• 3804 Citations
  • 35 h-Index
1993 …2020

Research output per year

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Research Output

  • 3804 Citations
  • 35 h-Index
  • 87 Article
  • 4 Review article
  • 2 Letter
  • 1 Chapter
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Article
2020

Flow-Cytometry Platform for Intracellular Detection of FVIII in Blood Cells: A New Tool to Assess Gene Therapy Efficiency for Hemophilia A

Elnaggar, M., Al-Mohannadi, A., Kizhakayil, D., Raynaud, C. M., Al-Mannai, S., Gentilcore, G., Pavlovski, I., Sathappan, A., Van Panhuys, N., Borsotti, C., Follenzi, A., Grivel, J. C. & Deola, S., 12 Jun 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
2019

Productive Cytomegalovirus Infection Is Associated With Impaired Endothelial Function in ST-Elevation Myocardial Infarction

Lebedeva, A., Maryukhnich, E., Grivel, J-C. B., Vasilieva, E., Margolis, L. & Shpektor, A., 1 Jan 2019, In : American Journal of Medicine.

Research output: Contribution to journalArticle

Open Access
2017

Analysis of RBC-microparticles in stored whole blood bags – a promising marker to detect blood doping in sports?

Voss, S. C., Jaganjac, M., Al-Thani, A. M., Grivel, J-C. B., Raynaud, C. M., Al-Jaber, H., Al-Menhali, A. S., Merenkov, Z. A., Alsayrafi, M., Latiff, A. & Georgakopoulos, C., 1 Nov 2017, In : Drug Testing and Analysis. 9, 11-12, p. 1794-1798 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Flow analysis of individual blood extracellular vesicles in acute coronary syndrome

Vagida, M., Arakelyan, A., Lebedeva, A., Grivel, J-C. B., Shpektor, A., Vasilieva, E. & Margolis, L., 17 Feb 2017, In : Platelets. 28, 2, p. 165-173 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Flow virometry analysis of envelope glycoprotein conformations on individual HIV virions

Arakelyan, A., Fitzgerald, W., King, D. F., Rogers, P., Cheeseman, H. M., Grivel, J-C. B., Shattock, R. J. & Margolis, L., 1 Dec 2017, In : Scientific Reports. 7, 1, 935.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Flow virometry to analyze antigenic spectra of virions and extracellular vesicles

Arakelyan, A., Fitzgerald, W., Zicari, S., Vagida, M., Grivel, J-C. B. & Margolis, L., 25 Jan 2017, In : Journal of Visualized Experiments. 2017, 119, e55020.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery

Tarca, A. L., Fitzgerald, W., Chaemsaithong, P., Xu, Z., Hassan, S. S., Grivel, J-C. B., Gomez-Lopez, N., Panaitescu, B., Pacora, P., Maymon, E., Erez, O., Margolis, L. & Romero, R., 1 Sep 2017, In : American Journal of Reproductive Immunology. 78, 3, e12686.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2016

Addition of thrombin reduces the recovery of extracellular vesicles from blood plasma

Arakelyan, A., Fitzgerald, W., Vagida, M., Vasilieva, E., Margolis, L. & Grivel, J-C. B., 4 Oct 2016, In : Journal of Circulating Biomarkers. 5

Research output: Contribution to journalArticle

Analysis of extracellular vesicles using magnetic nanoparticles in blood of patients with acute coronary syndrome

Vagida, M. S., Arakelyan, A., Lebedeva, A. M., Grivel, J-C. B., Shpektor, A. V., Vasilieva, E. Y. & Margolis, L. B., 1 Apr 2016, In : Biochemistry (Moscow). 81, 4, p. 382-391 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cytomegalovirus in plasma of acute coronary syndrome patients

Nikitskaya, E. A., Grivel, J-C. B., Maryukhnich, E. V., Lebedeva, A. M., Ivanova, O. I., Savvinova, P. P., Shpektor, A. V., Margolis, L. B. & Vasilieva, E. Y., 2016, In : Acta Naturae. 8, 2, p. 102-107 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Cytomegalovirus-Productive Infection Is Associated With Acute Coronary Syndrome

Nikitskaya, E., Lebedeva, A., Ivanova, O., Maryukhnich, E., Shpektor, A., Grivel, J-C. B., Margolis, L. & Vasilieva, E., 1 Aug 2016, In : Journal of the American Heart Association. 5, 8, e003759.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Evaluation of the maturation of individual Dengue virions with flow virometry

Zicari, S., Arakelyan, A., Fitzgerald, W., Zaitseva, E., Chernomordik, L. V., Margolis, L. & Grivel, J-C. B., 15 Jan 2016, In : Virology. 488, p. 20-27 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Modulation of immune responses by extracellular vesicles from retinal pigment epithelium

