, R. D. & Machaca, K., 24 Jul 2009, In : Journal of Biological Chemistry. 284, 30, p. 20184-20196 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
92 Citations (Scopus)
2008

Ca2+ homeostasis regulates Xenopus oocyte maturation

Sun, L., Hodeify, R., Haun, S., Charlesworth, A., MacNicol, A. M., Ponnappan, S., Ponnappan, U., Prigent, C. & Machaca, K., 1 Apr 2008, In : Biology of Reproduction. 78, 4, p. 726-735 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Internalization of plasma membrane Ca2+-ATPase during Xenopus oocyte maturation

El-Jouni, W., Haun, S. & Machaca, K., 1 Dec 2008, In : Developmental Biology. 324, 1, p. 99-107 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2007

Modeling Ca2+ signaling differentiation during oocyte maturation

Ullah, G., Jung, P. & Machaca, K., Dec 2007, In : Cell calcium. 42, 6, p. 556-564 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Vesicular traffic at the cell membrane regulates oocyte meiotic arrest

El-Jouni, W., Haun, S., Hodeify, R., Walker, A. H. & Machaca, K., 1 Sep 2007, In : Development. 134, 18, p. 3307-3315 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Zinc regulates the ability of Cdc25C to activate MPF/cdk1

Sun, L., Chai, Y., Hannigan, R., Bhogaraju, V. K. & Machaca, K., 1 Oct 2007, In : Journal of Cellular Physiology. 213, 1, p. 98-104 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2005

Calcium signaling differentiation during Xenopus oocyte maturation

El-Jouni, W., Jang, B., Haun, S. & Machaca, K., 15 Dec 2005, In : Developmental Biology. 288, 2, p. 514-525 12 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Rabphilin localizes with the cell actin cytoskeleton and stimulates association of granules with F-actin cross-linked by α-actinin

Baldini, G., Martelli, A. M., Tabellini, G., Horn, C., Machaca, K., Narducci, P. & Baldini, G., 14 Oct 2005, In : Journal of Biological Chemistry. 280, 41, p. 34974-34984 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

RNA interference is an antiviral defence mechanism in Caenorhabditis elegans

Wilkins, C., Dishongh, R., Moore, S. C., Whitt, M. A., Chow, M. & Machaca, K., 18 Aug 2005, In : Nature. 436, 7053, p. 1044-1047 4 p.

Research output: Contribution to journalArticle

234 Citations (Scopus)
2004

Ca2+cyt negatively regulates the initiation of oocyte maturation

Sun, L. & Machaca, K., 12 Apr 2004, In : Journal of Cell Biology. 165, 1, p. 63-75 13 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Increased sensitivity and clustering of elementary Ca2+ release events during oocyte maturation

Machaca, K., 1 Nov 2004, In : Developmental Biology. 275, 1, p. 170-182 13 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2003

Ca2+-Calmodulin-dependent Protein Kinase II Potentiates Store-operated Ca2+ Current

Machaca, K., 5 Sep 2003, In : Journal of Biological Chemistry. 278, 36, p. 33730-33737 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2002

Endoplasmic reticulum Ca2+ signaling and calpains mediate renal cell death

Harriman, J. F., Liu, X. L., Aleo, M. D., Machaca, K. & Schnellmann, R. G., 1 Jan 2002, In : Cell death and differentiation. 9, 7, p. 734-741 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
77 Citations (Scopus)
2000

Store-operated calcium entry inactivates at the germinal vesicle breakdown stage of Xenopus meiosis

Machaca, K. & Haun, S., 8 Dec 2000, In : Journal of Biological Chemistry. 275, 49, p. 38710-38715 6 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
1999
20 Citations (Scopus)

Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents

Machaca, K. & Hartzell, H. C., Feb 1999, In : Journal of General Physiology. 113, 2, p. 249-266 18 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)