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Research Output 1992 2019

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2019

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

Emrich, S. M., Yoast, R. E., Xin, P., Zhang, X., Pathak, T., Nwokonko, R., Gueguinou, M. F., Subedi, K. P., Zhou, Y., Ambudkar, I. S., Hempel, N., Machaca, K., Gill, D. L. & Trebak, M., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 16, p. 6318-6332 15 p.

Research output: Contribution to journalArticle

Molecules
Chemical activation
Clustered Regularly Interspaced Short Palindromic Repeats
Cell Membrane
Stromal Interaction Molecule 2

Synthesis of TPEN variants to improve cancer cells selective killing capacity

Ramadan, S., Barlog, M., Roach, J., Al-Hashimi, M., Bazzi, H. S. & Machaca, K., 1 Jun 2019, In : Bioorganic Chemistry. 87, p. 366-372 7 p.

Research output: Contribution to journalArticle

Copper
Chelating Agents
Cells
Toxicity
Metals
2018
1 Citation (Scopus)
Calcium
HeLa Cells
Inositol 1,4,5-Trisphosphate Receptors
Acinar Cells
Mitochondria

The CCT chaperonin is a novel regulator of Ca2+ signaling through modulation of Orai1 trafficking

Hodeify, R., Nandakumar, M., Own, M., Courjaret, R. J., Graumann, J., Hubrack, S. Z. & Machaca, K., 26 Sep 2018, In : Science advances. 4, 9, aau1935.

Research output: Contribution to journalArticle

Chaperonin Containing TCP-1
Recycling
Cell Membrane
Chaperonins
NFATC Transcription Factors

The VLDL receptor regulates membrane progesterone receptor trafficking and non-genomic signaling

Nader, N., Dib, M., Courjaret, R. J., Hodeify, R., Machaca, R., Graumann, J. & Machaca, K., 15 May 2018, In : Journal of Cell Science. 131, 10, jcs212522.

Research output: Contribution to journalArticle

Progesterone Receptors
Progesterone
Membranes
Cytoplasmic and Nuclear Receptors
Endoplasmic Reticulum
1 Citation (Scopus)
Signal transduction
Meiosis
Oocytes
Transition metals
Signal Transduction
2017
11 Citations (Scopus)
Endoplasmic Reticulum
Calcium-Binding Proteins
Acinar Cells
Extracellular Fluid
Cytosol
7 Citations (Scopus)

Coculturing with endothelial cells promotes in vitro maturation and electrical coupling of human embryonic stem cell-derived cardiomyocytes

Pasquier, J., Gupta, R., Rioult, D., Hoarau, J., Courjaret, R. J., Machaca, K., Al Suwaidi, J., Stanley, E. G., Rafii, S., Elliott, D. A., Abi Khalil, C. & Tabrizi, A. R., 2017, (Accepted/In press) In : Journal of Heart and Lung Transplantation.

Research output: Contribution to journalArticle

Cardiac Myocytes
Endothelial Cells
Coculture Techniques
Green Fluorescent Proteins
In Vitro Techniques
1 Citation (Scopus)

Effects of Hyperglycemia on Vascular Smooth Muscle Ca2+ Signaling

El-Najjar, N., Kulkarni, R. P., Nader, N., Hodeify, R. & Machaca, K., 21 Jun 2017, In : BioMed Research International. 2017, 3691349.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Hyperglycemia
Muscle
Pathology
Medical problems
7 Citations (Scopus)
Endoplasmic Reticulum
Oocytes
Chemical activation
Membranes
Inositol 1,4,5-Trisphosphate Receptors
2016
2 Citations (Scopus)

A novel approach to the expression and purification of recombinant Xenopus Cdc25C

Ramadan, S., Bendriss, G., Hubrack, S. Z., Al-Abdulmalek, A. & Machaca, K., 1 Apr 2016, In : Protein Expression and Purification. 120, p. 148-152 5 p.

Research output: Contribution to journalArticle

Xenopus
Trp-Ser- His-Pro-Gln-Phe-Glu-Lys
Meiosis
Oocytes
Dual-Specificity Phosphatases
4 Citations (Scopus)

Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells

Rahal, O. N., Fatfat, M., Hankache, C., Osman, B., Khalife, H., Machaca, K. & Muhtasib, H. G., 1 Nov 2016, In : Cancer Biology and Therapy. 17, 11, p. 1139-1148 10 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
DNA Damage
Reactive Oxygen Species
DNA
Cell Death
8 Citations (Scopus)

Release from Xenopus oocyte prophase I meiotic arrest is independent of a decrease in cAMP levels or PKA activity

Nader, N., Courjaret, R. J., Dib, M., Kulkarni, R. P. & Machaca, K., 1 Jun 2016, In : Development (Cambridge). 143, 11, p. 1926-1936 11 p.