Knickelbein, J. E., Liu, B., Arakelyan, A., Zicari, S., Hannes, S., Chen, P., Li, Z., Grivel, J-C. B., Chaigne-Delalande, B., Sen, H. N., Margolis, L. & Nussenblatt, R. B., 1 Aug 2016, In : Investigative Ophthalmology and Visual Science. 57, 10, p. 4101-4107 7 p., 22.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Standardization of a cytometric p24-capture bead-assay for the detection of main HIV-subtypes

Merbah, M., Onkar, S., Grivel, J-C. B., Vanpouille, C., Biancotto, A., Bonar, L., Sanders-Buell, E., Kijak, G., Michael, N., Robb, M., Kim, J. H., Tovanabutra, S. & Chenine, A. L., 1 Apr 2016, In : Journal of Virological Methods. 230, p. 45-52 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Systemic inflammation and liver damage in HIV/hepatitis C virus coinfection

Shmagel, K. V., Saidakova, E. V., Shmagel, N. G., Korolevskaya, L. B., Chereshnev, V. A., Robinson, J., Grivel, J-C. B., Douek, D. C., Margolis, L., Anthony, D. D. & Lederman, M. M., 1 Sep 2016, In : HIV Medicine. 17, 8, p. 581-589 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2015

Antigenic composition of single nano-sized extracellular blood vesicles

Arakelyan, A., Ivanova, O., Vasilieva, E., Grivel, J-C. B. & Margolis, L., 2015, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 3, p. 489-498 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Evidence of perturbations of the cytokine network in preterm labor

Romero, R., Grivel, J-C. B., Tarca, A. L., Chaemsaithong, P., Xu, Z., Fitzgerald, W., Hassan, S. S., Chaiworapongsa, T. & Margolis, L., 2015, In : American Journal of Obstetrics and Gynecology. 213, 6, p. 836.e1-836.e18

Research output: Contribution to journalArticle

61 Citations (Scopus)

Valacyclovir decreases plasma HIV-1 RNA in HSV-2 seronegative individuals: A randomized placebo-controlled crossover trial

Vanpouille, C., Lisco, A., Grivel, J-C. B., Bassit, L. C., Kauffman, R. C., Sanchez, J., Schinazi, R. F., Lederman, M. M., Rodriguez, B. & Margolis, L., 1 Jun 2015, In : Clinical Infectious Diseases. 60, 11, p. 1708-1714 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2013

A universal nanoparticle cell secretion capture assay

Fitzgerald, W. & Grivel, J-C. B., Feb 2013, In : Cytometry Part A. 83 A, 2, p. 205-211 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Interleukin-7 Facilitates HIV-1 Transmission to Cervico-Vaginal Tissue ex vivo

Introini, A., Vanpouille, C., Lisco, A., Grivel, J-C. B. & Margolis, L., Feb 2013, In : PLoS Pathogens. 9, 2, e1003148.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Nanoparticle-based flow virometry for the analysis of individual virions

Arakelyan, A., Fitzgerald, W., Margolis, L. & Grivel, J-C. B., 3 Sep 2013, In : Journal of Clinical Investigation. 123, 9, p. 3716-3727 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle

Saba, E., Origoni, M., Taccagni, G., Ferrari, D., Doglioni, C., Nava, A., Lisco, A., Grivel, J-C. B., Margolis, L. & Poli, G., Nov 2013, In : Mucosal Immunology. 6, 6, p. 1081-1090 10 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
2012

Exploiting the anti-HIV-1 activity of acyclovir: Suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin

Vanpouille, C., Lisco, A., Introini, A., Grivel, J-C. B., Munawwar, A., Merbah, M., Schinazi, R. F., Derudas, M., McGuigan, C., Balzarini, J. & Margolis, L., May 2012, In : Antimicrobial Agents and Chemotherapy. 56, 5, p. 2604-2611 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

HIV-1 Expressing the Envelopes of Transmitted/Founder or Control/Reference Viruses Have Similar Infection Patterns of CD4 T-Cells in Human Cervical Tissue Ex Vivo

Merbah, M., Arakelyan, A., Edmonds, T., Ochsenbauer, C., Kappes, J. C., Shattock, R. J., Grivel, J-C. B. & Margolis, L. B., 6 Dec 2012, In : PLoS One. 7, 12, e50839.