Research output: Contribution to journalArticle

Meiotic Prophase I
Xenopus
Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Oocytes
4 Citations (Scopus)
Microvilli
Oocytes
Membranes
Epithelium
Oogenesis
2 Citations (Scopus)
Open Access
Xenopus
Oocytes
Cell Membrane
Physiological Phenomena
Muscle Development
2015
13 Citations (Scopus)
Cell Membrane
Endoplasmic Reticulum
Recycling
Proteins
5 Citations (Scopus)

The role of flexible loops in folding, trafficking and activity of equilibrative nucleoside transporters

Aseervatham, J., Tran, L., Machaca, K. & Boudker, O., 25 Sep 2015, In : PLoS One. 10, 9, e0136779.

Research output: Contribution to journalArticle

Nucleoside Transport Proteins
nucleosides
transporters
Nucleosides
Cell membranes
2014
36 Citations (Scopus)

Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

Fatfat, M., Merhi, R. A., Rahal, O., Stoyanovsky, D. A., Zaki, A., Haidar, H., Kagan, V. E., Gali-Muhtasib, H. & Machaca, K., 21 Jul 2014, In : BMC Cancer. 14, 1, 527.

Research output: Contribution to journalArticle

Colonic Neoplasms
Oxidation-Reduction
Copper
Reactive Oxygen Species
Metals
28 Citations (Scopus)
entry
effectors
lumens
Pumps
Inositol 1,4,5-Trisphosphate Receptors
4 Citations (Scopus)

Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest

Nader, N., Dib, M., Daalis, A., Kulkarni, R. P. & Machaca, K., 15 Nov 2014, In : Developmental Biology. 395, 2, p. 355-366 12 p.

Research output: Contribution to journalArticle

Endocytosis
Oocytes
Vertebrates
Meiosis
Progesterone
2013
16 Citations (Scopus)

Downregulation of store-operated Ca2+ entry during mammalian meiosis is required for the egg-to-embryo transition

Lee, B., Palermo, G. & Machaca, K., 1 Apr 2013, In : Journal of Cell Science. 126, 7, p. 1672-1681 10 p.

Research output: Contribution to journalArticle

Meiosis
Ovum
Down-Regulation
Embryonic Structures
Fertilization
19 Citations (Scopus)

How to make a good egg!. The need for remodeling of oocyte Ca2+ signaling to mediate the egg-to-embryo transition

Nader, N., Kulkarni, R. P., Dib, M. & Machaca, K., 2013, In : Cell Calcium. 53, 1, p. 41-54 14 p.

Research output: Contribution to journalArticle

Oocytes
Ovum
Embryonic Structures
Fertilization
Imagination
24 Citations (Scopus)

Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility

Abou-Saleh, H., Pathan, A. R., Daalis, A., Hubrack, S. Z., Abou-Jassoum, H., Al-Naeimi, H., Rusch, N. J. & Machaca, K., 15 Nov 2013, In : Journal of Biological Chemistry. 288, 46, p. 32941-32951 11 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Inositol 1,4,5-Trisphosphate
Vascular Smooth Muscle
Muscle
Up-Regulation
34 Citations (Scopus)

Intramolecular shielding maintains the ER Ca2+ sensor stim1 in an inactive conformation

Yu, F., Sun, L., Hubrack, S. Z., Selvaraj, S. & Machaca, K., 1 Jun 2013, In : Journal of Cell Science. 126, 11, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

Calcium
Physiological Phenomena
Cell Degranulation
Membranes
Stromal Interaction Molecule 1
17 Citations (Scopus)

Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffness

Chaston, D. J., Baillie, B. K., Grayson, T. H., Courjaret, R. J., Heisler, J. M., Lau, K. A., Machaca, K., Nicholson, B. J., Ashton, A., Matthaei, K. I. & Hill, C. E., May 2013, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 5, p. 962-970 9 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Pressure
Endothelium
Constriction
Transgenic Mice
11 Citations (Scopus)
Xenopus
Oocytes
Cations
Genes
Chemical activation
2012
5 Citations (Scopus)

Phosphorylation of the rat Ins(1,4,5)P3 receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P3

Haun, S., Sun, L., Hubrack, S. Z., Yule, D. & Machaca, K., 2012, In : Channels. 6, 5, p. 379-384 6 p.

Research output: Contribution to journalArticle

Phosphorylation
Rats
Meiosis
Allosteric Regulation
Physiology
24 Citations (Scopus)

STIM and Orai in cellular proliferation and division

Courjaret, R. J. & Machaca, K., 1 Jan 2012, In : Frontiers in Bioscience - Elite. 4 E, 1, p. 331-341 11 p.

Research output: Contribution to journalArticle

Cell Cycle
Cells
Cell Proliferation
Endoplasmic Reticulum
Organelles
2011
19 Citations (Scopus)

Endoplasmic reticulum remodeling tunes IP3-dependent Ca2+ release sensitivity

Sun, L., Yu, F., Ullah, A., Hubrack, S. Z., Daalis, A., Jung, P. & Machaca, K., 30 Nov 2011, In : PLoS One. 6, 11, e27928.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Endoplasmic Reticulum
endoplasmic reticulum
calcium
receptors
22 Citations (Scopus)

Role of the STIM1 C-terminal domain in STIM1 clustering

Yu, F., Sun, L., Courjaret, R. J. & Machaca, K., 11 Mar 2011, In : Journal of Biological Chemistry. 286, 10, p. 8375-8384 10 p.

Research output: Contribution to journalArticle

Meiosis
Cluster Analysis
Chemical activation
Xenopus
Endoplasmic Reticulum
2010
79 Citations (Scopus)

Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis

Yu, F., Sun, L. & Machaca, K., 1 Nov 2010, In : Journal of Cell Biology. 191, 3, p. 523-535 13 p.

Research output: Contribution to journalArticle

Caveolins
Meiosis
Recycling
Fertilization
Oocytes
19 Citations (Scopus)

Regulation of store-operated Ca2+ entry during the cell cycle

Arredouani, A., Yu, F., Sun, L. & Machaca, K., 1 Jul 2010, In : Journal of Cell Science. 123, 13, p. 2155-2162 8 p.

Research output: Contribution to journalArticle

Cell Division
Cell Cycle
Cell Physiological Phenomena
Interphase
Meiosis
2009
27 Citations (Scopus)

Kinase-dependent regulation of inositol 1,4,5-trisphosphate-dependent Ca2+ release during oocyte maturation

Sun, L., Haun, S., Jones, R. C., Edmondson, R. D. & Machaca, K., 24 Jul 2009, In : Journal of Biological Chemistry. 284, 30, p. 20184-20196 13 p.

Research output: Contribution to journalArticle

Maturation-Promoting Factor
Inositol 1,4,5-Trisphosphate Receptors
Inositol 1,4,5-Trisphosphate
Oocytes
Phosphotransferases
91 Citations (Scopus)
Meiosis
Cluster Analysis
Cell Membrane
Alanine
Cell Division
2008
19 Citations (Scopus)

Ca2+ homeostasis regulates Xenopus oocyte maturation

Sun, L., Hodeify, R., Haun, S., Charlesworth, A., MacNicol, A. M., Ponnappan, S., Ponnappan, U., Prigent, C. & Machaca, K., Apr 2008, In : Biology of Reproduction. 78, 4, p. 726-735 10 p.

Research output: Contribution to journalArticle

Aurora Kinase A
Xenopus
Oocytes
Meiosis
Homeostasis
22 Citations (Scopus)

Internalization of plasma membrane Ca2+-ATPase during Xenopus oocyte maturation

El-Jouni, W., Haun, S. & Machaca, K., 1 Dec 2008, In : Developmental Biology. 324, 1, p. 99-107 9 p.

Research output: Contribution to journalArticle

Plasma Membrane Calcium-Transporting ATPases
Calcium-Transporting ATPases
Xenopus
Oocytes
Cell Membrane
2007
33 Citations (Scopus)

Modeling Ca2+ signaling differentiation during oocyte maturation

Ullah, G., Jung, P. & Machaca, K., 2007, In : Cell Calcium. 42, 6, p. 556-564 9 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Fertilization
Oocytes
Plastics
Ovum
20 Citations (Scopus)

Vesicular traffic at the cell membrane regulates oocyte meiotic arrest

El-Jouni, W., Haun, S., Hodeify, R., Walker, A. H. & Machaca, K., Sep 2007, In : Development. 134, 18, p. 3307-3315 9 p.