Research output: Contribution to journalArticle

13 Citations (Scopus)

HIV-1 Imposes Rigidity on Blood and Semen Cytokine Networks

Lisco, A., Introini, A., Munawwar, A., Vanpouille, C., Grivel, J-C. B., Blank, P., Singh, S. & Margolis, L., Dec 2012, In : American Journal of Reproductive Immunology. 68, 6, p. 515-521 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Semen of HIV-1-infected individuals: Local shedding of herpesviruses and reprogrammed cytokine network

Lisco, A., Munawwar, A., Introini, A., Vanpouille, C., Saba, E., Feng, X., Grivel, J-C. B., Singh, S. & Margolis, L., 1 Jan 2012, In : Journal of Infectious Diseases. 205, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
2011

Activation of T lymphocytes in atherosclerotic plaques

Grivel, J-C. B., Ivanova, O., Pinegina, N., Blank, P. S., Shpektor, A., Margolis, L. B. & Vasilieva, E., Dec 2011, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 12, p. 2929-2937 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: A link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors

Almeida, M. Q., Tsang, K. M., Cheadle, C., Watkins, T., Grivel, J-C. B., Nesterova, M., Goldbach-Mansky, R. & Stratakis, C. A., Jan 2011, In : Human Molecular Genetics. 20, 1, p. 165-175 11 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2010

A new class of dual-targeted antivirals: Monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2

Vanpouille, C., Lisco, A., Derudas, M., Saba, E., Grivel, J-C. B., Brichacek, B., Scrimieri, F., Schinazi, R., Schols, D., McGuigan, C., Balzarini, J. & Margolis, L., 15 Feb 2010, In : Journal of Infectious Diseases. 201, 4, p. 635-643 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Contrasting roles for TLR ligands in HIV-1 pathogenesis

Brichacek, B., Vanpouille, C., Kiselyeva, Y., Biancotto, A., Merbah, M., Hirsch, I., Lisco, A., Grivel, J-C. B. & Margolis, L., 2010, In : PLoS One. 5, 9, p. 1-12 12 p., e12831.

Research output: Contribution to journalArticle

29 Citations (Scopus)

HIV-1 sexual transmission: Early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model

Saba, E., Grivel, J-C. B., Vanpouille, C., Brichacek, B., Fitzgerald, W., Margolis, L. & Lisco, A., May 2010, In : Mucosal Immunology. 3, 3, p. 280-290 11 p.

Research output: Contribution to journalArticle

97 Citations (Scopus)

Selective transmission of R5 HIV-1 variants: Where is the gatekeeper?

Grivel, J-C. B., Shattock, R. J. & Margolis, L. B., 27 Jan 2010, In : Journal of Translational Medicine. 9, SUPPL. 1, S6.

Research output: Contribution to journalArticle

87 Citations (Scopus)
2009

A highly sensitive and dynamic immunofluorescent cytometric bead assay for the detection of HIV-1 p24

Biancotto, A., Brichacek, B., Chen, S. S., Fitzgerald, W., Lisco, A., Vanpouille, C., Margolis, L. & Grivel, J-C. B., Apr 2009, In : Journal of Virological Methods. 157, 1, p. 98-101 4 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A

Biancotto, A., Grivel, J-C. B., Lisco, A., Vanpouille, C., Markham, P. D., Gallo, R. C., Margolis, L. B. & Lusso, P., 2 Jul 2009, In : Retrovirology. 6, 61.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Immune suppression of human lymphoid tissues and cells in rotating suspension culture and onboard the International Space Station

Fitzgerald, W., Chen, S., Walz, C., Zimmerberg, J., Margolis, L. & Grivel, J-C. B., Oct 2009, In : In Vitro Cellular and Developmental Biology - Animal. 45, 10, p. 622-632 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Multisite comparison of anti-human immunodeficiency virus microbicide activity in explant assays using a novel endpoint analysis

Richardson-Harman, N., Lackman-Smith, C., Fletcher, P. S., Anton, P. A., Bremer, J. W., Dezzutti, C. S., Elliott, J., Grivel, J-C. B., Guenthner, P., Gupta, P., Jones, M., Lurain, N. S., Margolis, L. B., Mohan, S., Ratner, D., Reichelderfer, P., Roberts, P., Shattock, R. J. & Cummins, J. E., Nov 2009, In : Journal of Clinical Microbiology. 47, 11, p. 3530-3539 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo

Sassi, A., Brichacek, B., Hieny, S., Yarovinsky, F., Golding, H., Grivel, J-C. B., Sher, A. & Margolis, L., Dec 2009, In : Microbes and Infection. 11, 14-15, p. 1106-1113 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Use of human tissue explants to study human infectious agents

Grivel, J-C. B. & Margolis, L., 2009, In : Nature Protocols. 4, 2, p. 256-269 14 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)
2008

Acyclovir Is Activated into a HIV-1 Reverse Transcriptase Inhibitor in Herpesvirus-Infected Human Tissues