Research output: Contribution to journalArticle

Oocytes
Cell Membrane
G-Protein-Coupled Receptors
Endocytosis
Cyclic AMP
19 Citations (Scopus)

Zinc regulates the ability of Cdc25C to activate MPF/cdk1

Sun, L., Chai, Y., Hannigan, R., Bhogaraju, V. K. & Machaca, K., Oct 2007, In : Journal of Cellular Physiology. 213, 1, p. 98-104 7 p.

Research output: Contribution to journalArticle

Zinc
Cell Cycle
Cells
Metalloproteins
Diamines
2005
45 Citations (Scopus)

Calcium signaling differentiation during Xenopus oocyte maturation

El-Jouni, W., Jang, B., Haun, S. & Machaca, K., 15 Dec 2005, In : Developmental Biology. 288, 2, p. 514-525 12 p.

Research output: Contribution to journalArticle

Calcium Signaling
Xenopus
Fertilization
Oocytes
Eggs
18 Citations (Scopus)

Rabphilin localizes with the cell actin cytoskeleton and stimulates association of granules with F-actin cross-linked by α-actinin

Baldini, G., Martelli, A. M., Tabellini, G., Horn, C., Machaca, K., Narducci, P. & Baldini, G., 14 Oct 2005, In : Journal of Biological Chemistry. 280, 41, p. 34974-34984 11 p.

Research output: Contribution to journalArticle

Actinin
Actin Cytoskeleton
Actins
Association reactions
Neuroendocrine Cells
229 Citations (Scopus)

RNA interference is an antiviral defence mechanism in Caenorhabditis elegans

Wilkins, C., Dishongh, R., Moore, S. C., Whitt, M. A., Chow, M. & Machaca, K., 18 Aug 2005, In : Nature. 436, 7053, p. 1044-1047 4 p.

Research output: Contribution to journalArticle

Caenorhabditis elegans
RNA Interference
Antiviral Agents
Vesicular Stomatitis
Virus Diseases
2004
40 Citations (Scopus)

Ca2+ cyt negatively regulates the initiation of oocyte maturation

Sun, L. & Machaca, K., 12 Apr 2004, In : Journal of Cell Biology. 165, 1, p. 63-75 13 p.

Research output: Contribution to journalArticle

Meiosis
Oocytes
Maturation-Promoting Factor
Cell Cycle
Phosphotransferases
41 Citations (Scopus)

Increased sensitivity and clustering of elementary Ca 2+ release events during oocyte maturation

Machaca, K., 1 Nov 2004, In : Developmental Biology. 275, 1, p. 170-182 13 p.

Research output: Contribution to journalArticle

Oocytes
Cluster Analysis
Eggs
Fertilization
Meiosis
2003
25 Citations (Scopus)

Ca2+-Calmodulin-dependent Protein Kinase II Potentiates Store-operated Ca2+ Current

Machaca, K., 5 Sep 2003, In : Journal of Biological Chemistry. 278, 36, p. 33730-33737 8 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Fertilization
Gene expression
Modulation
Gene Expression
2002
41 Citations (Scopus)

Endoplasmic reticulum Ca2+ signaling and calpains mediate renal cell death

Harriman, J. F., Liu, X. L., Aleo, M. D., Machaca, K. & Schnellmann, R. G., 2002, In : Cell Death and Differentiation. 9, 7, p. 734-741 8 p.

Research output: Contribution to journalArticle

Calpain
Antimycin A
Thapsigargin
Endoplasmic Reticulum
Cell Death
75 Citations (Scopus)
Maturation-Promoting Factor
Xenopus
Oocytes
Mitogen-Activated Protein Kinases
Ovum
2000
61 Citations (Scopus)

Store-operated calcium entry inactivates at the germinal vesicle breakdown stage of Xenopus meiosis

Machaca, K. & Haun, S., 8 Dec 2000, In : Journal of Biological Chemistry. 275, 49, p. 38710-38715 6 p.

Research output: Contribution to journalArticle

Meiosis
Xenopus
Calcium
Oocytes
Cell Cycle
1999
20 Citations (Scopus)
Inositol 1,4,5-Trisphosphate
Xenopus
Oocytes
Chemical activation
Ionomycin
33 Citations (Scopus)

Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents

Machaca, K. & Hartzell, H. C., 1999, In : Journal of General Physiology. 113, 2, p. 249-266 18 p.

Research output: Contribution to journalArticle

Cytosol
Cell Membrane
Coloring Agents
Endoplasmic Reticulum
Thapsigargin