Lisco, A., Vanpouille, C., Tchesnokov, E. P., Grivel, J-C. B., Biancotto, A., Brichacek, B., Elliott, J., Fromentin, E., Shattock, R., Anton, P., Gorelick, R., Balzarini, J., McGuigan, C., Derudas, M., Götte, M., Schinazi, R. F. & Margolis, L., 11 Sep 2008, In : Cell Host and Microbe. 4, 3, p. 260-270 11 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: A multicenter study

Fichorova, R. N., Richardson-Harman, N., Alfano, M., Belec, L., Carbonneil, C., Chen, S., Cosentino, L., Curtis, K., Dezzutti, C. S., Donoval, B., Doncel, G. F., Donaghay, M., Grivel, J-C. B., Guzman, E., Hayes, M., Herold, B., Hillier, S., Lackman-Smith, C., Landay, A., Margolis, L. & 11 others, Mayer, K. H., Pasicznyk, J. M., Pallansch-Cokonis, M., Poli, G., Reichelderfer, P., Roberts, P., Rodriguez, I., Saidi, H., Sassi, R. R., Shattock, R. & Cummins, J. E., 15 Jun 2008, In : Analytical Chemistry. 80, 12, p. 4741-4751 11 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

HIV-1-induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo

Biancotto, A., Iglehart, S. J., Vanpouille, C., Condack, C. E., Lisco, A., Ruecker, E., Hirsch, I., Margolis, L. B. & Grivel, J-C. B., 15 Jan 2008, In : Blood. 111, 2, p. 699-704 6 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo

Biancotto, A., Iglehart, S. J., Lisco, A., Vanpouille, C., Grivel, J-C. B., Lurain, N. S., Reichelderfer, P. S. & Margolis, L. B., 1 Mar 2008, In : AIDS Research and Human Retroviruses. 24, 3, p. 453-462 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2007

Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1

Biancotto, A., Grivel, J-C. B., Iglehart, S. J., Vanpouille, C., Lisco, A., Sieg, S. F., Debernardo, R., Garate, K., Rodriguez, B., Margolis, L. B. & Lederman, M. M., 15 May 2007, In : Blood. 109, 10, p. 4272-4279 8 p.

Research output: Contribution to journalArticle

157 Citations (Scopus)

Design and cellular kinetics of dansyl-labeled CADA derivatives with anti-HIV and CD4 receptor down-modulating activity

Vermeire, K., Lisco, A., Grivel, J-C. B., Scarbrough, E., Dey, K., Duffy, N., Margolis, L., Bell, T. W. & Schols, D., 15 Aug 2007, In : Biochemical Pharmacology. 74, 4, p. 566-578 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1

Grivel, J-C. B., Elliott, J., Lisco, A., Biancotto, A., Condack, C., Shattock, R. J., McGowan, I., Margolis, L. & Anton, P., Jun 2007, In : AIDS. 21, 10, p. 1263-1272 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Measles virus vaccine attenuation: Suboptimal infection of lymphatic tissue and tropism alteration

Condack, C., Grivel, J-C. B., Devaux, P., Margolis, L. & Cattaneo, R., 15 Aug 2007, In : Journal of Infectious Diseases. 196, 4, p. 541-549 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection

Münch, J., Rücker, E., Ständker, L., Adermann, K., Goffinet, C., Schindler, M., Wildum, S., Chinnadurai, R., Rajan, D., Specht, A., Giménez-Gallego, G., Sánchez, P. C., Fowler, D. M., Koulov, A., Kelly, J. W., Mothes, W., Grivel, J-C. B., Margolis, L., Keppler, O. T., Forssmann, W. G. & 1 others, Kirchhoff, F., 14 Dec 2007, In : Cell. 131, 6, p. 1059-1071 13 p.

Research output: Contribution to journalArticle

355 Citations (Scopus)

Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells

Van Laar, J. M., Melchers, M., Teng, Y. K. O., Van Der Zouwen, B., Mohammadi, R., Fischer, R., Margolis, L., Fitzgerald, W., Grivel, J-C. B., Breedveld, F. C., Lipsky, P. E. & Grammer, A. C., Sep 2007, In : American Journal of Pathology. 171, 3, p. 917-927 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation

Lisco, A., Grivel, J-C. B., Biancotto, A., Vanpouille, C., Origgi, F., Malnati, M. S., Schols, D., Lusso, P. & Margolis, L. B., Jan 2007, In : Journal of Virology. 81, 2, p. 708-717 10 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2006

Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides

Fletcher, P. S., Elliott, J., Grivel, J-C. B., Margolis, L., Anton, P., McGowan, I. & Shattock, R. J., Jun 2006, In : AIDS. 20, 9, p. 1237-1245 9 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)